Gene description for YIPF3
Gene name Yip1 domain family, member 3
Gene symbol YIPF3
Other names/aliases C6orf109
FinGER3
KLIP1
dJ337H4.3
Species Homo sapiens
 Database cross references - YIPF3
ExoCarta ExoCarta_25844
Vesiclepedia VP_25844
Entrez Gene 25844
HGNC 21023
MIM 609775
UniProt Q9GZM5  
 YIPF3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for YIPF3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell differentiation GO:0030154 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IEA
    transport vesicle GO:0030133 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified YIPF3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for YIPF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPM6A 2823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MCM3 4172
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 C5AR1  
Affinity Capture-MS Homo sapiens
5 KRTAP11-1  
Two-hybrid Homo sapiens
6 SYNGR1 9145
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KRTAP9-8  
Two-hybrid Homo sapiens
8 SLC35F5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 NDUFB5 4711
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 BSCL2  
Affinity Capture-MS Homo sapiens
11 SURF4 6836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MFSD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TMEM161B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MFSD8 256471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KRTAP5-9  
Two-hybrid Homo sapiens
16 SLC7A14  
Affinity Capture-MS Homo sapiens
17 SMPDL3B 27293
Affinity Capture-MS Homo sapiens
18 SYVN1 84447
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 FFAR1  
Affinity Capture-MS Homo sapiens
20 CPT1A 1374
Co-fractionation Homo sapiens
21 SLC5A6 8884
Affinity Capture-MS Homo sapiens
22 PTRH2 51651
Affinity Capture-MS Homo sapiens
23 NDUFB9 4715
Affinity Capture-MS Homo sapiens
24 PIGN 23556
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ALG10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 B3GAT1  
Proximity Label-MS Homo sapiens
27 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NDUFB8 4714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 P2RY1  
Affinity Capture-MS Homo sapiens
30 ADCY6 112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 FAM8A1 51439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GINM1 116254
Affinity Capture-MS Homo sapiens
33 B4GALT7 11285
Affinity Capture-MS Homo sapiens
34 OPRM1 4988
Two-hybrid Homo sapiens
35 SLC6A5  
Affinity Capture-MS Homo sapiens
36 SLC43A2 124935
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
38 PCNXL3 399909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KRTAP1-3  
Two-hybrid Homo sapiens
40 PHB 5245
Affinity Capture-MS Homo sapiens
41 NDUFV3 4731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TMEM63C  
Affinity Capture-MS Homo sapiens
43 ATP13A3 79572
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FAM134A 79137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TMEM63B 55362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SLC43A1 8501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TMEM120A 83862
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 F2RL1  
Affinity Capture-MS Homo sapiens
50 KCNK1  
Affinity Capture-MS Homo sapiens
51 FAM213A 84293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 SC5D 6309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TMEM245 23731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 ANXA13 312
Affinity Capture-MS Homo sapiens
55 NDUFS4 4724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ATP8B2 57198
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PLSCR1 5359
Two-hybrid Homo sapiens
58 ADGRL3 23284
Affinity Capture-MS Homo sapiens
59 REEP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 STOM 2040
Affinity Capture-MS Homo sapiens
61 P2RY8  
Affinity Capture-MS Homo sapiens
62 TRIM42  
Two-hybrid Homo sapiens
63 GPR35  
Affinity Capture-MS Homo sapiens
64 OXTR 5021
Two-hybrid Homo sapiens
65 TMEM43 79188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SLC5A4  
Affinity Capture-MS Homo sapiens
67 ATP9A 10079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 S1PR1 1901
Affinity Capture-MS Homo sapiens
69 TP53I11  
Affinity Capture-MS Homo sapiens
70 GPR182  
Affinity Capture-MS Homo sapiens
71 SLC7A2 6542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TMEM259 91304
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 P2RY12 64805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 TMEM56  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CD63 967
Affinity Capture-MS Homo sapiens
76 LMBR1  
Affinity Capture-MS Homo sapiens
77 ELOVL5 60481
Proximity Label-MS Homo sapiens
78 GPR173  
Affinity Capture-MS Homo sapiens
79 HRH1  
Two-hybrid Homo sapiens
80 SPPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 NOTCH2NL 388677
Two-hybrid Homo sapiens
82 CDS2 8760
Affinity Capture-MS Homo sapiens
83 SEC63 11231
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 RHBDD1 84236
Affinity Capture-MS Homo sapiens
85 NIPA2 81614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 GPR141  
Affinity Capture-MS Homo sapiens
88 APLNR  
Affinity Capture-MS Homo sapiens
89 GPAA1 8733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CXCR4 7852
Affinity Capture-MS Homo sapiens
91 MC4R  
Two-hybrid Homo sapiens
92 CAV2 858
Affinity Capture-MS Homo sapiens
93 ND5 4540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 FZD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 TMEM223  
Affinity Capture-MS Homo sapiens
96 KRTAP10-8  
Two-hybrid Homo sapiens
97 APOB 338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 CMKLR1 1240
Affinity Capture-MS Homo sapiens
99 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 SLC22A5 6584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 HSD3B7 80270
Proximity Label-MS Homo sapiens
102 ENDOD1 23052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 NIPAL1  
Affinity Capture-MS Homo sapiens
104 KRTAP10-3  
Two-hybrid Homo sapiens
105 HOXA1 3198
Two-hybrid Homo sapiens
106 SGPP1 81537
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 PIGW  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 SLC35B2 347734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MFSD11  
Affinity Capture-MS Homo sapiens
110 SOAT1 6646
Affinity Capture-MS Homo sapiens
111 ALG8  
Affinity Capture-MS Homo sapiens
112 NDUFB3 4709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 Uso1 56041
Affinity Capture-MS Mus musculus
114 GPR45  
Affinity Capture-MS Homo sapiens
115 CMTM5  
Affinity Capture-MS Homo sapiens
116 ACKR2  
Affinity Capture-MS Homo sapiens
117 YIPF4 84272
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
118 NDUFB6 4712
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 KTN1 3895
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 SLC22A4 6583
Affinity Capture-MS Homo sapiens
121 KRTAP3-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
122 NDUFC2 4718
Affinity Capture-MS Homo sapiens
123 SLC9A6 10479
Affinity Capture-MS Homo sapiens
124 MALL  
Affinity Capture-MS Homo sapiens
125 PTAFR  
Affinity Capture-MS Homo sapiens
126 DRD2  
Two-hybrid Homo sapiens
127 AVPR2  
Affinity Capture-MS Homo sapiens
128 SLC19A2 10560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
130 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 SYNGR2 9144
Affinity Capture-MS Homo sapiens
133 CDS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 SLC5A5 6528
Affinity Capture-MS Homo sapiens
135 SIDT2 51092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 PIEZO1 9780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 INCA1  
Two-hybrid Homo sapiens
139 KRTAP9-4  
Two-hybrid Homo sapiens
140 TMEM120B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 CHRM4  
Two-hybrid Homo sapiens
142 NDUFA12 55967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 UNC93B1 81622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 PIGU 128869
Affinity Capture-MS Homo sapiens
145 AGPAT3 56894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 BRI3BP 140707
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 CHRM3 1131
Two-hybrid Homo sapiens
148 SCN4A  
Affinity Capture-MS Homo sapiens
149 MGAT4B 11282
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 ERGIC2 51290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 GPR52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 RAB2A 5862
Proximity Label-MS Homo sapiens
153 GOLGA5 9950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 KRTAP12-2  
Two-hybrid Homo sapiens
155 SPPL2B 56928
Affinity Capture-MS Homo sapiens
156 RAB7A 7879
Proximity Label-MS Homo sapiens
157 SLC6A8 6535
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 LPAR2 9170
Affinity Capture-MS Homo sapiens
159 EI24  
Affinity Capture-MS Homo sapiens
160 KIR2DL4  
Affinity Capture-MS Homo sapiens
161 VIPR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 RAB5C 5878
Proximity Label-MS Homo sapiens
163 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 WFS1 7466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 CCR6  
Affinity Capture-MS Homo sapiens
166 SLC1A1 6505
Affinity Capture-MS Homo sapiens
167 CAV1 857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 ND4 4538
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 FPR2  
Affinity Capture-MS Homo sapiens
170 C12orf57 113246
Affinity Capture-MS Homo sapiens
171 S1PR4  
Affinity Capture-MS Homo sapiens
172 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which YIPF3 is involved
No pathways found





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