Gene description for Jak2
Gene name	Janus kinase 2
Gene symbol	Jak2
Other names/aliases	Fd17
Species	Mus musculus
Database cross references - Jak2
ExoCarta	ExoCarta_16452
Vesiclepedia	VP_16452
Entrez Gene	16452
UniProt	Q62120
Jak2 identified in sEVs derived from the following tissue/cell type
Neural stem cells	25242146
Neural stem cells	25242146

Gene ontology annotations for Jak2

Molecular Function     protein tyrosine kinase activity GO:0004713 EXP     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 IMP     protein tyrosine kinase activity GO:0004713 ISO     protein tyrosine kinase activity GO:0004713 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS     signaling receptor binding GO:0005102 ISO     growth hormone receptor binding GO:0005131 IBA     growth hormone receptor binding GO:0005131 ISO     growth hormone receptor binding GO:0005131 ISS     interleukin-12 receptor binding GO:0005143 IPI     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     protein kinase binding GO:0019901 ISO     protein kinase binding GO:0019901 ISS     heme binding GO:0020037 ISO     heme binding GO:0020037 ISS     signaling receptor activator activity GO:0030546 IDA     type 1 angiotensin receptor binding GO:0031702 IEA     type 1 angiotensin receptor binding GO:0031702 ISO     acetylcholine receptor binding GO:0033130 IEA     acetylcholine receptor binding GO:0033130 ISO     histone H3Y41 kinase activity GO:0035401 ISO     histone H3Y41 kinase activity GO:0035401 ISS     SH2 domain binding GO:0042169 IEA     SH2 domain binding GO:0042169 ISO     histone binding GO:0042393 ISO     histone binding GO:0042393 ISS     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     phosphatidylinositol 3-kinase binding GO:0043548 IEA     phosphatidylinositol 3-kinase binding GO:0043548 ISO     insulin receptor substrate binding GO:0043560 IEA     insulin receptor substrate binding GO:0043560 ISO     metal ion binding GO:0046872 IEA     peptide hormone receptor binding GO:0051428 IEA     peptide hormone receptor binding GO:0051428 ISO     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     microglial cell activation GO:0001774 IGI     adaptive immune response GO:0002250 IEA     chromatin remodeling GO:0006338 IEA     transcription by RNA polymerase II GO:0006366 IGI     immune response GO:0006955 NAS     response to oxidative stress GO:0006979 ISO     response to oxidative stress GO:0006979 ISS     signal transduction GO:0007165 IMP     enzyme-linked receptor protein signaling pathway GO:0007167 IDA     G protein-coupled receptor signaling pathway GO:0007186 ISO     G protein-coupled receptor signaling pathway GO:0007186 ISS     positive regulation of cytosolic calcium ion concentration GO:0007204 ISO     positive regulation of cytosolic calcium ion concentration GO:0007204 ISS     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IBA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IGI     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP     cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISO     tyrosine phosphorylation of STAT protein GO:0007260 IDA     tyrosine phosphorylation of STAT protein GO:0007260 IMP     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISS     negative regulation of cell population proliferation GO:0008285 IMP     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISS     hormone-mediated signaling pathway GO:0009755 ISO     hormone-mediated signaling pathway GO:0009755 ISS     positive regulation of platelet activation GO:0010572 IEA     positive regulation of platelet activation GO:0010572 ISO     negative regulation of cardiac muscle cell apoptotic process GO:0010667 IEA     negative regulation of cardiac muscle cell apoptotic process GO:0010667 ISO     positive regulation of cell-substrate adhesion GO:0010811 ISO     positive regulation of cell-substrate adhesion GO:0010811 ISS     response to amine GO:0014075 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     cytokine-mediated signaling pathway GO:0019221 IBA     cytokine-mediated signaling pathway GO:0019221 IGI     cytokine-mediated signaling pathway GO:0019221 IMP     cytokine-mediated signaling pathway GO:0019221 ISO     cytokine-mediated signaling pathway GO:0019221 TAS     negative regulation of cell-cell adhesion GO:0022408 ISO     negative regulation of cell-cell adhesion GO:0022408 ISS     myeloid cell differentiation GO:0030099 IMP     cell differentiation GO:0030154 IMP     erythrocyte differentiation GO:0030218 IBA     erythrocyte differentiation GO:0030218 IMP     positive regulation of cell migration GO:0030335 ISO     positive regulation of cell migration GO:0030335 ISS     axon regeneration GO:0031103 ISO     axon regeneration GO:0031103 ISS     lipopolysaccharide-mediated signaling pathway GO:0031663 IMP     nuclear receptor-mediated mineralocorticoid signaling pathway GO:0031959 ISO     nuclear receptor-mediated mineralocorticoid signaling pathway GO:0031959 ISS     positive regulation of insulin secretion GO:0032024 ISO     positive regulation of insulin secretion GO:0032024 ISS     positive regulation of type II interferon production GO:0032729 ISO     positive regulation of interleukin-1 beta production GO:0032731 IGI     positive regulation of interleukin-1 beta production GO:0032731 ISO     positive regulation of interleukin-1 beta production GO:0032731 ISS     positive regulation of interleukin-17 production GO:0032740 NAS     positive regulation of tumor necrosis factor production GO:0032760 IDA     positive regulation of tumor necrosis factor production GO:0032760 IGI     positive regulation of natural killer cell proliferation GO:0032819 ISO     response to hydroperoxide GO:0033194 ISO     response to hydroperoxide GO:0033194 ISS     tumor necrosis factor-mediated signaling pathway GO:0033209 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 ISS     symbiont-induced defense-related programmed cell death GO:0034050 IDA     response to tumor necrosis factor GO:0034612 ISO     response to tumor necrosis factor GO:0034612 ISS     post-embryonic hemopoiesis GO:0035166 IMP     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 IDA     interleukin-12-mediated signaling pathway GO:0035722 ISO     interleukin-12-mediated signaling pathway GO:0035722 ISS     cellular response to interleukin-3 GO:0036016 IDA     interleukin-5-mediated signaling pathway GO:0038043 IEA     interleukin-5-mediated signaling pathway GO:0038043 ISO     collagen-activated signaling pathway GO:0038065 IEA     collagen-activated signaling pathway GO:0038065 ISO     interleukin-23-mediated signaling pathway GO:0038155 IEA     interleukin-3-mediated signaling pathway GO:0038156 IEA     interleukin-3-mediated signaling pathway GO:0038156 ISO     granulocyte-macrophage colony-stimulating factor signaling pathway GO:0038157 IEA     granulocyte-macrophage colony-stimulating factor signaling pathway GO:0038157 ISO     erythropoietin-mediated signaling pathway GO:0038162 IEA     positive regulation of T cell proliferation GO:0042102 IDA     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of protein import into nucleus GO:0042307 IEA     positive regulation of protein import into nucleus GO:0042307 ISO     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IDA     activation of Janus kinase activity GO:0042976 IDA     regulation of apoptotic process GO:0042981 IBA     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of apoptotic process GO:0043066 IDA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of DNA binding GO:0043392 IDA     positive regulation of MAPK cascade GO:0043410 IEA     positive regulation of MAPK cascade GO:0043410 ISO     negative regulation of neuron apoptotic process GO:0043524 IEA     negative regulation of neuron apoptotic process GO:0043524 ISO     post-translational protein modification GO:0043687 ISO     post-translational protein modification GO:0043687 ISS     positive regulation of MHC class II biosynthetic process GO:0045348 IGI     regulation of nitric oxide biosynthetic process GO:0045428 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISS     positive regulation of cell differentiation GO:0045597 ISO     positive regulation of cell differentiation GO:0045597 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 ISO     response to antibiotic GO:0046677 ISO     protein autophosphorylation GO:0046777 IDA     platelet-derived growth factor receptor signaling pathway GO:0048008 ISO     platelet-derived growth factor receptor signaling pathway GO:0048008 ISS     regulation of inflammatory response GO:0050727 ISO     regulation of inflammatory response GO:0050727 ISS     modulation of chemical synaptic transmission GO:0050804 IEA     modulation of chemical synaptic transmission GO:0050804 ISO     positive regulation of cell activation GO:0050867 ISO     positive regulation of cell activation GO:0050867 ISS     positive regulation of NK T cell proliferation GO:0051142 ISO     positive regulation of NK T cell proliferation GO:0051142 NAS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     type II interferon-mediated signaling pathway GO:0060333 ISO     type II interferon-mediated signaling pathway GO:0060333 ISS     positive regulation of SMAD protein signal transduction GO:0060391 ISO     growth hormone receptor signaling pathway GO:0060396 ISO     growth hormone receptor signaling pathway GO:0060396 ISS     growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IBA     growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IDA     growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IMP     growth hormone receptor signaling pathway via JAK-STAT GO:0060397 ISO     positive regulation of growth hormone receptor signaling pathway GO:0060399 IMP     mammary gland epithelium development GO:0061180 IMP     positive regulation of leukocyte proliferation GO:0070665 ISO     response to interleukin-12 GO:0070671 ISO     response to interleukin-12 GO:0070671 ISS     cellular response to lipopolysaccharide GO:0071222 IDA     cellular response to dexamethasone stimulus GO:0071549 IDA     response to granulocyte macrophage colony-stimulating factor GO:0097012 NAS     extrinsic apoptotic signaling pathway GO:0097191 IDA     positive regulation of cold-induced thermogenesis GO:0120162 IMP     defense response to symbiont GO:0140546 IMP     positive regulation of platelet aggregation GO:1901731 IEA     positive regulation of platelet aggregation GO:1901731 ISO     positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728 IEA     positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728 ISO     positive regulation of epithelial cell apoptotic process GO:1904037 IEA     positive regulation of epithelial cell apoptotic process GO:1904037 ISO     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IEA     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 ISO     regulation of postsynapse to nucleus signaling pathway GO:1905539 IEA     regulation of postsynapse to nucleus signaling pathway GO:1905539 ISO     positive regulation of T-helper 17 type immune response GO:2000318 NAS     positive regulation of apoptotic signaling pathway GO:2001235 IMP Subcellular Localization     euchromatin GO:0000791 IEA     euchromatin GO:0000791 ISO     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 TAS     cytosol GO:0005829 IBA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 NAS     caveola GO:0005901 IDA     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     endomembrane system GO:0012505 IEA     extrinsic component of plasma membrane GO:0019897 ISO     granulocyte macrophage colony-stimulating factor receptor complex GO:0030526 IEA     granulocyte macrophage colony-stimulating factor receptor complex GO:0030526 ISO     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IEA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISO     interleukin-12 receptor complex GO:0042022 NAS     membrane raft GO:0045121 IDA     interleukin-23 receptor complex GO:0072536 NAS     postsynapse GO:0098794 IEA     postsynapse GO:0098794 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO