Gene description for BCL2L13
Gene name BCL2-like 13 (apoptosis facilitator)
Gene symbol BCL2L13
Other names/aliases BCL-RAMBO
Bcl2-L-13
MIL1
Species Homo sapiens
 Database cross references - BCL2L13
ExoCarta ExoCarta_23786
Vesiclepedia VP_23786
Entrez Gene 23786
HGNC 17164
UniProt Q9BXK5  
 BCL2L13 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BCL2L13
Molecular Function
    protein binding GO:0005515 IPI
    cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 NAS
Biological Process
    mitophagy GO:0000423 IEA
    oxidative phosphorylation GO:0006119 IEA
    apoptotic process GO:0006915 NAS
    mitochondrion organization GO:0007005 IEA
    regulation of apoptotic process GO:0042981 IEA
    fat cell differentiation GO:0045444 IEA
    canonical glycolysis GO:0061621 IEA
    positive regulation of cysteine-type endopeptidase activity GO:2001056 NAS
Subcellular Localization
    nucleus GO:0005634 IEA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 NAS
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified BCL2L13 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 236
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BCL2L13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOMM40 10452
Co-fractionation Homo sapiens
2 BET1 10282
Two-hybrid Homo sapiens
3 NINJ2  
Two-hybrid Homo sapiens
4 POR 5447
Co-fractionation Homo sapiens
5 COX2 4513
Co-fractionation Homo sapiens
6 UPK1B 7348
Two-hybrid Homo sapiens
7 TSPAN31 6302
Affinity Capture-MS Homo sapiens
8 SOD1 6647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 AIFM1 9131
Proximity Label-MS Homo sapiens
10 CANX 821
Co-fractionation Homo sapiens
11 PNPT1 87178
Co-fractionation Homo sapiens
12 GABARAPL2 11345
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 MTNR1B  
Two-hybrid Homo sapiens
14 BSG 682
Co-fractionation Homo sapiens
15 RAB5A 5868
Proximity Label-MS Homo sapiens
16 NPTN 27020
Co-fractionation Homo sapiens
17 DLD 1738
Co-fractionation Homo sapiens
18 MTCH2 23788
Proximity Label-MS Homo sapiens
19 MCFD2 90411
Co-fractionation Homo sapiens
20 VAMP4 8674
Two-hybrid Homo sapiens
21 VAMP3 9341
Two-hybrid Homo sapiens
22 TMEM86B  
Two-hybrid Homo sapiens
23 FKBP8 23770
Proximity Label-MS Homo sapiens
24 PLN  
Two-hybrid Homo sapiens
25 RHOT2 89941
Proximity Label-MS Homo sapiens
26 SCO1  
Co-fractionation Homo sapiens
27 APP 351
Reconstituted Complex Homo sapiens
28 PLLP  
Two-hybrid Homo sapiens
29 OCIAD1 54940
Proximity Label-MS Homo sapiens
30 KIAA1429 25962
Affinity Capture-MS Homo sapiens
31 TMUB2  
Two-hybrid Homo sapiens
32 CHCHD4  
Co-fractionation Homo sapiens
33 FIS1 51024
Proximity Label-MS Homo sapiens
34 RAB7A 7879
Proximity Label-MS Homo sapiens
35 EFNA4  
Affinity Capture-MS Homo sapiens
36 CYB5R3 1727
Co-fractionation Homo sapiens
37 MTCH1 23787
Proximity Label-MS Homo sapiens
38 SORBS3 10174
Affinity Capture-MS Homo sapiens
39 COX7C 1350
Co-fractionation Homo sapiens
40 CD44 960
Co-fractionation Homo sapiens
41 TMEM128  
Two-hybrid Homo sapiens
42 ITGB5 3693
Co-fractionation Homo sapiens
43 MARCH5  
Proximity Label-MS Homo sapiens
44 SND1 27044
Co-fractionation Homo sapiens
45 AKAP1 8165
Proximity Label-MS Homo sapiens
46 MAVS 57506
Proximity Label-MS Homo sapiens
47 EXD2  
Proximity Label-MS Homo sapiens
48 VDAC3 7419
Co-fractionation Homo sapiens
49 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SLC25A46 91137
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BCL2L13 is involved
No pathways found





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