Gene description for S100a6
Gene name S100 calcium binding protein A6 (calcyclin)
Gene symbol S100a6
Other names/aliases 2A9
5B10
CALCYCLIN
Cacy
PRA
Species Mus musculus
 Database cross references - S100a6
ExoCarta ExoCarta_20200
Vesiclepedia VP_20200
Entrez Gene 20200
UniProt P14069  
 S100a6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for S100a6
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    tropomyosin binding GO:0005523 IEA
    tropomyosin binding GO:0005523 ISO
    zinc ion binding GO:0008270 IDA
    monoatomic ion transmembrane transporter activity GO:0015075 IEA
    monoatomic ion transmembrane transporter activity GO:0015075 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    S100 protein binding GO:0044548 IBA
    S100 protein binding GO:0044548 IEA
    S100 protein binding GO:0044548 ISO
    calcium-dependent protein binding GO:0048306 IBA
    calcium-dependent protein binding GO:0048306 IEA
    calcium-dependent protein binding GO:0048306 ISO
Biological Process
    monoatomic ion transmembrane transport GO:0034220 IEA
Subcellular Localization
    ruffle GO:0001726 IEA
    ruffle GO:0001726 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nuclear envelope GO:0005635 IEA
    nuclear envelope GO:0005635 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISS
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified S100a6 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for S100a6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 S100b  
Co-fractionation Mus musculus
2 Cacybp 12301
Affinity Capture-Western Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Anxa2 12306
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which S100a6 is involved
No pathways found





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