Gene description for TMEM45B
Gene name transmembrane protein 45B
Gene symbol TMEM45B
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM45B
ExoCarta ExoCarta_120224
Vesiclepedia VP_120224
Entrez Gene 120224
HGNC 25194
UniProt Q96B21  
 TMEM45B identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 25890246    
 Gene ontology annotations for TMEM45B
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    innate immune response GO:0045087 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 IEA
    Golgi apparatus GO:0005794 IEA
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified TMEM45B in sEVs
1
Experiment ID 286
MISEV standards
CEM
Biophysical techniques
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
Negative markers
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TMEM45B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM60  
Two-hybrid Homo sapiens
2 SMAGP  
Two-hybrid Homo sapiens
3 CDS2 8760
Two-hybrid Homo sapiens
4 METTL18  
Affinity Capture-MS Homo sapiens
5 SEC23A 10484
Two-hybrid Homo sapiens
6 LAT 27040
Two-hybrid Homo sapiens
7 UPK1B 7348
Two-hybrid Homo sapiens
8 BMP10  
Two-hybrid Homo sapiens
9 PLP1 5354
Two-hybrid Homo sapiens
10 TMEM218  
Two-hybrid Homo sapiens
11 TMEM254  
Two-hybrid Homo sapiens
12 INSIG2  
Two-hybrid Homo sapiens
13 EPN1 29924
Affinity Capture-MS Homo sapiens
14 SMIM1 388588
Two-hybrid Homo sapiens
15 AQP1 358
Two-hybrid Homo sapiens
16 TREX1  
Two-hybrid Homo sapiens
17 FAM3C 10447
Two-hybrid Homo sapiens
18 TMEM128  
Two-hybrid Homo sapiens
19 CYB561D2 11068
Two-hybrid Homo sapiens
20 TSPAN33 340348
Two-hybrid Homo sapiens
21 FKBP8 23770
Two-hybrid Homo sapiens
22 NSG1  
Two-hybrid Homo sapiens
23 PLN  
Two-hybrid Homo sapiens
24 SMAP2 64744
Affinity Capture-MS Homo sapiens
25 TINAG  
Two-hybrid Homo sapiens
26 APOD 347
Two-hybrid Homo sapiens
27 UBE2G2  
Two-hybrid Homo sapiens
28 TMEM229B  
Two-hybrid Homo sapiens
29 APOL2 23780
Two-hybrid Homo sapiens
30 TMEM243  
Two-hybrid Homo sapiens
31 SEC22A  
Two-hybrid Homo sapiens
32 DOLK 22845
Two-hybrid Homo sapiens
33 PPAPDC1A  
Two-hybrid Homo sapiens
34 C4orf3  
Two-hybrid Homo sapiens
35 GIMAP1  
Two-hybrid Homo sapiens
36 C2orf82  
Two-hybrid Homo sapiens
37 VAMP5 10791
Two-hybrid Homo sapiens
38 VKORC1 79001
Two-hybrid Homo sapiens
39 TNFRSF10C  
Two-hybrid Homo sapiens
40 CACNG1  
Two-hybrid Homo sapiens
41 ANKRD46 157567
Two-hybrid Homo sapiens
42 ERP27  
Affinity Capture-MS Homo sapiens
43 C3orf52  
Two-hybrid Homo sapiens
44 TMEM97 27346
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM45B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here