Gene description for LIME1
Gene name Lck interacting transmembrane adaptor 1
Gene symbol LIME1
Other names/aliases LIME
dJ583P15.4
Species Homo sapiens
 Database cross references - LIME1
ExoCarta ExoCarta_54923
Vesiclepedia VP_54923
Entrez Gene 54923
HGNC 26016
MIM 609809
UniProt Q9H400  
 LIME1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for LIME1
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
Biological Process
    adaptive immune response GO:0002250 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    regulation of canonical NF-kappaB signal transduction GO:0043122 IEA
    T cell receptor signaling pathway GO:0050852 IEA
    B cell receptor signaling pathway GO:0050853 IBA
    regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IEA
    regulation of non-canonical NF-kappaB signal transduction GO:1901222 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    B cell receptor complex GO:0019815 IBA
 Experiment description of studies that identified LIME1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LIME1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPY19L1 23333
Affinity Capture-MS Homo sapiens
2 UPK2 7379
Two-hybrid Homo sapiens
3 HSPA6 3310
Affinity Capture-MS Homo sapiens
4 TRAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PKMYT1  
Two-hybrid Homo sapiens
6 PPP3R1 5534
Affinity Capture-MS Homo sapiens
7 TMBIM6 7009
Two-hybrid Homo sapiens
8 GRB2 2885
Reconstituted Complex Homo sapiens
9 TMEM143  
Two-hybrid Homo sapiens
10 TMEM243  
Two-hybrid Homo sapiens
11 MEST 4232
Two-hybrid Homo sapiens
12 ZFPL1 7542
Two-hybrid Homo sapiens
13 HPCAL1 3241
Affinity Capture-MS Homo sapiens
14 FAM96A  
Two-hybrid Homo sapiens
15 AQP1 358
Two-hybrid Homo sapiens
16 ARFGAP3 26286
Two-hybrid Homo sapiens
17 IDE 3416
Affinity Capture-MS Homo sapiens
18 NINJ1 4814
Two-hybrid Homo sapiens
19 PTPN9 5780
Two-hybrid Homo sapiens
20 RTP2  
Two-hybrid Homo sapiens
21 AIG1  
Two-hybrid Homo sapiens
22 EMD 2010
Two-hybrid Homo sapiens
23 UNC93B1 81622
Two-hybrid Homo sapiens
24 GOSR2 9570
Two-hybrid Homo sapiens
25 HSPA8 3312
Affinity Capture-MS Homo sapiens
26 ZYG11B  
Affinity Capture-MS Homo sapiens
27 TMEM74  
Two-hybrid Homo sapiens
28 PBX3  
Two-hybrid Homo sapiens
29 HSPA1B 3304
Affinity Capture-MS Homo sapiens
30 SNAP47 116841
Two-hybrid Homo sapiens
31 FRMD8 83786
Two-hybrid Homo sapiens
32 TMEM86B  
Two-hybrid Homo sapiens
33 AGR3 155465
Two-hybrid Homo sapiens
34 NDRG4 65009
Two-hybrid Homo sapiens
35 NAPA 8775
Affinity Capture-MS Homo sapiens
36 TBRG4 9238
Two-hybrid Homo sapiens
37 MIEF2  
Two-hybrid Homo sapiens
38 HSPA2 3306
Affinity Capture-MS Homo sapiens
39 SLC41A2 84102
Two-hybrid Homo sapiens
40 BNIP2  
Two-hybrid Homo sapiens
41 EGFL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CALN1  
Two-hybrid Homo sapiens
43 PNPO 55163
Two-hybrid Homo sapiens
44 GAD2  
Two-hybrid Homo sapiens
45 C14orf180  
Two-hybrid Homo sapiens
46 HSPA9 3313
Affinity Capture-MS Homo sapiens
47 LHFPL5  
Two-hybrid Homo sapiens
48 GPX1 2876
Affinity Capture-MS Homo sapiens
49 LPAR3  
Two-hybrid Homo sapiens
50 TMEM97 27346
Two-hybrid Homo sapiens
51 STX6 10228
Two-hybrid Homo sapiens
52 CLN6  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LIME1 is involved
No pathways found





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