Gene description for HPDL
Gene name 4-hydroxyphenylpyruvate dioxygenase-like
Gene symbol HPDL
Other names/aliases 4-HPPD-L
GLOXD1
Species Homo sapiens
 Database cross references - HPDL
ExoCarta ExoCarta_84842
Vesiclepedia VP_84842
Entrez Gene 84842
HGNC 28242
UniProt Q96IR7  
 HPDL identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for HPDL
Molecular Function
    4-hydroxyphenylpyruvate dioxygenase activity GO:0003868 IEA
    metal ion binding GO:0046872 IEA
    4-hydroxymandelate synthase activity GO:0050585 IMP
Biological Process
    aromatic amino acid metabolic process GO:0009072 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified HPDL in sEVs
1
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HPDL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STMN1 3925
Co-fractionation Homo sapiens
2 M6PR 4074
Co-fractionation Homo sapiens
3 RIF1  
Co-fractionation Homo sapiens
4 TACO1  
Co-fractionation Homo sapiens
5 EPHX1 2052
Co-fractionation Homo sapiens
6 MECP2 4204
Co-fractionation Homo sapiens
7 UBC 7316
Reconstituted Complex Homo sapiens
8 TMEM177  
Co-fractionation Homo sapiens
9 HTRA2 27429
Co-fractionation Homo sapiens
10 TST 7263
Co-fractionation Homo sapiens
11 SUCLA2 8803
Co-fractionation Homo sapiens
12 LSM12 124801
Co-fractionation Homo sapiens
13 TOR1AIP1 26092
Co-fractionation Homo sapiens
14 NUSAP1 51203
Co-fractionation Homo sapiens
15 TCOF1 6949
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which HPDL is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of cofactors TAS Reactome
Metabolism of vitamins and cofactors TAS Reactome
Ubiquinol biosynthesis TAS Reactome





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