Gene description for BBS2
Gene name Bardet-Biedl syndrome 2
Gene symbol BBS2
Other names/aliases BBS
Species Homo sapiens
 Database cross references - BBS2
ExoCarta ExoCarta_583
Vesiclepedia VP_583
Entrez Gene 583
HGNC 967
MIM 606151
UniProt Q9BXC9  
 BBS2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BBS2
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
Biological Process
    sperm axoneme assembly GO:0007288 ISS
    visual perception GO:0007601 IMP
    protein localization GO:0008104 ISS
    gene expression GO:0010467 IEA
    negative regulation of gene expression GO:0010629 IEA
    artery smooth muscle contraction GO:0014824 IEA
    striatum development GO:0021756 ISS
    hippocampus development GO:0021766 ISS
    cerebral cortex development GO:0021987 ISS
    adult behavior GO:0030534 ISS
    melanosome transport GO:0032402 ISS
    protein localization to organelle GO:0033365 ISS
    negative regulation of appetite by leptin-mediated signaling pathway GO:0038108 ISS
    negative regulation of multicellular organism growth GO:0040015 ISS
    positive regulation of multicellular organism growth GO:0040018 IEA
    vasodilation GO:0042311 IEA
    Golgi to plasma membrane protein transport GO:0043001 IMP
    fat cell differentiation GO:0045444 ISS
    photoreceptor cell maintenance GO:0045494 ISS
    brain morphogenesis GO:0048854 ISS
    cartilage development GO:0051216 IEA
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 ISS
    cilium assembly GO:0060271 NAS
    regulation of cilium beat frequency involved in ciliary motility GO:0060296 ISS
    non-motile cilium assembly GO:1905515 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    microvillus GO:0005902 IEA
    membrane GO:0016020 IBA
    motile cilium GO:0031514 IBA
    motile cilium GO:0031514 IDA
    stereocilium GO:0032420 IEA
    centriolar satellite GO:0034451 IEA
    BBSome GO:0034464 IBA
    BBSome GO:0034464 IDA
    BBSome GO:0034464 IMP
    BBSome GO:0034464 IPI
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
    neuron projection GO:0043005 IBA
    ciliary membrane GO:0060170 IDA
 Experiment description of studies that identified BBS2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BBS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K2 5605
Affinity Capture-MS Homo sapiens
2 WHAMMP3  
Affinity Capture-MS Homo sapiens
3 FBXW5  
Affinity Capture-MS Homo sapiens
4 LMO4  
Two-hybrid Homo sapiens
5 FAM167A  
Affinity Capture-MS Homo sapiens
6 CLUAP1 23059
Affinity Capture-MS Homo sapiens
7 PSME3 10197
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 LZTFL1 54585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 COMMD5 28991
Affinity Capture-MS Homo sapiens
11 DNAJB2 3300
Proximity Label-MS Homo sapiens
12 HDHD1  
Affinity Capture-MS Homo sapiens
13 BBS5 129880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 PCK2 5106
Affinity Capture-MS Homo sapiens
16 GUCY1B3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RBFOX1 54715
Affinity Capture-MS Homo sapiens
18 GLIS2  
Affinity Capture-Western Homo sapiens
19 SPG11 80208
Affinity Capture-MS Homo sapiens
20 LPCAT1 79888
Affinity Capture-MS Homo sapiens
21 ABLIM3 22885
Affinity Capture-MS Homo sapiens
22 ENDOV  
Affinity Capture-MS Homo sapiens
23 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 BBS1 582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 BBS9 27241
Affinity Capture-MS Homo sapiens
26 TTC8 123016
Affinity Capture-MS Homo sapiens
27 HNRNPF 3185
Two-hybrid Homo sapiens
28 THBS3 7059
Affinity Capture-MS Homo sapiens
29 NME3 4832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 BBS4 585
Affinity Capture-MS Homo sapiens
31 UPP1 7378
Affinity Capture-MS Homo sapiens
32 RBPMS 11030
Two-hybrid Homo sapiens
33 C16orf59 80178
Affinity Capture-MS Homo sapiens
34 SOHLH1  
Affinity Capture-MS Homo sapiens
35 FAM73B  
Affinity Capture-MS Homo sapiens
36 NRF1 4899
Two-hybrid Homo sapiens
37 KLHL14 57565
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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