Gene description for UNC93B1
Gene name unc-93 homolog B1 (C. elegans)
Gene symbol UNC93B1
Other names/aliases IIAE1
UNC93
UNC93B
Unc-93B1
Species Homo sapiens
 Database cross references - UNC93B1
ExoCarta ExoCarta_81622
Vesiclepedia VP_81622
Entrez Gene 81622
HGNC 13481
MIM 608204
UniProt Q9H1C4  
 UNC93B1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for UNC93B1
Molecular Function
    protein binding GO:0005515 IPI
    Toll-like receptor binding GO:0035325 IBA
    Toll-like receptor binding GO:0035325 IPI
Biological Process
    cell morphogenesis GO:0000902 IEA
    toll-like receptor signaling pathway GO:0002224 IEA
    T cell antigen processing and presentation GO:0002457 IEA
    intracellular protein transport GO:0006886 IBA
    intracellular protein transport GO:0006886 ISS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IEA
    positive regulation of interleukin-12 production GO:0032735 IEA
    positive regulation of interleukin-6 production GO:0032755 IEA
    toll-like receptor 3 signaling pathway GO:0034138 IBA
    toll-like receptor 3 signaling pathway GO:0034138 IMP
    toll-like receptor 7 signaling pathway GO:0034154 IBA
    toll-like receptor 7 signaling pathway GO:0034154 IMP
    toll-like receptor 9 signaling pathway GO:0034162 IBA
    toll-like receptor 9 signaling pathway GO:0034162 IMP
    toll-like receptor 9 signaling pathway GO:0034162 ISS
    innate immune response GO:0045087 IEA
    defense response to virus GO:0051607 IEA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    lysosome GO:0005764 IBA
    lysosome GO:0005764 ISS
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    endosome GO:0005768 ISS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    early phagosome GO:0032009 ISS
 Experiment description of studies that identified UNC93B1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for UNC93B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C5AR1  
Affinity Capture-MS Homo sapiens
2 STT3A 3703
Affinity Capture-MS Homo sapiens
3 SYNGR1 9145
Affinity Capture-MS Homo sapiens
4 SLC39A4 55630
Affinity Capture-MS Homo sapiens
5 TM9SF2 9375
Affinity Capture-MS Homo sapiens
6 TMEM184A  
Affinity Capture-MS Homo sapiens
7 SURF4 6836
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
8 SPNS1 83985
Affinity Capture-MS Homo sapiens
9 GPR182  
Affinity Capture-MS Homo sapiens
10 CD79A  
Two-hybrid Homo sapiens
11 FFAR1  
Affinity Capture-MS Homo sapiens
12 FFAR3  
Two-hybrid Homo sapiens
13 PIGN 23556
Affinity Capture-MS Homo sapiens
14 LPGAT1 9926
Affinity Capture-MS Homo sapiens
15 P2RY1  
Affinity Capture-MS Homo sapiens
16 C4orf3  
Affinity Capture-MS Homo sapiens
17 SEL1L 6400
Affinity Capture-MS Homo sapiens
18 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 KLRC1  
Two-hybrid Homo sapiens
20 DDOST 1650
Affinity Capture-MS Homo sapiens
21 ATP2A3 489
Affinity Capture-MS Homo sapiens
22 CCDC47 57003
Affinity Capture-MS Homo sapiens
23 F2RL1  
Affinity Capture-MS Homo sapiens
24 SSMEM1  
Two-hybrid Homo sapiens
25 FARSA 2193
Affinity Capture-MS Homo sapiens
26 KCNK1  
Affinity Capture-MS Homo sapiens
27 ACKR2  
Affinity Capture-MS Homo sapiens
28 CLDN7 1366
Two-hybrid Homo sapiens
29 NPC1 4864
Affinity Capture-MS Homo sapiens
30 FASTKD5  
Affinity Capture-MS Homo sapiens
31 IRAK1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
32 TM4SF18  
Two-hybrid Homo sapiens
33 RNF115  
Affinity Capture-Western Homo sapiens
34 ANKHD1 54882
Affinity Capture-MS Homo sapiens
35 PBXIP1 57326
Affinity Capture-MS Homo sapiens
36 SCAMP2 10066
Affinity Capture-MS Homo sapiens
37 CCDC107  
Two-hybrid Homo sapiens
38 UPK1A 11045
Affinity Capture-MS Homo sapiens
39 GPR173  
Affinity Capture-MS Homo sapiens
40 ZACN  
Affinity Capture-MS Homo sapiens
41 CDIPT 10423
Affinity Capture-MS Homo sapiens
42 VIPR2  
Affinity Capture-MS Homo sapiens
43 TTYH1  
Affinity Capture-MS Homo sapiens
44 AIFM1 9131
Affinity Capture-MS Homo sapiens
45 SYNDIG1  
Two-hybrid Homo sapiens
46 ZDHHC12  
Affinity Capture-MS Homo sapiens
47 CMKLR1 1240
Affinity Capture-MS Homo sapiens
48 GOLT1B 51026
Affinity Capture-MS Homo sapiens
49 ERGIC3 51614
Two-hybrid Homo sapiens
50 GPR101  
Two-hybrid Homo sapiens
51 ATP5F1 515
Affinity Capture-MS Homo sapiens
52 AQP3  
Affinity Capture-MS Homo sapiens
53 YIPF5 81555
Affinity Capture-MS Homo sapiens
54 CREB3L1  
Two-hybrid Homo sapiens
55 NXF1 10482
Affinity Capture-RNA Homo sapiens
56 FDFT1 2222
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 TM9SF3 56889
Affinity Capture-MS Homo sapiens
58 LEUTX  
Two-hybrid Homo sapiens
59 SAAL1 113174
Affinity Capture-MS Homo sapiens
60 TSPAN8 7103
Affinity Capture-MS Homo sapiens
61 TMEM237 65062
Two-hybrid Homo sapiens
62 TMCO1 54499
Affinity Capture-MS Homo sapiens
63 CMTM5  
Affinity Capture-MS Homo sapiens
64 ABCC1 4363
Affinity Capture-MS Homo sapiens
65 LIME1 54923
Two-hybrid Homo sapiens
66 ATP5C1 509
Affinity Capture-MS Homo sapiens
67 FATE1  
Two-hybrid Homo sapiens
68 MBOAT7 79143
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
69 ADORA2B  
Affinity Capture-MS Homo sapiens
70 EDNRA 1909
Affinity Capture-MS Homo sapiens
71 ATP5J 522
Affinity Capture-MS Homo sapiens
72 SIDT2 51092
Affinity Capture-MS Homo sapiens
73 SLC16A2  
Two-hybrid Homo sapiens
74 SEMA7A  
Affinity Capture-MS Homo sapiens
75 MFSD4  
Affinity Capture-MS Homo sapiens
76 CLPTM1 1209
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
77 HHLA2  
Two-hybrid Homo sapiens
78 TSPAN15 23555
Affinity Capture-MS Homo sapiens
79 LDLRAD1  
Two-hybrid Homo sapiens
80 B4GAT1 11041
Affinity Capture-MS Homo sapiens
81 EBP  
Two-hybrid Homo sapiens
82 TLR8  
Affinity Capture-MS Homo sapiens
83 GPRC5D  
Two-hybrid Homo sapiens
84 MFF 56947
Two-hybrid Homo sapiens
85 TLR9  
Affinity Capture-MS Homo sapiens
86 HM13 81502
Affinity Capture-MS Homo sapiens
87 SPPL2B 56928
Affinity Capture-MS Homo sapiens
88 GPR37L1  
Two-hybrid Homo sapiens
89 STT3B 201595
Affinity Capture-MS Homo sapiens
90 CLPTM1L 81037
Affinity Capture-MS Homo sapiens
91 VIPR1  
Affinity Capture-MS Homo sapiens
92 ADGRE5 976
Affinity Capture-MS Homo sapiens
93 HTR1B  
Affinity Capture-MS Homo sapiens
94 OR1D4  
Affinity Capture-MS Homo sapiens
95 SCAMP3 10067
Affinity Capture-MS Homo sapiens
96 FPR2  
Affinity Capture-MS Homo sapiens
97 OPALIN  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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