Gene description for LZTFL1
Gene name leucine zipper transcription factor-like 1
Gene symbol LZTFL1
Other names/aliases BBS17
Species Homo sapiens
 Database cross references - LZTFL1
ExoCarta ExoCarta_54585
Vesiclepedia VP_54585
Entrez Gene 54585
HGNC 6741
MIM 606568
UniProt Q9NQ48  
 LZTFL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LZTFL1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein-containing complex binding GO:0044877 IDA
Biological Process
    spermatogenesis GO:0007283 IEA
    flagellated sperm motility GO:0030317 IEA
    negative regulation of protein localization to cilium GO:1903565 IBA
    negative regulation of protein localization to cilium GO:1903565 IMP
    negative regulation of protein localization to ciliary membrane GO:1903568 IMP
Subcellular Localization
    manchette GO:0002177 IEA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cilium GO:0005929 IEA
 Experiment description of studies that identified LZTFL1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LZTFL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FZD5 7855
Two-hybrid Homo sapiens
2 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
3 SH3PXD2B 285590
Co-fractionation Homo sapiens
4 PHB2 11331
Affinity Capture-MS Homo sapiens
5 TSNAXIP1 55815
Affinity Capture-MS Homo sapiens
6 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 TMEM241  
Affinity Capture-MS Homo sapiens
8 PES1 23481
Co-fractionation Homo sapiens
9 PELI2 57161
Two-hybrid Homo sapiens
10 LZTFL1 54585
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 UBXN7 26043
Co-fractionation Homo sapiens
12 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EHHADH 1962
Two-hybrid Homo sapiens
14 SC5D 6309
Affinity Capture-MS Homo sapiens
15 BBS5 129880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ROCK2 9475
Affinity Capture-MS Homo sapiens
17 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
18 SEPSECS  
Affinity Capture-MS Homo sapiens
19 TRIM68 55128
Two-hybrid Homo sapiens
20 IQCF1  
Affinity Capture-MS Homo sapiens
21 BUB3 9184
Affinity Capture-MS Homo sapiens
22 DDX58 23586
Affinity Capture-RNA Homo sapiens
23 PSMA1 5682
Two-hybrid Homo sapiens
24 APEX1 328
Affinity Capture-RNA Homo sapiens
25 CEP250 11190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PSPC1 55269
Co-fractionation Homo sapiens
27 SERBP1 26135
Affinity Capture-MS Homo sapiens
28 BBS1 582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GTF2E2  
Affinity Capture-MS Homo sapiens
30 BBS9 27241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RPS7 6201
Cross-Linking-MS (XL-MS) Homo sapiens
32 TTC8 123016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SH3GLB2 56904
Co-fractionation Homo sapiens
34 BLMH 642
Co-fractionation Homo sapiens
35 BBS4 585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MOB1A 55233
Two-hybrid Homo sapiens
37 RPUSD2  
Co-fractionation Homo sapiens
38 TMEM38A 79041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 BBS2 583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 WDYHV1  
Two-hybrid Homo sapiens
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