Gene description for SAA1
Gene name serum amyloid A1
Gene symbol SAA1
Other names/aliases PIG4
SAA
SAA2
TP53I4
Species Homo sapiens
 Database cross references - SAA1
ExoCarta ExoCarta_6288
Vesiclepedia VP_6288
Entrez Gene 6288
HGNC 10513
MIM 104750
UniProt P0DJI8  
 SAA1 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 22723089    
Saliva 19199708    
 Gene ontology annotations for SAA1
Molecular Function
    G protein-coupled receptor binding GO:0001664 IDA
    heparin binding GO:0008201 IEA
Biological Process
    positive regulation of cytokine production GO:0001819 IDA
    acute-phase response GO:0006953 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IDA
    positive regulation of cytosolic calcium ion concentration GO:0007204 NAS
    platelet activation GO:0030168 NAS
    neutrophil chemotaxis GO:0030593 NAS
    positive regulation of interleukin-1 production GO:0032732 NAS
    positive regulation of cell adhesion GO:0045785 IDA
    positive regulation of cell adhesion GO:0045785 NAS
    macrophage chemotaxis GO:0048246 IDA
    lymphocyte chemotaxis GO:0048247 IDA
    regulation of protein secretion GO:0050708 NAS
    negative regulation of inflammatory response GO:0050728 NAS
Subcellular Localization
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    cytoplasmic microtubule GO:0005881 IDA
    high-density lipoprotein particle GO:0034364 IEA
    extracellular exosome GO:0070062 HDA
    endocytic vesicle lumen GO:0071682 TAS
 Experiment description of studies that identified SAA1 in sEVs
1
Experiment ID 146
MISEV standards
EM
Biophysical techniques
HSP70|HSP90|CD9
Enriched markers
HSP90B1
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
2
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SAA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRFN1  
Affinity Capture-MS Homo sapiens
2 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
3 RRP36 88745
Affinity Capture-MS Homo sapiens
4 PRRC2A 7916
Affinity Capture-MS Homo sapiens
5 DIDO1  
Affinity Capture-MS Homo sapiens
6 EMC3 55831
Affinity Capture-MS Homo sapiens
7 PDIA5 10954
Affinity Capture-MS Homo sapiens
8 NUDT12  
Affinity Capture-MS Homo sapiens
9 EMC8 10328
Affinity Capture-MS Homo sapiens
10 CNN1 1264
Cross-Linking-MS (XL-MS) Homo sapiens
11 UTP11L  
Affinity Capture-MS Homo sapiens
12 PRPF38A 84950
Affinity Capture-MS Homo sapiens
13 PHF3  
Affinity Capture-MS Homo sapiens
14 RBMXL1  
Affinity Capture-MS Homo sapiens
15 WDR33 55339
Affinity Capture-MS Homo sapiens
16 EMC4 51234
Affinity Capture-MS Homo sapiens
17 USP36  
Affinity Capture-MS Homo sapiens
18 APOE 348
Cross-Linking-MS (XL-MS) Homo sapiens
19 YLPM1 56252
Affinity Capture-MS Homo sapiens
20 ZC3H4 23211
Affinity Capture-MS Homo sapiens
21 CWC25 54883
Affinity Capture-MS Homo sapiens
22 RAI14 26064
Affinity Capture-MS Homo sapiens
23 SLTM 79811
Affinity Capture-MS Homo sapiens
24 RP9  
Affinity Capture-MS Homo sapiens
25 PPHLN1  
Affinity Capture-MS Homo sapiens
26 SAFB 6294
Affinity Capture-MS Homo sapiens
27 PPP1R9A  
Affinity Capture-MS Homo sapiens
28 SNIP1  
Affinity Capture-MS Homo sapiens
29 SAA2 6289
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
30 SAFB2 9667
Affinity Capture-MS Homo sapiens
31 APOA2 336
Cross-Linking-MS (XL-MS) Homo sapiens
32 EMC7 56851
Affinity Capture-MS Homo sapiens
33 CDK12 51755
Affinity Capture-MS Homo sapiens
34 VKORC1 79001
Two-hybrid Homo sapiens
35 UBTF 7343
Affinity Capture-MS Homo sapiens
36 ZC3H13 23091
Affinity Capture-MS Homo sapiens
37 CACTIN  
Affinity Capture-MS Homo sapiens
38 ARGLU1  
Affinity Capture-MS Homo sapiens
39 MPRIP 23164
Affinity Capture-MS Homo sapiens
40 SAA4 6291
Cross-Linking-MS (XL-MS) Homo sapiens
41 VIMP 55829
Reconstituted Complex Homo sapiens
42 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
43 RSRC1  
Affinity Capture-MS Homo sapiens
44 APOA1 335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
45 LRCH3 84859
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SAA1 is involved
PathwayEvidenceSource
Advanced glycosylation endproduct receptor signaling TAS Reactome
Advanced glycosylation endproduct receptor signaling IEA Reactome
Amyloid fiber formation TAS Reactome
Binding and Uptake of Ligands by Scavenger Receptors TAS Reactome
Class A/1 (Rhodopsin-like receptors) TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Formyl peptide receptors bind formyl peptides and many other ligands TAS Reactome
G alpha (i) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
GPCR downstream signalling TAS Reactome
GPCR ligand binding TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Metabolism of proteins TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Peptide ligand-binding receptors TAS Reactome
Scavenging by Class B Receptors TAS Reactome
Signal Transduction TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Interleukins TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Vesicle-mediated transport TAS Reactome





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