Gene description for KCNAB2
Gene name potassium channel, voltage gated subfamily A regulatory beta subunit 2
Gene symbol KCNAB2
Other names/aliases AKR6A5
HKvbeta2
HKvbeta2.1
HKvbeta2.2
KCNA2B
KV-BETA-2
Species Homo sapiens
 Database cross references - KCNAB2
ExoCarta ExoCarta_8514
Vesiclepedia VP_8514
Entrez Gene 8514
HGNC 6229
MIM 601142
UniProt Q13303  
 KCNAB2 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for KCNAB2
Molecular Function
    aldo-keto reductase (NADPH) activity GO:0004033 IBA
    aldo-keto reductase (NADPH) activity GO:0004033 ISS
    voltage-gated potassium channel activity GO:0005249 IEA
    protein binding GO:0005515 IPI
    potassium channel regulator activity GO:0015459 IBA
    potassium channel regulator activity GO:0015459 IDA
    transmembrane transporter binding GO:0044325 IBA
    methylglyoxal reductase (NADPH) (acetol producing) activity GO:1990002 IEA
Biological Process
    NADPH oxidation GO:0070995 ISS
    potassium ion transmembrane transport GO:0071805 IEA
    regulation of potassium ion transmembrane transport GO:1901379 IBA
    regulation of potassium ion transmembrane transport GO:1901379 IDA
    regulation of protein localization to cell surface GO:2000008 ISS
Subcellular Localization
    cytosol GO:0005829 ISS
    microtubule GO:0005874 ISS
    plasma membrane GO:0005886 TAS
    voltage-gated potassium channel complex GO:0008076 IBA
    voltage-gated potassium channel complex GO:0008076 IDA
    cytoplasmic side of plasma membrane GO:0009898 ISS
    membrane GO:0016020 IDA
    specific granule membrane GO:0035579 TAS
    juxtaparanode region of axon GO:0044224 IBA
    juxtaparanode region of axon GO:0044224 IDA
    juxtaparanode region of axon GO:0044224 ISS
    synapse GO:0045202 IEA
    tertiary granule membrane GO:0070821 TAS
    pinceau fiber GO:1990031 ISS
 Experiment description of studies that identified KCNAB2 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KCNAB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATXN1 6310
Two-hybrid Homo sapiens
2 SNX3 8724
Affinity Capture-MS Homo sapiens
3 NUTF2 10204
Co-fractionation Homo sapiens
4 KCNA2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
5 NEDD4 4734
Reconstituted Complex Homo sapiens
6 PREP 5550
Co-fractionation Homo sapiens
7 NASP 4678
Affinity Capture-MS Homo sapiens
8 KCNAB2 8514
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 DDX58 23586
Affinity Capture-RNA Homo sapiens
10 BCOR  
Affinity Capture-MS Homo sapiens
11 Rab5b 19344
Affinity Capture-MS Mus musculus
12 Dync1li1 235661
Affinity Capture-MS Mus musculus
13 RPA2 6118
Affinity Capture-MS Homo sapiens
14 RPA1 6117
Affinity Capture-MS Homo sapiens
15 MFAP4 4239
Affinity Capture-MS Homo sapiens
16 HAO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MRPL50 54534
Affinity Capture-MS Homo sapiens
18 KCNAB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CCAR2 57805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ZNF281  
Affinity Capture-MS Homo sapiens
21 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 KCNA3  
Co-crystal Structure Homo sapiens
23 BAG6 7917
Affinity Capture-MS Homo sapiens
24 RPA3 6119
Affinity Capture-MS Homo sapiens
25 KCNA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 Nedd4 25489
Reconstituted Complex Rattus norvegicus
27 GAPVD1 26130
Affinity Capture-MS Homo sapiens
28 KCNA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 Snw1  
Affinity Capture-MS Mus musculus
30 TNNC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 KCNA5  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 Gbf1  
Affinity Capture-MS Mus musculus
33 PEX19 5824
Affinity Capture-MS Homo sapiens
34 GRIA2  
Affinity Capture-MS Homo sapiens
35 CEBPA  
Protein-peptide Homo sapiens
36 NEDD4L 23327
Reconstituted Complex Homo sapiens
37 ALDOA 226
Co-fractionation Homo sapiens
38 ATIC 471
Co-fractionation Homo sapiens
39 Ubr5  
Affinity Capture-MS Mus musculus
40 KCNAB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 KCNA4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
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