Gene description for COX5A
Gene name cytochrome c oxidase subunit Va
Gene symbol COX5A
Other names/aliases COX
COX-VA
VA
Species Homo sapiens
 Database cross references - COX5A
ExoCarta ExoCarta_9377
Vesiclepedia VP_9377
Entrez Gene 9377
HGNC 2267
MIM 603773
UniProt P20674  
 COX5A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
 Gene ontology annotations for COX5A
Molecular Function
    cytochrome-c oxidase activity GO:0004129 TAS
    protein binding GO:0005515 IPI
    electron transfer activity GO:0009055 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IBA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 NAS
    cellular respiration GO:0045333 NAS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial intermembrane space GO:0005758 TAS
    mitochondrial membrane GO:0031966 IDA
    respiratory chain complex IV GO:0045277 IBA
    respiratory chain complex IV GO:0045277 IDA
    respiratory chain complex IV GO:0045277 IMP
 Experiment description of studies that identified COX5A in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for COX5A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Co-fractionation Homo sapiens
2 CLIP1 6249
Affinity Capture-MS Homo sapiens
3 GUK1 2987
Co-fractionation Homo sapiens
4 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
5 PSMD11 5717
Co-fractionation Homo sapiens
6 COPS6 10980
Two-hybrid Homo sapiens
7 LAP3 51056
Co-fractionation Homo sapiens
8 TRUB2  
Proximity Label-MS Homo sapiens
9 MTG2  
Proximity Label-MS Homo sapiens
10 BRD2  
Affinity Capture-MS Homo sapiens
11 Htt  
Affinity Capture-MS Mus musculus
12 NDUFA4 4697
Affinity Capture-MS Homo sapiens
13 COX8A  
Co-fractionation Homo sapiens
14 CCDC90B  
Proximity Label-MS Homo sapiens
15 HSPA5 3309
Co-fractionation Homo sapiens
16 LRPPRC 10128
Proximity Label-MS Homo sapiens
17 KIAA1429 25962
Affinity Capture-MS Homo sapiens
18 NDUFB9 4715
Co-fractionation Homo sapiens
19 ATP5D 513
Co-fractionation Homo sapiens
20 HEATR3 55027
Affinity Capture-MS Homo sapiens
21 NDUFS3 4722
Co-fractionation Homo sapiens
22 OGDH 4967
Co-fractionation Homo sapiens
23 HADHA 3030
Co-fractionation Homo sapiens
24 KIF22  
Affinity Capture-MS Homo sapiens
25 PMPCA 23203
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
26 COQ9  
Affinity Capture-MS Homo sapiens
27 KRT40  
Two-hybrid Homo sapiens
28 COX7A2L 9167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PTPMT1 114971
Affinity Capture-MS Homo sapiens
30 CHCHD2  
Affinity Capture-MS Homo sapiens
31 PPP3CB  
Affinity Capture-MS Homo sapiens
32 PRC1 9055
Affinity Capture-MS Homo sapiens
33 HINT2 84681
Proximity Label-MS Homo sapiens
34 CHCHD10  
Affinity Capture-MS Homo sapiens
35 SLC25A12 8604
Proximity Label-MS Homo sapiens
36 SLC9A9 285195
Affinity Capture-MS Homo sapiens
37 COA3 28958
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
38 RER1 11079
Affinity Capture-MS Homo sapiens
39 Cenpe  
Affinity Capture-MS Mus musculus
40 KRT31 3881
Two-hybrid Homo sapiens
41 ATP5O 539
Co-fractionation Homo sapiens
42 SPDEF  
Two-hybrid Homo sapiens
43 EXD2  
Proximity Label-MS Homo sapiens
44 NDUFV1 4723
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
45 PHB 5245
Co-fractionation Homo sapiens
46 ATP5H 10476
Co-fractionation Homo sapiens
47 SLC30A9 10463
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KLF16  
Affinity Capture-MS Homo sapiens
49 PMPCB 9512
Proximity Label-MS Homo sapiens
50 TACO1  
Proximity Label-MS Homo sapiens
51 COX1 4512
Affinity Capture-MS Homo sapiens
52 DAP3 7818
Co-fractionation Homo sapiens
53 MTERF3  
Proximity Label-MS Homo sapiens
54 NDUFB10 4716
Co-fractionation Homo sapiens
55 KIF14 9928
Affinity Capture-MS Homo sapiens
56 PRNP 5621
Affinity Capture-MS Homo sapiens
57 FXN  
Co-fractionation Homo sapiens
58 MDH2 4191
Proximity Label-MS Homo sapiens
59 UNK  
Affinity Capture-RNA Homo sapiens
60 APOO 79135
Proximity Label-MS Homo sapiens
61 AURKA 6790
Affinity Capture-MS Homo sapiens
62 ATP5A1 498
Co-fractionation Homo sapiens
63 HNRNPA0 10949
Co-fractionation Homo sapiens
64 COX15 1355
Proximity Label-MS Homo sapiens
65 MRPS26 64949
Proximity Label-MS Homo sapiens
66 C20orf24  
Co-fractionation Homo sapiens
67 SURF1  
Proximity Label-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
69 HSP90B1 7184
Co-fractionation Homo sapiens
70 NONO 4841
Co-fractionation Homo sapiens
71 TUFM 7284
Proximity Label-MS Homo sapiens
72 DIABLO 56616
Proximity Label-MS Homo sapiens
73 ACACA 31
Affinity Capture-MS Homo sapiens
74 HSCB 150274
Proximity Label-MS Homo sapiens
75 TIMM9  
Co-fractionation Homo sapiens
76 CYB5A 1528
Co-fractionation Homo sapiens
77 PMAIP1  
Affinity Capture-MS Homo sapiens
78 Rhoa 11848
Affinity Capture-MS Mus musculus
79 CCDC109B 55013
Proximity Label-MS Homo sapiens
80 OPA1 4976
Proximity Label-MS Homo sapiens
81 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
82 CYC1 1537
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
83 ACTB 60
Co-fractionation Homo sapiens
84 MCU 90550
Proximity Label-MS Homo sapiens
85 MRPL11 65003
Proximity Label-MS Homo sapiens
86 MTRF1L  
Proximity Label-MS Homo sapiens
87 DNAJC30  
Proximity Label-MS Homo sapiens
88 TFAM 7019
Co-fractionation Homo sapiens
89 CLIC4 25932
Co-fractionation Homo sapiens
90 TMEM70  
Proximity Label-MS Homo sapiens
91 NIPSNAP1 8508
Co-fractionation Homo sapiens
92 ATP5B 506
Co-fractionation Homo sapiens
93 COX4I1 1327
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 MESDC2 23184
Two-hybrid Homo sapiens
95 TXN2 25828
Co-fractionation Homo sapiens
96 CISD3 284106
Affinity Capture-MS Homo sapiens
97 C15orf48  
Affinity Capture-MS Homo sapiens
98 SFPQ 6421
Co-fractionation Homo sapiens
99 ZBTB2 57621
Affinity Capture-MS Homo sapiens
100 COX5B 1329
Co-fractionation Homo sapiens
101 HADHB 3032
Co-fractionation Homo sapiens
102 MRRF  
Proximity Label-MS Homo sapiens
103 BLVRB 645
Affinity Capture-MS Homo sapiens
104 METTL14  
Affinity Capture-MS Homo sapiens
105 MTIF2 4528
Proximity Label-MS Homo sapiens
106 DOCK8 81704
Affinity Capture-MS Homo sapiens
107 ATP5F1 515
Co-fractionation Homo sapiens
108 LMNB1 4001
Affinity Capture-MS Homo sapiens
109 CLPP 8192
Proximity Label-MS Homo sapiens
110 NELFCD 51497
Affinity Capture-MS Homo sapiens
111 UQCRC2 7385
Co-fractionation Homo sapiens
112 UQCRB 7381
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
113 GOLT1B 51026
Affinity Capture-MS Homo sapiens
114 BCAP31 10134
Co-fractionation Homo sapiens
115 ASS1 445
Affinity Capture-MS Homo sapiens
116 NR3C1 2908
Proximity Label-MS Homo sapiens
117 RMND1 55005
Proximity Label-MS Homo sapiens
118 NUP43 348995
Proximity Label-MS Homo sapiens
119 COX6B1 1340
Co-fractionation Homo sapiens
120 OCIAD1 54940
Proximity Label-MS Homo sapiens
121 AURKB 9212
Affinity Capture-MS Homo sapiens
122 C12orf65  
Proximity Label-MS Homo sapiens
123 MYCN  
Affinity Capture-MS Homo sapiens
124 FKBP5 2289
Affinity Capture-MS Homo sapiens
125 TPM1 7168
Co-fractionation Homo sapiens
126 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
127 MYC  
Affinity Capture-MS Homo sapiens
128 EPM2A  
Two-hybrid Homo sapiens
129 COX6C 1345
Co-fractionation Homo sapiens
130 ATP1B3 483
Affinity Capture-MS Homo sapiens
131 TSFM 10102
Proximity Label-MS Homo sapiens
132 GSTK1 373156
Co-fractionation Homo sapiens
133 ACAD9 28976
Proximity Label-MS Homo sapiens
134 VDAC1 7416
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 TBCA 6902
Co-fractionation Homo sapiens
136 COX2 4513
Co-fractionation Homo sapiens
137 HSPA9 3313
Co-fractionation Homo sapiens
138 TPM4 7171
Co-fractionation Homo sapiens
139 MCUR1 63933
Proximity Label-MS Homo sapiens
140 SCCPDH 51097
Co-fractionation Homo sapiens
141 MTRF1  
Proximity Label-MS Homo sapiens
142 PHGDH 26227
Affinity Capture-MS Homo sapiens
143 TPM3 7170
Co-fractionation Homo sapiens
144 GBAS 2631
Co-fractionation Homo sapiens
145 DUSP19  
Affinity Capture-MS Homo sapiens
146 DNAJC4  
Proximity Label-MS Homo sapiens
147 YBX1 4904
Co-fractionation Homo sapiens
148 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
149 C17orf80 55028
Proximity Label-MS Homo sapiens
150 PHB2 11331
Co-fractionation Homo sapiens
151 SLC38A2 54407
Co-fractionation Homo sapiens
152 METTL17  
Proximity Label-MS Homo sapiens
153 AUH 549
Proximity Label-MS Homo sapiens
154 ATP5J 522
Affinity Capture-MS Homo sapiens
155 COX4I2 84701
Affinity Capture-MS Homo sapiens
156 KDM1B  
Affinity Capture-MS Homo sapiens
157 LONP1 9361
Proximity Label-MS Homo sapiens
158 BCKDHA 593
Co-fractionation Homo sapiens
159 PDHA1 5160
Co-fractionation Homo sapiens
160 DNAJA3 9093
Proximity Label-MS Homo sapiens
161 Arhgap30  
Affinity Capture-MS Mus musculus
162 G3BP1 10146
Affinity Capture-MS Homo sapiens
163 FKBP9 11328
Co-fractionation Homo sapiens
164 PDHB 5162
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
165 OPA3 80207
Affinity Capture-MS Homo sapiens
166 NUP35 129401
Proximity Label-MS Homo sapiens
167 C21orf33  
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
168 SSBP1 6742
Proximity Label-MS Homo sapiens
169 RAB8A 4218
Co-fractionation Homo sapiens
170 PAF1 54623
Affinity Capture-MS Homo sapiens
171 TBRG4 9238
Proximity Label-MS Homo sapiens
172 TEFM  
Proximity Label-MS Homo sapiens
173 YBX3 8531
Co-fractionation Homo sapiens
174 C19orf52  
Proximity Label-MS Homo sapiens
175 SLC25A51  
Proximity Label-MS Homo sapiens
176 FERMT3 83706
Affinity Capture-MS Homo sapiens
177 C1QBP 708
Proximity Label-MS Homo sapiens
178 CUL7 9820
Affinity Capture-MS Homo sapiens
179 ATP5C1 509
Co-fractionation Homo sapiens
180 COX7C 1350
Co-fractionation Homo sapiens
181 RAC1 5879
Affinity Capture-MS Homo sapiens
182 VDAC3 7419
Co-fractionation Homo sapiens
183 NEMF 9147
Co-fractionation Homo sapiens
184 MGST3 4259
Co-fractionation Homo sapiens
185 EXOSC8  
Two-hybrid Homo sapiens
186 MTCH2 23788
Co-fractionation Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here