Gene description for LSM12
Gene name LSM12 homolog (S. cerevisiae)
Gene symbol LSM12
Other names/aliases PNAS-135
Species Homo sapiens
 Database cross references - LSM12
ExoCarta ExoCarta_124801
Vesiclepedia VP_124801
Entrez Gene 124801
HGNC 26407
MIM 611793
UniProt Q3MHD2  
 LSM12 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for LSM12
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
Subcellular Localization
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified LSM12 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LSM12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LSM2 57819
Two-hybrid Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 DDX6 1656
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 EDC3 80153
Affinity Capture-MS Homo sapiens
6 EIF3G 8666
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 SIRT6  
Affinity Capture-MS Homo sapiens
10 ARHGEF10L 55160
Affinity Capture-MS Homo sapiens
11 PABPC4 8761
Affinity Capture-MS Homo sapiens
12 DCP1B  
Affinity Capture-MS Homo sapiens
13 HSPA8 3312
Affinity Capture-MS Homo sapiens
14 FAS 355
Proximity Label-MS Homo sapiens
15 ATXN2 6311
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 UTP11L  
Affinity Capture-MS Homo sapiens
17 OCRL 4952
Affinity Capture-MS Homo sapiens
18 TARDBP 23435
Affinity Capture-MS Homo sapiens
19 DSTYK 25778
Affinity Capture-MS Homo sapiens
20 BTF3 689
Affinity Capture-MS Homo sapiens
21 NF2 4771
Affinity Capture-MS Homo sapiens
22 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
23 NUFIP2 57532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 LSM14A 26065
Affinity Capture-MS Homo sapiens
25 SOX2  
Affinity Capture-MS Homo sapiens
26 PDHA1 5160
Affinity Capture-MS Homo sapiens
27 CUL3 8452
Affinity Capture-MS Homo sapiens
28 SLC9A3R2 9351
Co-fractionation Homo sapiens
29 UBC 7316
Affinity Capture-MS Homo sapiens
30 EGFR 1956
Negative Genetic Homo sapiens
31 RCCD1  
Affinity Capture-MS Homo sapiens
32 SH3RF2  
Affinity Capture-MS Homo sapiens
33 EDC4 23644
Affinity Capture-MS Homo sapiens
34 NID2 22795
Affinity Capture-MS Homo sapiens
35 FUS 2521
Affinity Capture-MS Homo sapiens
36 DNMBP 23268
Affinity Capture-MS Homo sapiens
37 FAM195B 348262
Affinity Capture-MS Homo sapiens
38 FAM195A  
Affinity Capture-MS Homo sapiens
39 HPDL 84842
Co-fractionation Homo sapiens
40 FN1 2335
Affinity Capture-MS Homo sapiens
41 RRP36 88745
Affinity Capture-MS Homo sapiens
42 CAND1 55832
Affinity Capture-MS Homo sapiens
43 KIAA1429 25962
Affinity Capture-MS Homo sapiens
44 CAPZB 832
Affinity Capture-MS Homo sapiens
45 RPS20 6224
Proximity Label-MS Homo sapiens
46 E2F4  
Affinity Capture-MS Homo sapiens
47 PCBP1 5093
Co-fractionation Homo sapiens
48 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
49 API5 8539
Affinity Capture-MS Homo sapiens
50 B3GNT2 10678
Affinity Capture-MS Homo sapiens
51 PSPC1 55269
Affinity Capture-MS Homo sapiens
52 AURKA 6790
Affinity Capture-MS Homo sapiens
53 LSM3 27258
Two-hybrid Homo sapiens
54 WDYHV1  
Two-hybrid Homo sapiens
55 G3BP2 9908
Affinity Capture-MS Homo sapiens
56 C9orf72  
Affinity Capture-MS Homo sapiens
57 PCYT1A 5130
Affinity Capture-MS Homo sapiens
58 ATXN2L 11273
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 AAMDC  
Affinity Capture-MS Homo sapiens
60 DCP1A 55802
Affinity Capture-MS Homo sapiens
61 COPS5 10987
Affinity Capture-MS Homo sapiens
62 BICD2 23299
Proximity Label-MS Homo sapiens
63 HMGCL 3155
Co-fractionation Homo sapiens
64 MDC1  
Affinity Capture-MS Homo sapiens
65 GNB2L1 10399
Co-fractionation Homo sapiens
66 KCTD21 283219
Affinity Capture-MS Homo sapiens
67 MYC  
Affinity Capture-MS Homo sapiens
68 ATXN3 4287
Affinity Capture-MS Homo sapiens
69 NDC80 10403
Affinity Capture-MS Homo sapiens
70 HIBCH 26275
Co-fractionation Homo sapiens
71 PRMT1 3276
Affinity Capture-MS Homo sapiens
72 CEBPA  
Protein-peptide Homo sapiens
73 HUWE1 10075
Affinity Capture-MS Homo sapiens
74 CASC3  
Affinity Capture-MS Homo sapiens
75 RPS16 6217
Affinity Capture-MS Homo sapiens
76 SP100 6672
Affinity Capture-MS Homo sapiens
77 GSR 2936
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which LSM12 is involved
No pathways found





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