Gene description for UBC
Gene name ubiquitin C
Gene symbol UBC
Other names/aliases -
Species Bos taurus
 Database cross references - UBC
ExoCarta ExoCarta_444874
Vesiclepedia VP_444874
Entrez Gene 444874
UniProt P0CH28  
 UBC identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for UBC
Molecular Function
    protein tag activity GO:0031386 IEA
    ubiquitin protein ligase binding GO:0031625 IEA
Biological Process
    protein ubiquitination GO:0016567 IEA
    modification-dependent protein catabolic process GO:0019941 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified UBC in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RABEP1 504785
Affinity Capture-Western Bos taurus
2 RABGEF1 27342
Co-crystal Structure Homo sapiens
3 HGS 9146
Reconstituted Complex Homo sapiens
4 GGA3 23163
Reconstituted Complex Homo sapiens
5 KDR  
Affinity Capture-Western Bos taurus
6 UBC 444874
Co-crystal Structure Bos taurus
Co-crystal Structure Bos taurus
7 SQSTM1 8878
Reconstituted Complex Homo sapiens
8 TOM1 10043
Reconstituted Complex Homo sapiens
9 RABGEF1  
Co-crystal Structure Bos taurus
Affinity Capture-Western Bos taurus
10 TOM1L1 10040
Reconstituted Complex Homo sapiens
11 GGA1  
Affinity Capture-Western Bos taurus
12 STAM 8027
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
View the network image/svg+xml
 Pathways in which UBC is involved
PathwayEvidenceSource
ABC-family proteins mediated transport IEA Reactome
Activated NOTCH1 Transmits Signal to the Nucleus IEA Reactome
activated TAK1 mediates p38 MAPK activation IEA Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins IEA Reactome
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IEA Reactome
Activation of NF-kappaB in B cells IEA Reactome
Adaptive Immune System IEA Reactome
Aerobic respiration and respiratory electron transport IEA Reactome
Aggrephagy IEA Reactome
Alpha-protein kinase 1 signaling pathway IEA Reactome
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome
APC-Cdc20 mediated degradation of Nek2A IEA Reactome
APC/C-mediated degradation of cell cycle proteins IEA Reactome
APC/C:Cdc20 mediated degradation of Cyclin B IEA Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins IEA Reactome
APC/C:Cdc20 mediated degradation of Securin IEA Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 IEA Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint IEA Reactome
Asparagine N-linked glycosylation IEA Reactome
Assembly of the pre-replicative complex IEA Reactome
Asymmetric localization of PCP proteins IEA Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA IEA Reactome
Autodegradation of Cdh1 by Cdh1:APC/C IEA Reactome
Autodegradation of the E3 ubiquitin ligase COP1 IEA Reactome
Autophagy IEA Reactome
Axon guidance IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
C-type lectin receptors (CLRs) IEA Reactome
Calnexin/calreticulin cycle IEA Reactome
Cargo recognition for clathrin-mediated endocytosis IEA Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A IEA Reactome
CDK-mediated phosphorylation and removal of Cdc6 IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cell death signalling via NRAGE, NRIF and NADE IEA Reactome
Cellular response to chemical stress IEA Reactome
Cellular response to hypoxia IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Class I MHC mediated antigen processing & presentation IEA Reactome
Clathrin-mediated endocytosis IEA Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
Cyclin A:Cdk2-associated events at S phase entry IEA Reactome
Cyclin D associated events in G1 IEA Reactome
Cyclin E associated events during G1/S transition IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytosolic sensors of pathogen-associated DNA IEA Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Deactivation of the beta-catenin transactivating complex IEA Reactome
Death Receptor Signaling IEA Reactome
Dectin-1 mediated noncanonical NF-kB signaling IEA Reactome
Degradation of AXIN IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Degradation of DVL IEA Reactome
Degradation of GLI1 by the proteasome IEA Reactome
Deubiquitination IEA Reactome
Developmental Biology IEA Reactome
DNA Damage Bypass IEA Reactome
DNA Damage Recognition in GG-NER IEA Reactome
DNA Double Strand Break Response IEA Reactome
DNA Double-Strand Break Repair IEA Reactome
DNA Repair IEA Reactome
DNA Replication IEA Reactome
DNA Replication Pre-Initiation IEA Reactome
Downregulation of ERBB2 signaling IEA Reactome
Downregulation of ERBB2:ERBB3 signaling IEA Reactome
Downregulation of ERBB4 signaling IEA Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity IEA Reactome
Downregulation of TGF-beta receptor signaling IEA Reactome
Downstream signaling events of B Cell Receptor (BCR) IEA Reactome
Downstream TCR signaling IEA Reactome
Dual Incision in GG-NER IEA Reactome
Dual incision in TC-NER IEA Reactome
E3 ubiquitin ligases ubiquitinate target proteins IEA Reactome
EGFR downregulation IEA Reactome
Endosomal Sorting Complex Required For Transport (ESCRT) IEA Reactome
ER Quality Control Compartment (ERQC) IEA Reactome
Fanconi Anemia Pathway IEA Reactome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis IEA Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated NF-kB activation IEA Reactome
FLT3 Signaling IEA Reactome
Formation of Incision Complex in GG-NER IEA Reactome
Formation of TC-NER Pre-Incision Complex IEA Reactome
G1 Phase IEA Reactome
G1/S DNA Damage Checkpoints IEA Reactome
G1/S Transition IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M Transition IEA Reactome
Gap-filling DNA repair synthesis and ligation in GG-NER IEA Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
GLI3 is processed to GLI3R by the proteasome IEA Reactome
Global Genome Nucleotide Excision Repair (GG-NER) IEA Reactome
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 IEA Reactome
HDR through Homologous Recombination (HRR) IEA Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) IEA Reactome
Hedgehog 'off' state IEA Reactome
Hedgehog 'on' state IEA Reactome
Hedgehog ligand biogenesis IEA Reactome
Homology Directed Repair IEA Reactome
IKK complex recruitment mediated by RIP1 IEA Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Innate Immune System IEA Reactome
Interferon alpha/beta signaling IEA Reactome
Interferon Signaling IEA Reactome
Interleukin-1 family signaling IEA Reactome
Interleukin-1 signaling IEA Reactome
Interleukin-17 signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Intracellular signaling by second messengers IEA Reactome
IRAK2 mediated activation of TAK1 complex IEA Reactome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation IEA Reactome
Iron uptake and transport IEA Reactome
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IEA Reactome
Josephin domain DUBs IEA Reactome
KEAP1-NFE2L2 pathway IEA Reactome
M Phase IEA Reactome
Macroautophagy IEA Reactome
MAP kinase activation IEA Reactome
MAP3K8 (TPL2)-dependent MAPK1/3 activation IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
MAPK6/MAPK4 signaling IEA Reactome
Membrane Trafficking IEA Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA IEA Reactome
Metalloprotease DUBs IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle IEA Reactome
Neddylation IEA Reactome
Negative regulation of FGFR1 signaling IEA Reactome
Negative regulation of FGFR2 signaling IEA Reactome
Negative regulation of FGFR3 signaling IEA Reactome
Negative regulation of FGFR4 signaling IEA Reactome
Negative regulation of FLT3 IEA Reactome
Negative regulation of MAPK pathway IEA Reactome
Negative regulation of MET activity IEA Reactome
Negative regulators of DDX58/IFIH1 signaling IEA Reactome
Nervous system development IEA Reactome
NF-kB is activated and signals survival IEA Reactome
NIK-->noncanonical NF-kB signaling IEA Reactome
NOD1/2 Signaling Pathway IEA Reactome
NRIF signals cell death from the nucleus IEA Reactome
Nuclear events mediated by NFE2L2 IEA Reactome
Nucleotide Excision Repair IEA Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways IEA Reactome
Orc1 removal from chromatin IEA Reactome
Ovarian tumor domain proteases IEA Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha IEA Reactome
p53-Dependent G1 DNA Damage Response IEA Reactome
p53-Dependent G1/S DNA damage checkpoint IEA Reactome
p53-Independent DNA Damage Response IEA Reactome
p53-Independent G1/S DNA damage checkpoint IEA Reactome
p75 NTR receptor-mediated signalling IEA Reactome
p75NTR recruits signalling complexes IEA Reactome
p75NTR signals via NF-kB IEA Reactome
PCP/CE pathway IEA Reactome
Peroxisomal protein import IEA Reactome
Pexophagy IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Plasma lipoprotein assembly, remodeling, and clearance IEA Reactome
Plasma lipoprotein clearance IEA Reactome
Post-translational protein modification IEA Reactome
Processing of DNA double-strand break ends IEA Reactome
Programmed Cell Death IEA Reactome
Protein localization IEA Reactome
Protein ubiquitination IEA Reactome
PTEN Regulation IEA Reactome
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 IEA Reactome
Pyruvate metabolism IEA Reactome
RAF/MAP kinase cascade IEA Reactome
RAS processing IEA Reactome
Recognition of DNA damage by PCNA-containing replication complex IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks IEA Reactome
Regulated Necrosis IEA Reactome
Regulation of APC/C activators between G1/S and early anaphase IEA Reactome
Regulation of BACH1 activity IEA Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Regulation of FZD by ubiquitination IEA Reactome
Regulation of innate immune responses to cytosolic DNA IEA Reactome
Regulation of mitotic cell cycle IEA Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements IEA Reactome
Regulation of necroptotic cell death IEA Reactome
Regulation of NF-kappa B signaling IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
Regulation of PTEN localization IEA Reactome
Regulation of PTEN stability and activity IEA Reactome
Regulation of pyruvate metabolism IEA Reactome
Regulation of RUNX2 expression and activity IEA Reactome
Regulation of RUNX3 expression and activity IEA Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 IEA Reactome
Regulation of TNFR1 signaling IEA Reactome
Regulation of TP53 Activity IEA Reactome
Regulation of TP53 Activity through Methylation IEA Reactome
Regulation of TP53 Activity through Phosphorylation IEA Reactome
Regulation of TP53 Degradation IEA Reactome
Regulation of TP53 Expression and Degradation IEA Reactome
RIPK1-mediated regulated necrosis IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
S Phase IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 IEA Reactome
SCF-beta-TrCP mediated degradation of Emi1 IEA Reactome
Selective autophagy IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by EGFR IEA Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB4 IEA Reactome
Signaling by FGFR IEA Reactome
Signaling by FGFR1 IEA Reactome
Signaling by FGFR2 IEA Reactome
Signaling by FGFR3 IEA Reactome
Signaling by FGFR4 IEA Reactome
Signaling by Hedgehog IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by MET IEA Reactome
Signaling by Non-Receptor Tyrosine Kinases IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by PTK6 IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGFB family members IEA Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by WNT IEA Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription IEA Reactome
Spry regulation of FGF signaling IEA Reactome
Stabilization of p53 IEA Reactome
Switching of origins to a post-replicative state IEA Reactome
Synthesis of active ubiquitin: roles of E1 and E2 enzymes IEA Reactome
Synthesis of DNA IEA Reactome
TAK1-dependent IKK and NF-kappa-B activation IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCR signaling IEA Reactome
Termination of translesion DNA synthesis IEA Reactome
TGF-beta receptor signaling activates SMADs IEA Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IEA Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint IEA Reactome
TNF signaling IEA Reactome
TNFR1-induced NF-kappa-B signaling pathway IEA Reactome
TNFR2 non-canonical NF-kB pathway IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
TRAF6-mediated induction of TAK1 complex within TLR4 complex IEA Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) IEA Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transcriptional regulation by RUNX3 IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome
Translesion Synthesis by POLH IEA Reactome
Translesion synthesis by POLI IEA Reactome
Translesion synthesis by POLK IEA Reactome
Translesion synthesis by REV1 IEA Reactome
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template IEA Reactome
Transport of small molecules IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome
Ub-specific processing proteases IEA Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A IEA Reactome
Ubiquitin-dependent degradation of Cyclin D IEA Reactome
UCH proteinases IEA Reactome
Vesicle-mediated transport IEA Reactome
VLDLR internalisation and degradation IEA Reactome





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