Gene description for Ugp2
Gene name UDP-glucose pyrophosphorylase 2
Gene symbol Ugp2
Other names/aliases UDPGP
UGPase
Species Mus musculus
 Database cross references - Ugp2
ExoCarta ExoCarta_216558
Vesiclepedia VP_216558
Entrez Gene 216558
UniProt Q91ZJ5  
 Ugp2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ugp2
Molecular Function
    UTP:glucose-1-phosphate uridylyltransferase activity GO:0003983 IBA
    UTP:glucose-1-phosphate uridylyltransferase activity GO:0003983 IMP
    UTP:glucose-1-phosphate uridylyltransferase activity GO:0003983 ISO
    D-glucose binding GO:0005536 IEA
    D-glucose binding GO:0005536 ISO
    pyrimidine ribonucleotide binding GO:0032557 IEA
    pyrimidine ribonucleotide binding GO:0032557 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
    UTP-monosaccharide-1-phosphate uridylyltransferase activity GO:0051748 IMP
Biological Process
    glycogen metabolic process GO:0005977 IBA
    glycogen biosynthetic process GO:0005978 IEA
    glycogen biosynthetic process GO:0005978 IMP
    glycogen biosynthetic process GO:0005978 ISO
    UDP-alpha-D-glucose metabolic process GO:0006011 IBA
    UDP-alpha-D-glucose metabolic process GO:0006011 IEA
    UDP-alpha-D-glucose metabolic process GO:0006011 ISO
    UDP-glucuronate biosynthetic process GO:0006065 IMP
    brain development GO:0007420 IEA
    brain development GO:0007420 ISO
    glucose 1-phosphate metabolic process GO:0019255 IEA
    glucose 1-phosphate metabolic process GO:0019255 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ugp2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ugp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zyx  
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Ranbp3  
Co-fractionation Mus musculus
4 Ppp2r5c 26931
Co-fractionation Mus musculus
5 Puf60 67959
Co-fractionation Mus musculus
6 Unk  
Affinity Capture-RNA Mus musculus
7 Ugp2 216558
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
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