Gene description for FAM134A
Gene name family with sequence similarity 134, member A
Gene symbol FAM134A
Other names/aliases C2orf17
Species Homo sapiens
 Database cross references - FAM134A
ExoCarta ExoCarta_79137
Vesiclepedia VP_79137
Entrez Gene 79137
HGNC 28450
UniProt Q8NC44  
 FAM134A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FAM134A
Molecular Function
    protein binding GO:0005515 IPI
    endoplasmic reticulum-autophagosome adaptor activity GO:0140506 IEA
Biological Process
    endoplasmic reticulum organization GO:0007029 IEA
    collagen catabolic process GO:0030574 IEA
    reticulophagy GO:0061709 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IBA
 Experiment description of studies that identified FAM134A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FAM134A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GOLGA3 2802
Affinity Capture-MS Homo sapiens
2 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 REEP5 7905
Proximity Label-MS Homo sapiens
4 Fam134a  
Affinity Capture-MS Mus musculus
5 ATP5H 10476
Affinity Capture-MS Homo sapiens
6 CHD3 1107
Two-hybrid Homo sapiens
7 GPR17 2840
Affinity Capture-MS Homo sapiens
8 ATP5J 522
Affinity Capture-MS Homo sapiens
9 MRPL33  
Affinity Capture-MS Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 ATP5A1 498
Affinity Capture-MS Homo sapiens
12 TSPAN15 23555
Affinity Capture-MS Homo sapiens
13 ATP5F1 515
Affinity Capture-MS Homo sapiens
14 CHD1L 9557
Affinity Capture-MS Homo sapiens
15 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 KIAA1377  
Two-hybrid Homo sapiens
17 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
18 MAP1LC3B 81631
Two-hybrid Homo sapiens
19 GPR52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CLTA 1211
Affinity Capture-MS Homo sapiens
21 STS 412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HPSE 10855
Affinity Capture-MS Homo sapiens
23 ZDHHC11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 EIF5A 1984
Affinity Capture-MS Homo sapiens
25 PVR 5817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SLC27A2 11001
Affinity Capture-MS Homo sapiens
27 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TSPAN31 6302
Affinity Capture-MS Homo sapiens
29 PRDX2 7001
Affinity Capture-MS Homo sapiens
30 ATP5O 539
Affinity Capture-MS Homo sapiens
31 SLC25A19  
Affinity Capture-MS Homo sapiens
32 ABCD3 5825
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM134A is involved
No pathways found





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