Experiment description of studies that identified CCZ1 in sEVs

1 Experiment ID 488 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 36408942     Organism Homo sapiens Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." Journal name Proteomics Publication year 2023 Sample Mesenchymal stem cells Sample name UCMSC Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 834 MISEV standards ✔ EM Biophysical techniques ✔ LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35333565     Organism Homo sapiens Experiment description LAMP2A regulates the loading of proteins into exosomes Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" Journal name Sci Adv Publication year 2022 Sample Retinal pigment epithelial cells Sample name ARPE-19 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

3 Experiment ID 835 MISEV standards ✔ EM Biophysical techniques ✔ CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35333565     Organism Homo sapiens Experiment description LAMP2A regulates the loading of proteins into exosomes Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" Journal name Sci Adv Publication year 2022 Sample Retinal pigment epithelial cells Sample name ARPE-19 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

Protein-protein interactions for CCZ1

Protein Interactor ExoCarta ID Identification method PubMed Species 1 KIF16B 55614 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 2 ABHD17A 81926 Affinity Capture-MS Homo sapiens 3 VWA2 340706 Affinity Capture-MS Homo sapiens 4 LYRM5   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 5 SPATA5L1 79029 Affinity Capture-MS Homo sapiens 6 SNX27 81609 Affinity Capture-MS Homo sapiens 7 FAM167A   Affinity Capture-MS Homo sapiens 8 NPAS1   Affinity Capture-MS Homo sapiens 9 KLK15   Affinity Capture-MS Homo sapiens 10 CCIN   Affinity Capture-MS Homo sapiens 11 CCL3   Affinity Capture-MS Homo sapiens 12 TNFSF10 8743 Affinity Capture-MS Homo sapiens 13 SPHK1 8877 Affinity Capture-MS Homo sapiens 14 RNF181   Affinity Capture-MS Homo sapiens 15 NPRL3   Affinity Capture-MS Homo sapiens 16 BAG2 9532 Affinity Capture-MS Homo sapiens 17 S100A6 6277 Affinity Capture-MS Homo sapiens 18 D2HGDH 728294 Affinity Capture-MS Homo sapiens 19 RARRES3   Affinity Capture-MS Homo sapiens 20 SULT1C4   Affinity Capture-MS Homo sapiens 21 C19orf66   Affinity Capture-MS Homo sapiens 22 C9orf72   Affinity Capture-MS Homo sapiens 23 FYCO1 79443 Affinity Capture-MS Homo sapiens 24 KLHDC2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 25 METTL21B   Affinity Capture-MS Homo sapiens 26 KLHL34   Affinity Capture-MS Homo sapiens 27 PPAT 5471 Affinity Capture-MS Homo sapiens 28 CACNB1   Affinity Capture-MS Homo sapiens 29 HDHD1   Affinity Capture-MS Homo sapiens 30 SP6   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 31 MON1B 22879 Affinity Capture-MS Homo sapiens 32 LMO2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 33 CAPZB 832 Affinity Capture-MS Homo sapiens 34 RPA3 6119 Proximity Label-MS Homo sapiens 35 DHFR 1719 Affinity Capture-MS Homo sapiens 36 UPP2   Affinity Capture-MS Homo sapiens 37 DNAI2   Affinity Capture-MS Homo sapiens 38 LRRC29   Affinity Capture-MS Homo sapiens 39 C12orf74   Affinity Capture-MS Homo sapiens 40 SIPA1L2   Affinity Capture-MS Homo sapiens 41 GPR45   Affinity Capture-MS Homo sapiens 42 RPS14 6208 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 43 CCZ1B 221960 Affinity Capture-MS Homo sapiens 44 FAM174A 345757 Affinity Capture-MS Homo sapiens 45 THBS3 7059 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 46 RCCD1   Affinity Capture-MS Homo sapiens 47 CDK20   Affinity Capture-MS Homo sapiens 48 PRPF40A 55660 Affinity Capture-MS Homo sapiens 49 UBXN6 80700 Affinity Capture-MS Homo sapiens 50 PRKAG3   Affinity Capture-MS Homo sapiens 51 SF3B3 23450 Affinity Capture-MS Homo sapiens 52 KBTBD4   Affinity Capture-MS Homo sapiens 53 CCZ1 51622 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 54 SPINT2 10653 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 55 INF2 64423 Affinity Capture-MS Homo sapiens 56 C18orf8 29919 Affinity Capture-MS Homo sapiens 57 CEBPA   Protein-peptide Homo sapiens 58 CDC5L 988 Affinity Capture-MS Homo sapiens 59 CAPN2 824 Affinity Capture-MS Homo sapiens 60 KLHL14 57565 Affinity Capture-MS Homo sapiens View the network

Pathways in which CCZ1 is involved

No pathways found