Gene description for UPK1B
Gene name uroplakin 1B
Gene symbol UPK1B
Other names/aliases TSPAN20
UPIB
UPK1
Species Homo sapiens
 Database cross references - UPK1B
ExoCarta ExoCarta_7348
Vesiclepedia VP_7348
Entrez Gene 7348
HGNC 12578
MIM 602380
UniProt O75841  
 UPK1B identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for UPK1B
Molecular Function
    structural molecule activity GO:0005198 NAS
    protein binding GO:0005515 IPI
Biological Process
    response to bacterium GO:0009617 IEA
    epithelial cell differentiation GO:0030855 IDA
Subcellular Localization
    membrane GO:0016020 NAS
    extracellular exosome GO:0070062 HDA
    apical plasma membrane urothelial plaque GO:0120001 IEA
 Experiment description of studies that identified UPK1B in sEVs
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for UPK1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM91  
Two-hybrid Homo sapiens
2 GJA8  
Two-hybrid Homo sapiens
3 KIR2DL3  
Two-hybrid Homo sapiens
4 GPX8 493869
Two-hybrid Homo sapiens
5 SYT9 143425
Two-hybrid Homo sapiens
6 FNDC9  
Two-hybrid Homo sapiens
7 SHISA4 149345
Two-hybrid Homo sapiens
8 SSMEM1  
Two-hybrid Homo sapiens
9 C6orf57  
Two-hybrid Homo sapiens
10 CD69  
Two-hybrid Homo sapiens
11 FFAR2  
Two-hybrid Homo sapiens
12 SLC16A2  
Two-hybrid Homo sapiens
13 GPR161  
Two-hybrid Homo sapiens
14 MS4A4A  
Two-hybrid Homo sapiens
15 VSIG1  
Two-hybrid Homo sapiens
16 ITGB2 3689
Two-hybrid Homo sapiens
17 TMEM54  
Two-hybrid Homo sapiens
18 SPINT1 6692
Two-hybrid Homo sapiens
19 CLDN7 1366
Two-hybrid Homo sapiens
20 PPAPDC1A  
Two-hybrid Homo sapiens
21 TMUB2  
Two-hybrid Homo sapiens
22 TMEM139  
Two-hybrid Homo sapiens
23 SLC10A2  
Two-hybrid Homo sapiens
24 TMEM194A  
Two-hybrid Homo sapiens
25 FAM209A 200232
Two-hybrid Homo sapiens
26 CCDC155  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 SLC39A2  
Two-hybrid Homo sapiens
28 CD53 963
Two-hybrid Homo sapiens
29 BCL2L13 23786
Two-hybrid Homo sapiens
30 STX1A 6804
Two-hybrid Homo sapiens
31 TMEM262  
Two-hybrid Homo sapiens
32 GJB1 2705
Two-hybrid Homo sapiens
33 GPR37L1  
Two-hybrid Homo sapiens
34 RHCG 51458
Two-hybrid Homo sapiens
35 BNIP2  
Two-hybrid Homo sapiens
36 KCNJ6  
Two-hybrid Homo sapiens
37 TMEM45B 120224
Two-hybrid Homo sapiens
38 PDZK1IP1 10158
Two-hybrid Homo sapiens
39 SIT1 27240
Two-hybrid Homo sapiens
40 ISLR2  
Two-hybrid Homo sapiens
41 KLRC1  
Two-hybrid Homo sapiens
42 TMEM237 65062
Two-hybrid Homo sapiens
43 UPK3A 7380
Affinity Capture-Western Homo sapiens
44 MFF 56947
Two-hybrid Homo sapiens
45 DAGLA 747
Two-hybrid Homo sapiens
46 EDAR  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UPK1B is involved
No pathways found





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