Gene description for INPP5E
Gene name inositol polyphosphate-5-phosphatase, 72 kDa
Gene symbol INPP5E
Other names/aliases CORS1
CPD4
JBTS1
MORMS
PPI5PIV
Species Homo sapiens
 Database cross references - INPP5E
ExoCarta ExoCarta_56623
Vesiclepedia VP_56623
Entrez Gene 56623
HGNC 21474
MIM 613037
UniProt Q9NRR6  
 INPP5E identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for INPP5E
Molecular Function
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IBA
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 TAS
    inositol-polyphosphate 5-phosphatase activity GO:0004445 TAS
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0016314 IEA
    phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity GO:0034485 IEA
    phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity GO:0043813 IEA
Biological Process
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    negative regulation of translation GO:0017148 IEA
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA
    phosphatidylinositol dephosphorylation GO:0046856 IBA
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IEA
    cilium assembly GO:0060271 IEA
    response to inositol GO:1902140 IEA
    negative regulation of protein localization to cilium GO:1903565 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    ruffle GO:0001726 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    Golgi apparatus GO:0005794 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    cilium GO:0005929 TAS
    axoneme GO:0005930 IBA
    axoneme GO:0005930 IDA
    Golgi cisterna membrane GO:0032580 IEA
 Experiment description of studies that identified INPP5E in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for INPP5E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 DENND4C 55667
Affinity Capture-MS Homo sapiens
4 LRFN1  
Affinity Capture-MS Homo sapiens
5 SH3RF3  
Affinity Capture-MS Homo sapiens
6 HDAC4  
Affinity Capture-MS Homo sapiens
7 ZBTB21  
Affinity Capture-MS Homo sapiens
8 GIGYF2 26058
Affinity Capture-MS Homo sapiens
9 STARD13 90627
Affinity Capture-MS Homo sapiens
10 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
11 DCLK1 9201
Affinity Capture-MS Homo sapiens
12 KSR1  
Affinity Capture-MS Homo sapiens
13 KIAA1804  
Affinity Capture-MS Homo sapiens
14 RTKN 6242
Affinity Capture-MS Homo sapiens
15 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DENND1A 57706
Affinity Capture-MS Homo sapiens
17 PPM1H  
Affinity Capture-MS Homo sapiens
18 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 OSBPL6  
Affinity Capture-MS Homo sapiens
20 MEX3A  
Affinity Capture-RNA Homo sapiens
21 NAV1 89796
Affinity Capture-MS Homo sapiens
22 LIMA1 51474
Affinity Capture-MS Homo sapiens
23 RPTOR 57521
Affinity Capture-MS Homo sapiens
24 YWHAZ 7534
Affinity Capture-MS Homo sapiens
25 NF1 4763
Affinity Capture-MS Homo sapiens
26 SRGAP2 23380
Affinity Capture-MS Homo sapiens
27 MAGI1  
Affinity Capture-MS Homo sapiens
28 CAMSAP2  
Affinity Capture-MS Homo sapiens
29 RALGPS2 55103
Affinity Capture-MS Homo sapiens
30 CWC25 54883
Affinity Capture-MS Homo sapiens
31 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
32 MTFR1L 56181
Affinity Capture-MS Homo sapiens
33 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
34 EIF4E2  
Affinity Capture-MS Homo sapiens
35 TESK2  
Affinity Capture-MS Homo sapiens
36 PDE6D 5147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 KIF13B 23303
Affinity Capture-MS Homo sapiens
38 CDC25C  
Affinity Capture-MS Homo sapiens
39 RPGR  
Affinity Capture-MS Homo sapiens
40 KIF1C 10749
Affinity Capture-MS Homo sapiens
41 HDAC7  
Affinity Capture-MS Homo sapiens
42 CBY1  
Affinity Capture-MS Homo sapiens
43 PTPN13 5783
Affinity Capture-MS Homo sapiens
44 DENND4A 10260
Affinity Capture-MS Homo sapiens
45 TRIP4 9325
Affinity Capture-MS Homo sapiens
46 GIGYF1  
Affinity Capture-MS Homo sapiens
47 DCAF7 10238
Affinity Capture-MS Homo sapiens
48 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
49 RASAL2 9462
Affinity Capture-MS Homo sapiens
50 ZNF638 27332
Affinity Capture-MS Homo sapiens
51 RAB11FIP2  
Affinity Capture-MS Homo sapiens
52 LPIN3 64900
Affinity Capture-MS Homo sapiens
53 CGN  
Affinity Capture-MS Homo sapiens
54 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 NADK 65220
Affinity Capture-MS Homo sapiens
56 MAST3  
Affinity Capture-MS Homo sapiens
57 TIAM1  
Affinity Capture-MS Homo sapiens
58 PHLDB2 90102
Affinity Capture-MS Homo sapiens
59 TANC2  
Affinity Capture-MS Homo sapiens
60 KCTD3  
Affinity Capture-MS Homo sapiens
61 CEP170 9859
Affinity Capture-MS Homo sapiens
62 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
63 PTPN14 5784
Affinity Capture-MS Homo sapiens
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