Gene description for COX4I2
Gene name cytochrome c oxidase subunit IV isoform 2 (lung)
Gene symbol COX4I2
Other names/aliases COX4
COX4-2
COX4B
COX4L2
COXIV-2
dJ857M17.2
Species Homo sapiens
 Database cross references - COX4I2
ExoCarta ExoCarta_84701
Vesiclepedia VP_84701
Entrez Gene 84701
HGNC 16232
MIM 607976
UniProt Q96KJ9  
 COX4I2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX4I2
Molecular Function
    cytochrome-c oxidase activity GO:0004129 IDA
Biological Process
    generation of precursor metabolites and energy GO:0006091 NAS
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IBA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IDA
    cellular respiration GO:0045333 NAS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial intermembrane space GO:0005758 TAS
    respiratory chain complex IV GO:0045277 IBA
    respiratory chain complex IV GO:0045277 IC
 Experiment description of studies that identified COX4I2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX4I2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 PIGA  
Affinity Capture-MS Homo sapiens
3 MTHFR 4524
Affinity Capture-MS Homo sapiens
4 UQCRB 7381
Affinity Capture-MS Homo sapiens
5 KDM8  
Affinity Capture-MS Homo sapiens
6 COA3 28958
Affinity Capture-Western Homo sapiens
7 FAM209A 200232
Affinity Capture-MS Homo sapiens
8 CYCS 54205
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
9 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
10 COX5A 9377
Affinity Capture-MS Homo sapiens
11 COX1 4512
Affinity Capture-MS Homo sapiens
12 COX6A1  
Affinity Capture-MS Homo sapiens
13 UQCRQ 27089
Affinity Capture-MS Homo sapiens
14 COX7A2L 9167
Affinity Capture-MS Homo sapiens
15 COX6C 1345
Affinity Capture-MS Homo sapiens
16 RSPRY1 89970
Affinity Capture-MS Homo sapiens
17 SACM1L 22908
Affinity Capture-MS Homo sapiens
18 ATP1A3 478
Affinity Capture-MS Homo sapiens
19 COX6B1 1340
Affinity Capture-MS Homo sapiens
20 TRPC4AP  
Affinity Capture-MS Homo sapiens
21 LRRC41 10489
Affinity Capture-MS Homo sapiens
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