Gene description for DSC2
Gene name desmocollin 2
Gene symbol DSC2
Other names/aliases ARVD11
CDHF2
DG2
DGII/III
DSC3
Species Homo sapiens
 Database cross references - DSC2
ExoCarta ExoCarta_1824
Vesiclepedia VP_1824
Entrez Gene 1824
HGNC 3036
MIM 125645
UniProt Q02487  
 DSC2 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for DSC2
Molecular Function
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
    cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 IC
Biological Process
    cell adhesion GO:0007155 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    cellular response to starvation GO:0009267 IEA
    cardiac muscle cell-cardiac muscle cell adhesion GO:0086042 IMP
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 IMP
    regulation of heart rate by cardiac conduction GO:0086091 IMP
    cell-cell adhesion GO:0098609 IBA
    regulation of ventricular cardiac muscle cell action potential GO:0098911 IMP
    positive regulation of p38MAPK cascade GO:1900745 IMP
Subcellular Localization
    cornified envelope GO:0001533 TAS
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 IEA
    intercalated disc GO:0014704 IDA
    desmosome GO:0030057 IBA
    desmosome GO:0030057 IDA
    cytoplasmic vesicle GO:0031410 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified DSC2 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
5
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DSC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 LCK 3932
Proximity Label-MS Homo sapiens
4 KLK15  
Affinity Capture-MS Homo sapiens
5 OCLN 100506658
Proximity Label-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 PKP2 5318
Two-hybrid Homo sapiens
9 CFC1  
Affinity Capture-MS Homo sapiens
10 HSD17B11 51170
Proximity Label-MS Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 SLURP1  
Affinity Capture-MS Homo sapiens
13 STX4 6810
Proximity Label-MS Homo sapiens
14 SOX2  
Affinity Capture-MS Homo sapiens
15 FNDC5  
Affinity Capture-MS Homo sapiens
16 PI4KA 5297
Affinity Capture-MS Homo sapiens
17 B3GAT1  
Proximity Label-MS Homo sapiens
18 MLLT4 4301
Proximity Label-MS Homo sapiens
19 SKA1  
Affinity Capture-MS Homo sapiens
20 BRWD3  
Affinity Capture-MS Homo sapiens
21 CLEC2B  
Affinity Capture-MS Homo sapiens
22 STX6 10228
Proximity Label-MS Homo sapiens
23 BRD4 23476
Affinity Capture-MS Homo sapiens
24 RAB35 11021
Proximity Label-MS Homo sapiens
25 BTNL2  
Affinity Capture-MS Homo sapiens
26 TMEM106A  
Affinity Capture-MS Homo sapiens
27 EBAG9 9166
Proximity Label-MS Homo sapiens
28 MARCKS 4082
Proximity Label-MS Homo sapiens
29 LAMTOR1 55004
Proximity Label-MS Homo sapiens
30 LMAN1 3998
Proximity Label-MS Homo sapiens
31 NUP155 9631
Proximity Label-MS Homo sapiens
32 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DSG1 1828
Affinity Capture-Western Homo sapiens
34 NRSN1  
Affinity Capture-MS Homo sapiens
35 EMD 2010
Proximity Label-MS Homo sapiens
36 CEACAM21  
Affinity Capture-MS Homo sapiens
37 ZDHHC19  
Affinity Capture-MS Homo sapiens
38 CXADR 1525
Proximity Label-MS Homo sapiens
39 CERS3  
Affinity Capture-MS Homo sapiens
40 LYN 4067
Proximity Label-MS Homo sapiens
41 TRIM24  
Affinity Capture-MS Homo sapiens
42 SRRT 51593
Affinity Capture-MS Homo sapiens
43 TNFSF13 8741
Affinity Capture-MS Homo sapiens
44 DNAJC5 80331
Proximity Label-MS Homo sapiens
45 SDF2L1 23753
Affinity Capture-MS Homo sapiens
46 DIRAS3  
Proximity Label-MS Homo sapiens
47 SSUH2  
Affinity Capture-MS Homo sapiens
48 RPN1 6184
Proximity Label-MS Homo sapiens
49 SEC61B 10952
Proximity Label-MS Homo sapiens
50 PSG11  
Affinity Capture-MS Homo sapiens
51 RPN2 6185
Proximity Label-MS Homo sapiens
52 RAB5A 5868
Proximity Label-MS Homo sapiens
53 PANX1 24145
Proximity Label-MS Homo sapiens
54 CMA1  
Affinity Capture-MS Homo sapiens
55 LILRA3  
Affinity Capture-MS Homo sapiens
56 EPB41L4A 64097
Proximity Label-MS Homo sapiens
57 LAMP1 3916
Proximity Label-MS Homo sapiens
58 BRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SLC35F2 54733
Affinity Capture-MS Homo sapiens
60 PRG2  
Affinity Capture-MS Homo sapiens
61 ARF6 382
Proximity Label-MS Homo sapiens
62 METTL21B  
Affinity Capture-MS Homo sapiens
63 IL5RA  
Affinity Capture-MS Homo sapiens
64 LYZL1  
Affinity Capture-MS Homo sapiens
65 PI4KAP1  
Affinity Capture-MS Homo sapiens
66 Flnb 286940
Affinity Capture-MS Mus musculus
67 ATP2A1 487
Proximity Label-MS Homo sapiens
68 FBXO2 26232
Affinity Capture-MS Homo sapiens
69 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
70 RAB9A 9367
Proximity Label-MS Homo sapiens
71 GXYLT1 283464
Affinity Capture-MS Homo sapiens
72 Jup 16480
Affinity Capture-MS Mus musculus
73 RHOB 388
Proximity Label-MS Homo sapiens
74 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 BRD3 8019
Affinity Capture-MS Homo sapiens
76 FLOT1 10211
Proximity Label-MS Homo sapiens
77 PKP3 11187
Two-hybrid Homo sapiens
78 DENND6A 201627
Proximity Label-MS Homo sapiens
79 ANKFY1 51479
Proximity Label-MS Homo sapiens
80 JUP 3728
Affinity Capture-Western Homo sapiens
81 RYK 6259
Affinity Capture-MS Homo sapiens
82 CD1A 909
Affinity Capture-MS Homo sapiens
83 NHLRC2 374354
Affinity Capture-MS Homo sapiens
84 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
85 C11orf52 91894
Proximity Label-MS Homo sapiens
86 EDDM3A  
Affinity Capture-MS Homo sapiens
87 MBNL1 4154
Affinity Capture-MS Homo sapiens
88 SIRPD  
Affinity Capture-MS Homo sapiens
89 RAB2A 5862
Proximity Label-MS Homo sapiens
90 SEC62 7095
Proximity Label-MS Homo sapiens
91 PINK1  
Affinity Capture-MS Homo sapiens
92 RAB11A 8766
Proximity Label-MS Homo sapiens
93 GOT1 2805
Affinity Capture-MS Homo sapiens
94 EPHA2 1969
Proximity Label-MS Homo sapiens
95 KIR2DL4  
Affinity Capture-MS Homo sapiens
96 KRAS 3845
Proximity Label-MS Homo sapiens
97 CAV1 857
Proximity Label-MS Homo sapiens
98 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
99 DSG2 1829
Reconstituted Complex Homo sapiens
100 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DSC2 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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