Gene description for PLA2G6
Gene name phospholipase A2, group VI (cytosolic, calcium-independent)
Gene symbol PLA2G6
Other names/aliases CaI-PLA2
GVI
INAD1
IPLA2-VIA
NBIA2
NBIA2A
NBIA2B
PARK14
PLA2
PNPLA9
iPLA2
iPLA2beta
Species Homo sapiens
 Database cross references - PLA2G6
ExoCarta ExoCarta_8398
Vesiclepedia VP_8398
Entrez Gene 8398
HGNC 9039
MIM 603604
UniProt O60733  
 PLA2G6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PLA2G6
Molecular Function
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 ISS
    lysophospholipase activity GO:0004622 IDA
    phospholipase A2 activity GO:0004623 TAS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    hydrolase activity GO:0016787 TAS
    serine hydrolase activity GO:0017171 IEA
    identical protein binding GO:0042802 IPI
    calcium-dependent phospholipase A2 activity GO:0047498 IEA
    calcium-independent phospholipase A2 activity GO:0047499 IBA
    calcium-independent phospholipase A2 activity GO:0047499 IDA
    long-chain fatty acyl-CoA hydrolase activity GO:0052816 IBA
    long-chain fatty acyl-CoA hydrolase activity GO:0052816 IDA
Biological Process
    chemotaxis GO:0006935 IEA
    antibacterial humoral response GO:0019731 IDA
    cardiolipin biosynthetic process GO:0032049 IMP
    phosphatidylcholine catabolic process GO:0034638 IDA
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 ISS
    cardiolipin acyl-chain remodeling GO:0035965 IBA
    cardiolipin acyl-chain remodeling GO:0035965 IDA
    cardiolipin acyl-chain remodeling GO:0035965 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    phosphatidylethanolamine catabolic process GO:0046338 ISS
    platelet activating factor metabolic process GO:0046469 ISS
    phosphatidic acid metabolic process GO:0046473 ISS
    positive regulation of ceramide biosynthetic process GO:2000304 IBA
Subcellular Localization
    extracellular space GO:0005615 IDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    microtubule cytoskeleton GO:0015630 IDA
    nuclear speck GO:0016607 IDA
    pseudopodium GO:0031143 IEA
 Experiment description of studies that identified PLA2G6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PLA2G6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHEK1  
Affinity Capture-MS Homo sapiens
2 TRIM50  
Two-hybrid Homo sapiens
3 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
4 HIF1AN 55662
Affinity Capture-MS Homo sapiens
5 FAM96A  
Affinity Capture-MS Homo sapiens
6 DHFR 1719
Affinity Capture-MS Homo sapiens
7 Arf1 11840
Affinity Capture-Western Mus musculus
8 RCBTB2  
Two-hybrid Homo sapiens
9 NUP93 9688
Two-hybrid Homo sapiens
10 PLA2G6 8398
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
11 ZBTB42  
Two-hybrid Homo sapiens
12 CEP76  
Two-hybrid Homo sapiens
13 USP54 159195
Two-hybrid Homo sapiens
14 CALM1 801
Reconstituted Complex Homo sapiens
15 RUSC1  
Two-hybrid Homo sapiens
16 SERTAD2 9792
Two-hybrid Homo sapiens
17 UBXN6 80700
Affinity Capture-MS Homo sapiens
18 DDX58 23586
Affinity Capture-RNA Homo sapiens
19 CCDC33 80125
Two-hybrid Homo sapiens
View the network image/svg+xml



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