Gene description for DVL3
Gene name dishevelled segment polarity protein 3
Gene symbol DVL3
Other names/aliases -
Species Homo sapiens
 Database cross references - DVL3
ExoCarta ExoCarta_1857
Vesiclepedia VP_1857
Entrez Gene 1857
HGNC 3087
MIM 601368
UniProt Q92997  
 DVL3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DVL3
Molecular Function
    protease binding GO:0002020 IPI
    signaling receptor binding GO:0005102 IPI
    frizzled binding GO:0005109 IBA
    frizzled binding GO:0005109 IPI
    frizzled binding GO:0005109 TAS
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IDA
    small GTPase binding GO:0031267 IPI
Biological Process
    positive regulation of protein phosphorylation GO:0001934 IMP
    response to xenobiotic stimulus GO:0009410 IEA
    regulation of protein localization GO:0032880 IDA
    regulation of actin cytoskeleton organization GO:0032956 TAS
    intracellular signal transduction GO:0035556 IEA
    non-canonical Wnt signaling pathway GO:0035567 IMP
    non-canonical Wnt signaling pathway GO:0035567 ISS
    non-canonical Wnt signaling pathway GO:0035567 TAS
    positive regulation of GTPase activity GO:0043547 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of JNK cascade GO:0046330 IMP
    protein stabilization GO:0050821 IGI
    canonical Wnt signaling pathway GO:0060070 IBA
    canonical Wnt signaling pathway GO:0060070 IDA
    canonical Wnt signaling pathway GO:0060070 IGI
    canonical Wnt signaling pathway GO:0060070 IMP
    canonical Wnt signaling pathway GO:0060070 TAS
    Wnt signaling pathway, planar cell polarity pathway GO:0060071 IDA
    Wnt signaling pathway, planar cell polarity pathway GO:0060071 NAS
    positive regulation of neuron projection arborization GO:0150012 ISS
Subcellular Localization
    chromatin GO:0000785 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified DVL3 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DVL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZNF699  
Two-hybrid Homo sapiens
3 BAHD1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 ENKD1  
Two-hybrid Homo sapiens
5 PRR13  
Two-hybrid Homo sapiens
6 PRICKLE1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 AAK1 22848
Affinity Capture-MS Homo sapiens
8 WWP1 11059
Affinity Capture-Western Homo sapiens
9 LENG8  
Two-hybrid Homo sapiens
10 PPIE 10450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KCTD10 83892
Two-hybrid Homo sapiens
12 RBM15B  
Two-hybrid Homo sapiens
13 AES 166
Two-hybrid Homo sapiens
14 SQSTM1 8878
Proximity Label-MS Homo sapiens
15 PRPF38A 84950
Two-hybrid Homo sapiens
16 XPA  
Two-hybrid Homo sapiens
17 LUZP4  
Two-hybrid Homo sapiens
18 FAM13C  
Two-hybrid Homo sapiens
19 CSNK2A1 1457
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PRPF3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
21 DVL3 1857
FRET Homo sapiens
FRET Homo sapiens
22 AQR 9716
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SYF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SNIP1  
Two-hybrid Homo sapiens
25 UTP3 57050
Two-hybrid Homo sapiens
26 PCBP3 54039
Affinity Capture-MS Homo sapiens
27 TRIM54  
Two-hybrid Homo sapiens
28 MAB21L3  
Two-hybrid Homo sapiens
29 KAT7  
Two-hybrid Homo sapiens
30 CCNK  
Two-hybrid Homo sapiens
31 ZNF648  
Two-hybrid Homo sapiens
32 AKAP17A  
Two-hybrid Homo sapiens
33 RWDD2B  
Two-hybrid Homo sapiens
34 ZNF408  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
35 CEP70  
Two-hybrid Homo sapiens
36 CEP57L1  
Two-hybrid Homo sapiens
37 HOXA5  
Two-hybrid Homo sapiens
38 WT1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 ACTR3 10096
Proximity Label-MS Homo sapiens
40 ISY1 57461
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 WDR83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ZBTB47  
Two-hybrid Homo sapiens
43 MAGOHB 55110
Two-hybrid Homo sapiens
44 SUV39H1  
Two-hybrid Homo sapiens
45 ZNF512B  
Two-hybrid Homo sapiens
46 ZSCAN21  
Two-hybrid Homo sapiens
47 VAX1  
Two-hybrid Homo sapiens
48 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 TCEA2  
Two-hybrid Homo sapiens
50 NXN 64359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 KLF4  
Two-hybrid Homo sapiens
52 RRP8  
Two-hybrid Homo sapiens
53 TSPYL1 7259
Two-hybrid Homo sapiens
54 SYTL4 94121
Two-hybrid Homo sapiens
55 SNX27 81609
Affinity Capture-MS Homo sapiens
56 CSNK1D 1453
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
57 KLF15  
Two-hybrid Homo sapiens
58 TSN 7247
Two-hybrid Homo sapiens
59 PRKAA2 5563
Two-hybrid Homo sapiens
60 PRR20C  
Two-hybrid Homo sapiens
61 ZNF2  
Two-hybrid Homo sapiens
62 DVL2 1856
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 PRR20A  
Two-hybrid Homo sapiens
64 KCNE3  
Affinity Capture-MS Homo sapiens
65 PSME3 10197
Two-hybrid Homo sapiens
66 ADAP1  
Two-hybrid Homo sapiens
67 TRIM41 90933
Two-hybrid Homo sapiens
68 LONRF1  
Two-hybrid Homo sapiens
69 AP3M1 26985
Two-hybrid Homo sapiens
70 NKD1 85407
Two-hybrid Homo sapiens
71 ZNF444  
Two-hybrid Homo sapiens
72 HOXC5  
Two-hybrid Homo sapiens
73 PRR20E  
Two-hybrid Homo sapiens
74 FZD8 8325
Affinity Capture-Western Homo sapiens
75 RPS10 6204
Two-hybrid Homo sapiens
76 CCDC33 80125
Two-hybrid Homo sapiens
77 XAB2 56949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PPP1R16B  
Two-hybrid Homo sapiens
79 FGF16 8823
Two-hybrid Homo sapiens
80 ZBTB48  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 DPPA2  
Two-hybrid Homo sapiens
82 CDYL2  
Two-hybrid Homo sapiens
83 RASSF9  
Affinity Capture-MS Homo sapiens
84 CDH1 999
Proximity Label-MS Homo sapiens
85 PIK3CB 5291
Two-hybrid Homo sapiens
86 CYSRT1 375791
Two-hybrid Homo sapiens
87 NTRK1 4914
Affinity Capture-MS Homo sapiens
88 FOXK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 CCNL1  
Two-hybrid Homo sapiens
90 ZNF837  
Two-hybrid Homo sapiens
91 BEND7 222389
Two-hybrid Homo sapiens
92 CEP164  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 DDX54 79039
Two-hybrid Homo sapiens
94 CSNK1E 1454
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 PML 5371
Affinity Capture-MS Homo sapiens
96 STIL  
Proximity Label-MS Homo sapiens
97 ZNF581  
Two-hybrid Homo sapiens
98 ZRSR2  
Two-hybrid Homo sapiens
99 CEP76  
Two-hybrid Homo sapiens
100 AGPS 8540
Proximity Label-MS Homo sapiens
101 ITCH 83737
Affinity Capture-Western Homo sapiens
102 PRPF31 26121
Two-hybrid Homo sapiens
103 SNX22  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 CYLD  
Affinity Capture-Western Homo sapiens
105 RPL11 6135
Two-hybrid Homo sapiens
106 ZNF774  
Two-hybrid Homo sapiens
107 LOC400927-CSNK1E  
Two-hybrid Homo sapiens
108 ZNF775  
Two-hybrid Homo sapiens
109 PHLPP1  
Proximity Label-MS Homo sapiens
110 NUMA1 4926
Affinity Capture-Western Homo sapiens
111 PLN  
Two-hybrid Homo sapiens
112 ZNF821  
Two-hybrid Homo sapiens
113 RBM39 9584
Two-hybrid Homo sapiens
114 TNFAIP8L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
115 ABT1 29777
Two-hybrid Homo sapiens
116 CEP135  
Proximity Label-MS Homo sapiens
117 ATL3 25923
Affinity Capture-MS Homo sapiens
118 XPO1 7514
Affinity Capture-MS Homo sapiens
119 SAP30L  
Two-hybrid Homo sapiens
120 ZBTB24  
Two-hybrid Homo sapiens
121 EPB41L4A 64097
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 CTNNB1 1499
Affinity Capture-Western Homo sapiens
123 MAGEB4  
Two-hybrid Homo sapiens
124 WDR25  
Two-hybrid Homo sapiens
125 C19orf66  
Two-hybrid Homo sapiens
126 ZNF71  
Two-hybrid Homo sapiens
127 KLF1  
Two-hybrid Homo sapiens
128 SYT6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
129 PRR20D  
Two-hybrid Homo sapiens
130 BHLHE40  
Two-hybrid Homo sapiens
131 GADD45GIP1  
Two-hybrid Homo sapiens
132 FAM90A1  
Two-hybrid Homo sapiens
133 ANKRD36B  
Two-hybrid Homo sapiens
134 C8orf33 65265
Two-hybrid Homo sapiens
135 KAZN  
Two-hybrid Homo sapiens
136 TNP1  
Two-hybrid Homo sapiens
137 NXF1 10482
Two-hybrid Homo sapiens
138 NXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 STOM 2040
Two-hybrid Homo sapiens
140 YTHDC1  
Two-hybrid Homo sapiens
141 UBE2D2 7322
Affinity Capture-MS Homo sapiens
142 PRR20B  
Two-hybrid Homo sapiens
143 Smurf2  
Affinity Capture-Luminescence Mus musculus
144 PCBP1 5093
Affinity Capture-MS Homo sapiens
145 RPA3 6119
Proximity Label-MS Homo sapiens
146 RASSF10  
Affinity Capture-MS Homo sapiens
147 TCEANC  
Two-hybrid Homo sapiens
148 INO80B 83444
Two-hybrid Homo sapiens
149 NOL12 79159
Two-hybrid Homo sapiens
150 GOLGA1  
Proximity Label-MS Homo sapiens
151 RPA4  
Proximity Label-MS Homo sapiens
152 SORBS3 10174
Two-hybrid Homo sapiens
153 DIDO1  
Two-hybrid Homo sapiens
154 CCDC88A 55704
Affinity Capture-MS Homo sapiens
155 CT45A10  
Two-hybrid Homo sapiens
156 ZNF696  
Two-hybrid Homo sapiens
157 FOXK1 221937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 ZNF417  
Two-hybrid Homo sapiens
159 PRPF18  
Two-hybrid Homo sapiens
160 ZNF165  
Two-hybrid Homo sapiens
161 HUWE1 10075
Affinity Capture-Western Homo sapiens
162 ZNF319  
Two-hybrid Homo sapiens
163 SEC24B 10427
Affinity Capture-MS Homo sapiens
164 RNF43  
Proximity Label-MS Homo sapiens
165 TFG 10342
Two-hybrid Homo sapiens
166 DVL1 1855
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
167 ANKFY1 51479
Proximity Label-MS Homo sapiens
168 RNF151  
Two-hybrid Homo sapiens
169 TRAF2 7186
Two-hybrid Homo sapiens
170 DAB2 1601
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
171 PLEC 5339
Affinity Capture-MS Homo sapiens
172 ZNF441  
Two-hybrid Homo sapiens
173 PLAGL2  
Two-hybrid Homo sapiens
174 ZNF264  
Two-hybrid Homo sapiens
175 TSPYL6  
Two-hybrid Homo sapiens
176 WWOX 51741
Affinity Capture-MS Homo sapiens
177 ZBTB8A  
Two-hybrid Homo sapiens
178 CT45A3 441519
Two-hybrid Homo sapiens
179 KLF3  
Two-hybrid Homo sapiens
180 KCTD7 154881
Two-hybrid Homo sapiens
181 KLHL12  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
182 ZBTB26  
Two-hybrid Homo sapiens
183 PITX1  
Two-hybrid Homo sapiens
184 SEPT10 151011
Proximity Label-MS Homo sapiens
185 C1orf35  
Two-hybrid Homo sapiens
186 PHF19  
Two-hybrid Homo sapiens
187 EIF1B  
Two-hybrid Homo sapiens
188 VANGL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 ZNF764 92595
Two-hybrid Homo sapiens
190 AXIN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
191 ZNF792 126375
Two-hybrid Homo sapiens
192 THAP7  
Two-hybrid Homo sapiens
193 ZNF497  
Two-hybrid Homo sapiens
194 KDM1A 23028
Proximity Label-MS Homo sapiens
195 ZNF552  
Two-hybrid Homo sapiens
196 ZSCAN22  
Two-hybrid Homo sapiens
197 EYA4 2070
Affinity Capture-MS Homo sapiens
198 LRRK2 120892
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
199 WWTR1 25937
Affinity Capture-Western Homo sapiens
200 FARS2 10667
Two-hybrid Homo sapiens
201 CBX8 57332
Two-hybrid Homo sapiens
202 PSMF1 9491
Two-hybrid Homo sapiens
203 ZNF697  
Two-hybrid Homo sapiens
204 XRCC6 2547
Proximity Label-MS Homo sapiens
205 Axin1  
Two-hybrid Rattus norvegicus
206 SNW1 22938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 CRNKL1 51340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 VANGL1 81839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 MATN2 4147
Two-hybrid Homo sapiens
210 ALS2CR12  
Two-hybrid Homo sapiens
211 ZFP57  
Two-hybrid Homo sapiens
212 LNX1  
Two-hybrid Homo sapiens
213 ZSCAN25  
Two-hybrid Homo sapiens
214 CDC5L 988
Affinity Capture-MS Homo sapiens
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