Gene description for Trap1
Gene name TNF receptor-associated protein 1
Gene symbol Trap1
Other names/aliases 2410002K23Rik
HSP75
Species Mus musculus
 Database cross references - Trap1
ExoCarta ExoCarta_68015
Vesiclepedia VP_68015
Entrez Gene 68015
UniProt Q9CQN1  
 Trap1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trap1
Molecular Function
    RNA binding GO:0003723 ISS
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IEA
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 ISO
    protein kinase binding GO:0019901 ISS
    unfolded protein binding GO:0051082 IBA
    unfolded protein binding GO:0051082 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    protein folding GO:0006457 IBA
    protein folding GO:0006457 IEA
    translational attenuation GO:0009386 IEA
    translational attenuation GO:0009386 ISO
    negative regulation of cellular respiration GO:1901856 ISO
    negative regulation of cellular respiration GO:1901856 ISS
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:1903751 ISO
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:1903751 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrial intermembrane space GO:0005758 ISO
    mitochondrial intermembrane space GO:0005758 ISS
    mitochondrial matrix GO:0005759 ISO
    mitochondrial matrix GO:0005759 ISS
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Trap1 in sEVs
1
Experiment ID 15
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ogfr  
Co-fractionation Mus musculus
2 Nphp4  
Affinity Capture-MS Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Ext2  
Co-fractionation Mus musculus
5 Trap1 68015
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
6 Hspa9 15526
Cross-Linking-MS (XL-MS) Mus musculus
7 Atg16l1  
Affinity Capture-MS Mus musculus
8 Ext1 14042
Co-fractionation Mus musculus
9 Tlr1  
Co-fractionation Mus musculus
10 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Trap1 is involved
PathwayEvidenceSource
Aerobic respiration and respiratory electron transport IEA Reactome
Citric acid cycle (TCA cycle) IEA Reactome
Metabolism IEA Reactome





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