Experiment description of studies that identified EPB41L4B in sEVs

1 Experiment ID 207 MISEV standards ✔ Biophysical techniques ✔ Enriched markers ✔ Negative markers ✔ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DKO-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

2 Experiment ID 208 MISEV standards ✔ Biophysical techniques ✔ Enriched markers ✔ Negative markers ✔ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name Dks-8 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 209 MISEV standards ✘ Biophysical techniques ✔ Enriched markers ✔ Negative markers ✔ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DLD-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

4 Experiment ID 1203 MISEV standards ✔ Biophysical techniques ✔ Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 34887515     Organism Homo sapiens Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ." Journal name Nat Cell Biol Publication year 2021 Sample Colorectal cancer cells Sample name DiFi Isolation/purification methods Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Western blotting Mass spectrometry RNA sequencing

Protein-protein interactions for EPB41L4B

Protein Interactor ExoCarta ID Identification method PubMed Species 1 RPL11 6135 Affinity Capture-MS Homo sapiens 2 Haus1   Affinity Capture-MS Mus musculus 3 ANLN 54443 Affinity Capture-MS Homo sapiens 4 RNF43   Proximity Label-MS Homo sapiens 5 SURF6   Affinity Capture-MS Homo sapiens 6 LLGL2 3993 Affinity Capture-MS Homo sapiens 7 LAMC3   Two-hybrid Homo sapiens 8 RAB35 11021 Proximity Label-MS Homo sapiens 9 Vps28 66914 Affinity Capture-MS Mus musculus 10 SETD1A 9739 Affinity Capture-MS Homo sapiens 11 DGCR8   Affinity Capture-MS Homo sapiens 12 RPS19 6223 Affinity Capture-MS Homo sapiens 13 TRAF2 7186 Affinity Capture-MS Homo sapiens 14 OCLN 100506658 Proximity Label-MS Homo sapiens 15 ABT1 29777 Affinity Capture-MS Homo sapiens 16 RPL7A 6130 Affinity Capture-MS Homo sapiens 17 KIF14 9928 Affinity Capture-MS Homo sapiens 18 ERP44 23071 Affinity Capture-MS Homo sapiens 19 HSPA8 3312 Affinity Capture-MS Homo sapiens 20 RPL3 6122 Affinity Capture-MS Homo sapiens 21 GJA1 2697 Proximity Label-MS Homo sapiens 22 ATE1 11101 Affinity Capture-MS Homo sapiens 23 CWC22 57703 Affinity Capture-MS Homo sapiens 24 BIRC2   Affinity Capture-MS Homo sapiens 25 CXXC1   Affinity Capture-MS Homo sapiens 26 RPSAP58 388524 Affinity Capture-MS Homo sapiens 27 SRSF1 6426 Affinity Capture-MS Homo sapiens 28 RPL13 6137 Affinity Capture-MS Homo sapiens 29 MRFAP1   Affinity Capture-MS Homo sapiens 30 CAMK2D 817 Affinity Capture-MS Homo sapiens 31 NPM3 10360 Affinity Capture-MS Homo sapiens 32 PGAM4 441531 Affinity Capture-MS Homo sapiens 33 RPS8 6202 Affinity Capture-MS Homo sapiens 34 GJD3   Proximity Label-MS Homo sapiens 35 RPL14 9045 Affinity Capture-MS Homo sapiens 36 PPIA 5478 Affinity Capture-MS Homo sapiens 37 ARF6 382 Proximity Label-MS Homo sapiens 38 ELAVL1 1994 Affinity Capture-RNA Homo sapiens 39 CXADR 1525 Proximity Label-MS Homo sapiens 40 RPS10 6204 Affinity Capture-MS Homo sapiens 41 C11orf52 91894 Proximity Label-MS Homo sapiens 42 WAPAL   Affinity Capture-MS Homo sapiens 43 LYN 4067 Proximity Label-MS Homo sapiens 44 ZC3H10   Affinity Capture-MS Homo sapiens 45 KIAA0101   Affinity Capture-MS Homo sapiens 46 CDC42 998 Affinity Capture-MS Homo sapiens 47 SRSF6 6431 Affinity Capture-MS Homo sapiens 48 UFL1 23376 Affinity Capture-MS Homo sapiens 49 Atp5a1 11946 Affinity Capture-MS Mus musculus 50 NEIL1   Affinity Capture-MS Homo sapiens 51 HIST1H2AM 8336 Affinity Capture-MS Homo sapiens 52 HIST1H1A 3024 Affinity Capture-MS Homo sapiens 53 CDH1 999 Proximity Label-MS Homo sapiens 54 EPHA2 1969 Proximity Label-MS Homo sapiens 55 PARD6B 84612 Affinity Capture-MS Homo sapiens 56 KIF22   Affinity Capture-MS Homo sapiens 57 RPL31 6160 Affinity Capture-MS Homo sapiens 58 EAF1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 59 ZCCHC10   Affinity Capture-MS Homo sapiens 60 HIST1H1E 3008 Affinity Capture-MS Homo sapiens 61 RPS6 6194 Affinity Capture-MS Homo sapiens 62 ZNF121   Affinity Capture-MS Homo sapiens 63 ARRDC3 57561 Affinity Capture-MS Homo sapiens 64 DDRGK1 65992 Affinity Capture-MS Homo sapiens 65 RPL4 6124 Affinity Capture-MS Homo sapiens 66 KRAS 3845 Proximity Label-MS Homo sapiens 67 RPLP0 6175 Affinity Capture-MS Homo sapiens 68 RAB21 23011 Affinity Capture-MS Homo sapiens 69 MAGEB2 4113 Affinity Capture-MS Homo sapiens 70 Gsk3b   Affinity Capture-MS Mus musculus 71 PRKRA 8575 Affinity Capture-MS Homo sapiens 72 CAMK2B 816 Affinity Capture-MS Homo sapiens 73 CASQ2 845 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens View the network

Pathways in which EPB41L4B is involved

No pathways found