Gene description for SLC7A2
Gene name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Gene symbol SLC7A2
Other names/aliases ATRC2
CAT2
HCAT2
Species Homo sapiens
 Database cross references - SLC7A2
ExoCarta ExoCarta_6542
Vesiclepedia VP_6542
Entrez Gene 6542
HGNC 11060
MIM 601872
UniProt P52569  
 SLC7A2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC7A2
Molecular Function
    L-ornithine transmembrane transporter activity GO:0000064 IBA
    amino acid transmembrane transporter activity GO:0015171 IDA
    amino acid transmembrane transporter activity GO:0015171 TAS
    basic amino acid transmembrane transporter activity GO:0015174 TAS
    L-amino acid transmembrane transporter activity GO:0015179 IDA
    L-lysine transmembrane transporter activity GO:0015189 IBA
    L-arginine transmembrane transporter activity GO:0061459 IBA
    L-arginine transmembrane transporter activity GO:0061459 IDA
Biological Process
    amino acid transport GO:0006865 TAS
    L-amino acid transport GO:0015807 IDA
    amino acid import across plasma membrane GO:0089718 IDA
    L-arginine import across plasma membrane GO:0097638 IBA
    L-arginine import across plasma membrane GO:0097638 IDA
    transport across blood-brain barrier GO:0150104 NAS
    L-alpha-amino acid transmembrane transport GO:1902475 IDA
    L-ornithine transmembrane transport GO:1903352 IBA
    L-lysine transmembrane transport GO:1903401 IEA
    L-arginine transmembrane transport GO:1903826 IDA
    L-arginine transmembrane transport GO:1903826 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell junction GO:0030054 IDA
 Experiment description of studies that identified SLC7A2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC7A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTGIR  
Affinity Capture-MS Homo sapiens
2 GPR17 2840
Affinity Capture-MS Homo sapiens
3 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RAB35 11021
Proximity Label-MS Homo sapiens
7 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 LAMTOR1 55004
Proximity Label-MS Homo sapiens
9 CXCR4 7852
Affinity Capture-MS Homo sapiens
10 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GPR12  
Affinity Capture-MS Homo sapiens
12 GABRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CMTM5  
Affinity Capture-MS Homo sapiens
14 TP53 7157
Synthetic Growth Defect Homo sapiens
15 MARCKS 4082
Proximity Label-MS Homo sapiens
16 LAMP3  
Proximity Label-MS Homo sapiens
17 RAB5A 5868
Proximity Label-MS Homo sapiens
18 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
20 HCST  
Affinity Capture-MS Homo sapiens
21 MFSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 NIPAL1  
Affinity Capture-MS Homo sapiens
23 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 RNF128  
Affinity Capture-MS Homo sapiens
25 RTP2  
Affinity Capture-MS Homo sapiens
26 LAMP1 3916
Proximity Label-MS Homo sapiens
27 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GJA8  
Affinity Capture-MS Homo sapiens
30 TSPAN15 23555
Affinity Capture-MS Homo sapiens
31 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CD40 958
Affinity Capture-MS Homo sapiens
33 LAMP2 3920
Proximity Label-MS Homo sapiens
34 TSPAN10 83882
Affinity Capture-MS Homo sapiens
35 ARF6 382
Proximity Label-MS Homo sapiens
36 FPR1  
Affinity Capture-MS Homo sapiens
37 AQP3  
Affinity Capture-MS Homo sapiens
38 STX4 6810
Proximity Label-MS Homo sapiens
39 C11orf52 91894
Proximity Label-MS Homo sapiens
40 LGALS9 3965
Affinity Capture-MS Homo sapiens
41 LYN 4067
Proximity Label-MS Homo sapiens
42 RAB4A 5867
Proximity Label-MS Homo sapiens
43 VSIG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CYP2C18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 C19orf38  
Affinity Capture-MS Homo sapiens
46 ATP6V0E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ANKRD22  
Affinity Capture-MS Homo sapiens
48 CACNG6  
Affinity Capture-MS Homo sapiens
49 B3GAT1  
Proximity Label-MS Homo sapiens
50 TPST2 8459
Affinity Capture-MS Homo sapiens
51 RAB2A 5862
Proximity Label-MS Homo sapiens
52 SEC62 7095
Proximity Label-MS Homo sapiens
53 DIRAS3  
Proximity Label-MS Homo sapiens
54 LGALS9B 284194
Affinity Capture-MS Homo sapiens
55 RAB11A 8766
Proximity Label-MS Homo sapiens
56 GPR182  
Affinity Capture-MS Homo sapiens
57 RAB3B 5865
Proximity Label-MS Homo sapiens
58 C5AR1  
Affinity Capture-MS Homo sapiens
59 VIPR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RAB5C 5878
Proximity Label-MS Homo sapiens
61 RHOB 388
Proximity Label-MS Homo sapiens
62 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 KRAS 3845
Proximity Label-MS Homo sapiens
64 TSPAN31 6302
Affinity Capture-MS Homo sapiens
65 UPK1A 11045
Affinity Capture-MS Homo sapiens
66 SLC22A4 6583
Affinity Capture-MS Homo sapiens
67 C11orf87  
Affinity Capture-MS Homo sapiens
68 CAV1 857
Proximity Label-MS Homo sapiens
69 TMEM171  
Affinity Capture-MS Homo sapiens
70 RAB7A 7879
Proximity Label-MS Homo sapiens
71 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 NAT8B  
Affinity Capture-MS Homo sapiens
73 OCLN 100506658
Proximity Label-MS Homo sapiens
74 OPALIN  
Affinity Capture-MS Homo sapiens
75 STX6 10228
Proximity Label-MS Homo sapiens
76 CACNG1  
Affinity Capture-MS Homo sapiens
77 AVPR2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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