Gene description for TMOD2
Gene name tropomodulin 2 (neuronal)
Gene symbol TMOD2
Other names/aliases N-TMOD
NTMOD
Species Homo sapiens
 Database cross references - TMOD2
ExoCarta ExoCarta_29767
Vesiclepedia VP_29767
Entrez Gene 29767
HGNC 11872
MIM 602928
UniProt Q9NZR1  
 TMOD2 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
 Gene ontology annotations for TMOD2
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    tropomyosin binding GO:0005523 IBA
Biological Process
    muscle contraction GO:0006936 IBA
    actin filament organization GO:0007015 IBA
    neuron-neuron synaptic transmission GO:0007270 IEA
    nervous system development GO:0007399 TAS
    learning or memory GO:0007611 IEA
    myofibril assembly GO:0030239 IBA
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IEA
    pointed-end actin filament capping GO:0051694 IEA
Subcellular Localization
    cytoskeleton GO:0005856 IBA
    striated muscle thin filament GO:0005865 IBA
    myofibril GO:0030016 IBA
    synapse GO:0045202 IEA
 Experiment description of studies that identified TMOD2 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for TMOD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PLEKHG6  
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 LUZP4  
Affinity Capture-MS Homo sapiens
5 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
6 SF3B2 10992
Co-fractionation Homo sapiens
7 OCLM  
Affinity Capture-MS Homo sapiens
8 AVIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KIF14 9928
Affinity Capture-MS Homo sapiens
10 ATP6V1B2 526
Co-fractionation Homo sapiens
11 PRNP 5621
Affinity Capture-MS Homo sapiens
12 SSH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
14 ECT2 1894
Affinity Capture-MS Homo sapiens
15 ABRA  
Affinity Capture-MS Homo sapiens
16 RLIM 51132
Affinity Capture-MS Homo sapiens
17 ACTC1 70
Affinity Capture-MS Homo sapiens
18 DBN1 1627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SULT1C3  
Co-fractionation Homo sapiens
20 VAV1 7409
Affinity Capture-MS Homo sapiens
21 KIF20A 10112
Affinity Capture-MS Homo sapiens
22 LSP1 4046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RPL23 9349
Affinity Capture-MS Homo sapiens
24 RUVBL2 10856
Co-fractionation Homo sapiens
25 RBM18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SHMT2 6472
Affinity Capture-RNA Homo sapiens
Co-fractionation Homo sapiens
27 PARK7 11315
Affinity Capture-MS Homo sapiens
28 MYO6 4646
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 APP 351
Reconstituted Complex Homo sapiens
31 MYO1C 4641
Affinity Capture-MS Homo sapiens
32 SCIN 85477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PAM16  
Co-fractionation Homo sapiens
34 SAFB 6294
Co-fractionation Homo sapiens
35 CAPZB 832
Affinity Capture-MS Homo sapiens
36 PTP4A3  
Affinity Capture-MS Homo sapiens
37 MYO1D 4642
Affinity Capture-MS Homo sapiens
38 Ophn1  
Affinity Capture-MS Mus musculus
39 TMEM257  
Affinity Capture-MS Homo sapiens
40 MYC  
Affinity Capture-MS Homo sapiens
41 DYRK1A 1859
Affinity Capture-MS Homo sapiens
42 VARS 7407
Co-fractionation Homo sapiens
43 CXCL6  
Affinity Capture-MS Homo sapiens
44 ABCC1 4363
Co-fractionation Homo sapiens
45 CIT 11113
Affinity Capture-MS Homo sapiens
46 GAGE5  
Affinity Capture-MS Homo sapiens
47 RRM2B 50484
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 FOS 2353
Proximity Label-MS Homo sapiens
49 PRC1 9055
Affinity Capture-MS Homo sapiens
50 ACTB 60
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PLEKHG1  
Affinity Capture-MS Homo sapiens
52 SF3B3 23450
Co-fractionation Homo sapiens
53 DHX9 1660
Co-fractionation Homo sapiens
54 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
55 PABPC3 5042
Co-fractionation Homo sapiens
56 TEAD1  
Affinity Capture-MS Homo sapiens
57 ACTG1 71
Affinity Capture-MS Homo sapiens
58 ATP6V1E1 529
Co-fractionation Homo sapiens
59 MALL  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMOD2 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Striated Muscle Contraction TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here