Gene description for GPX7
Gene name glutathione peroxidase 7
Gene symbol GPX7
Other names/aliases CL683
GPX6
GPx-7
GSHPx-7
NPGPx
Species Homo sapiens
 Database cross references - GPX7
ExoCarta ExoCarta_2882
Vesiclepedia VP_2882
Entrez Gene 2882
HGNC 4559
MIM 615784
UniProt Q96SL4  
 GPX7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GPX7
Molecular Function
    catalase activity GO:0004096 IDA
    peroxidase activity GO:0004601 EXP
    peroxidase activity GO:0004601 IBA
    glutathione peroxidase activity GO:0004602 IEA
    protein binding GO:0005515 IPI
Biological Process
    cellular response to oxidative stress GO:0034599 TAS
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified GPX7 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GPX7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX1 6642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 DNPEP 23549
Affinity Capture-MS Homo sapiens
3 C9orf142  
Affinity Capture-MS Homo sapiens
4 HSPA5 3309
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 HS3ST1  
Affinity Capture-MS Homo sapiens
6 UBQLN4 56893
Two-hybrid Homo sapiens
7 PARP1 142
Proximity Label-MS Homo sapiens
8 HPCAL4  
Affinity Capture-MS Homo sapiens
9 EEF1A1 1915
Affinity Capture-MS Homo sapiens
10 SEC23IP 11196
Affinity Capture-MS Homo sapiens
11 HSPA14 51182
Affinity Capture-MS Homo sapiens
12 CPNE7 27132
Two-hybrid Homo sapiens
13 PDIA4 9601
Affinity Capture-MS Homo sapiens
14 NCALD 83988
Two-hybrid Homo sapiens
15 UBQLN2 29978
Two-hybrid Homo sapiens
16 EIF2AK2 5610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GMPS 8833
Affinity Capture-MS Homo sapiens
18 GAK 2580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CHMP1A 5119
Affinity Capture-MS Homo sapiens
20 HSPA13 6782
Affinity Capture-MS Homo sapiens
21 NFS1 9054
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 THYN1 29087
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ERO1L 30001
PCA Homo sapiens
24 C1orf52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SGTB  
Two-hybrid Homo sapiens
26 PLEKHJ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ZC3HC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FAM109A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PCDH1 5097
Affinity Capture-MS Homo sapiens
30 RIPK1 8737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 FARSB 10056
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 OR2L13  
Affinity Capture-MS Homo sapiens
33 RANBP3 8498
Affinity Capture-MS Homo sapiens
34 SH3GL1 6455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PTPN11 5781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ASNA1 439
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
38 PSME1 5720
Affinity Capture-MS Homo sapiens
39 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
40 CEP70  
Two-hybrid Homo sapiens
41 WDYHV1  
Two-hybrid Homo sapiens
42 FTO 79068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PAPSS1 9061
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ZG16B 124220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 THNSL1 79896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ASPH 444
Two-hybrid Homo sapiens
47 PYCRL 65263
Affinity Capture-MS Homo sapiens
48 NMU  
Affinity Capture-MS Homo sapiens
49 P4HB 5034
Affinity Capture-Western Homo sapiens
50 ZC3HAV1L 92092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 LYRM4 57128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 UTP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 HSPA9 3313
Affinity Capture-MS Homo sapiens
55 MCTS1 28985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 BMP4 652
Affinity Capture-MS Homo sapiens
57 TNFSF9  
Affinity Capture-MS Homo sapiens
58 DNAJB11 51726
Affinity Capture-MS Homo sapiens
59 CHORDC1 26973
Affinity Capture-MS Homo sapiens
60 OCRL 4952
Affinity Capture-MS Homo sapiens
61 TCF25 22980
Two-hybrid Homo sapiens
62 PROSC 11212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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