Gene description for KIF13B
Gene name kinesin family member 13B
Gene symbol KIF13B
Other names/aliases GAKIN
Species Homo sapiens
 Database cross references - KIF13B
ExoCarta ExoCarta_23303
Vesiclepedia VP_23303
Entrez Gene 23303
HGNC 14405
MIM 607350
UniProt Q9NQT8  
 KIF13B identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for KIF13B
Molecular Function
    microtubule motor activity GO:0003777 IBA
    microtubule motor activity GO:0003777 NAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IBA
    ATP hydrolysis activity GO:0016887 IBA
    protein kinase binding GO:0019901 IPI
    14-3-3 protein binding GO:0071889 IDA
Biological Process
    protein targeting GO:0006605 TAS
    microtubule-based movement GO:0007018 IBA
    microtubule-based movement GO:0007018 TAS
    signal transduction GO:0007165 NAS
    T cell activation GO:0042110 NAS
    regulation of axonogenesis GO:0050770 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IBA
    axon GO:0030424 IDA
 Experiment description of studies that identified KIF13B in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KIF13B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC4  
Affinity Capture-MS Homo sapiens
2 KIF23 9493
Affinity Capture-MS Homo sapiens
3 KSR1  
Affinity Capture-MS Homo sapiens
4 RALGPS2 55103
Affinity Capture-MS Homo sapiens
5 DCP1B  
Affinity Capture-MS Homo sapiens
6 SH3BP4 23677
Affinity Capture-MS Homo sapiens
7 KLC3  
Affinity Capture-MS Homo sapiens
8 NAV1 89796
Affinity Capture-MS Homo sapiens
9 CDC25B 994
Affinity Capture-MS Homo sapiens
10 SRGAP2 23380
Affinity Capture-MS Homo sapiens
11 CAMSAP2  
Affinity Capture-MS Homo sapiens
12 CBY1  
Affinity Capture-MS Homo sapiens
13 CWC25 54883
Affinity Capture-MS Homo sapiens
14 CRTC2 200186
Affinity Capture-MS Homo sapiens
15 EIF4E2  
Affinity Capture-MS Homo sapiens
16 MARK2 2011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 MLLT4 4301
Affinity Capture-MS Homo sapiens
18 PAK4 10298
Affinity Capture-MS Homo sapiens
19 ZBTB21  
Affinity Capture-MS Homo sapiens
20 RASAL2 9462
Affinity Capture-MS Homo sapiens
21 ZNF638 27332
Affinity Capture-MS Homo sapiens
22 GAB2 9846
Affinity Capture-MS Homo sapiens
23 TIAM1  
Affinity Capture-MS Homo sapiens
24 PHLDB2 90102
Affinity Capture-MS Homo sapiens
25 PTPN14 5784
Affinity Capture-MS Homo sapiens
26 FGD6  
Affinity Capture-MS Homo sapiens
27 LRFN1  
Affinity Capture-MS Homo sapiens
28 KIAA1804  
Affinity Capture-MS Homo sapiens
29 LAMTOR1 55004
Proximity Label-MS Homo sapiens
30 MELK  
Affinity Capture-MS Homo sapiens
31 TBC1D1 23216
Affinity Capture-MS Homo sapiens
32 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
33 AGAP1  
Affinity Capture-MS Homo sapiens
34 PPP1CA 5499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 CDK16 5127
Affinity Capture-MS Homo sapiens
36 ANKRD34A  
Affinity Capture-MS Homo sapiens
37 USP21  
Affinity Capture-MS Homo sapiens
38 FAM110A  
Affinity Capture-MS Homo sapiens
39 MTFR1L 56181
Affinity Capture-MS Homo sapiens
40 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
41 TESK2  
Affinity Capture-MS Homo sapiens
42 RAB4A 5867
Proximity Label-MS Homo sapiens
43 TGFBI 7045
Affinity Capture-MS Homo sapiens
44 HDAC7  
Affinity Capture-MS Homo sapiens
45 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
46 MYH9 4627
Affinity Capture-MS Homo sapiens
47 NTRK1 4914
Affinity Capture-MS Homo sapiens
48 DCP1A 55802
Affinity Capture-MS Homo sapiens
49 CHEK1  
Affinity Capture-MS Homo sapiens
50 LPIN3 64900
Affinity Capture-MS Homo sapiens
51 BCL6  
Affinity Capture-MS Homo sapiens
52 FAM110B  
Affinity Capture-MS Homo sapiens
53 DLG1 1739
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
54 TANC2  
Affinity Capture-MS Homo sapiens
55 KCTD3  
Affinity Capture-MS Homo sapiens
56 HDAC5 10014
Affinity Capture-MS Homo sapiens
57 DACT3  
Affinity Capture-MS Homo sapiens
58 NADK 65220
Affinity Capture-MS Homo sapiens
59 LARP1 23367
Affinity Capture-MS Homo sapiens
60 RING1 6015
Cross-Linking-MS (XL-MS) Homo sapiens
61 LIMA1 51474
Affinity Capture-MS Homo sapiens
62 KIF1B 23095
Affinity Capture-MS Homo sapiens
63 DCLK1 9201
Affinity Capture-MS Homo sapiens
64 PANK2 80025
Affinity Capture-MS Homo sapiens
65 REEP3 221035
Affinity Capture-MS Homo sapiens
66 OSBPL6  
Affinity Capture-MS Homo sapiens
67 INPP5E 56623
Affinity Capture-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
69 YWHAZ 7534
Affinity Capture-MS Homo sapiens
70 PDIA3 2923
Cross-Linking-MS (XL-MS) Homo sapiens
71 ARF6 382
Affinity Capture-Western Homo sapiens
72 DLG4  
Reconstituted Complex Homo sapiens
73 WEE1 7465
Affinity Capture-MS Homo sapiens
74 SYDE1 85360
Affinity Capture-MS Homo sapiens
75 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
76 CDC25C  
Affinity Capture-MS Homo sapiens
77 KIF1BP 26128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PTPN13 5783
Affinity Capture-MS Homo sapiens
79 GIGYF1  
Affinity Capture-MS Homo sapiens
80 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
81 MICALL1 85377
Affinity Capture-MS Homo sapiens
82 RAB11FIP2  
Affinity Capture-MS Homo sapiens
83 CGN  
Affinity Capture-MS Homo sapiens
84 RNF2  
Cross-Linking-MS (XL-MS) Homo sapiens
85 SF3B3 23450
Two-hybrid Homo sapiens
86 BAIAP2 10458
Affinity Capture-MS Homo sapiens
87 TBC1D25  
Affinity Capture-MS Homo sapiens
88 DENND4C 55667
Affinity Capture-MS Homo sapiens
89 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
90 SH3RF3  
Affinity Capture-MS Homo sapiens
91 GIGYF2 26058
Affinity Capture-MS Homo sapiens
92 STARD13 90627
Affinity Capture-MS Homo sapiens
93 TERF2  
Affinity Capture-MS Homo sapiens
94 FAM53C 51307
Affinity Capture-MS Homo sapiens
95 CCDC85A  
Affinity Capture-MS Homo sapiens
96 RTKN 6242
Affinity Capture-MS Homo sapiens
97 DENND1A 57706
Affinity Capture-MS Homo sapiens
98 PPM1H  
Affinity Capture-MS Homo sapiens
99 MEN1 4221
Affinity Capture-MS Homo sapiens
100 SRSF12  
Affinity Capture-MS Homo sapiens
101 RPTOR 57521
Affinity Capture-MS Homo sapiens
102 SEPT10 151011
Proximity Label-MS Homo sapiens
103 MAGI1  
Affinity Capture-MS Homo sapiens
104 EDC3 80153
Affinity Capture-MS Homo sapiens
105 DDX58 23586
Affinity Capture-RNA Homo sapiens
106 YWHAE 7531
Affinity Capture-MS Homo sapiens
107 UFL1 23376
Affinity Capture-MS Homo sapiens
108 C20orf197  
Affinity Capture-MS Homo sapiens
109 NF1 4763
Affinity Capture-MS Homo sapiens
110 DENND4A 10260
Affinity Capture-MS Homo sapiens
111 RAB11A 8766
Proximity Label-MS Homo sapiens
112 GOT1 2805
Affinity Capture-MS Homo sapiens
113 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
114 CRTC3  
Affinity Capture-MS Homo sapiens
115 CRTC1  
Affinity Capture-MS Homo sapiens
116 KIF1C 10749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 MAST3  
Affinity Capture-MS Homo sapiens
118 RPA2 6118
Proximity Label-MS Homo sapiens
119 CCR1  
Affinity Capture-MS Homo sapiens
120 RPA3 6119
Proximity Label-MS Homo sapiens
121 CAV1 857
Proximity Label-MS Homo sapiens
122 STX17 55014
Affinity Capture-MS Homo sapiens
123 ASB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
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