Gene description for MAPKAPK5
Gene name	mitogen-activated protein kinase-activated protein kinase 5
Gene symbol	MAPKAPK5
Other names/aliases	MAPKAP-K5 MK-5 MK5 PRAK
Species	Homo sapiens
Database cross references - MAPKAPK5
ExoCarta	ExoCarta_8550
Vesiclepedia	VP_8550
Entrez Gene	8550
HGNC	6889
MIM	606723
UniProt	Q8IW41
MAPKAPK5 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for MAPKAPK5

Molecular Function     p53 binding GO:0002039 IDA     protein serine/threonine kinase activity GO:0004674 EXP     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 TAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     MAP kinase kinase activity GO:0004708 TAS     ribosomal protein S6 kinase activity GO:0004711 IEA     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IBA     ATP binding GO:0005524 IEA     calcium-dependent protein serine/threonine kinase activity GO:0009931 IBA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     mitogen-activated protein kinase binding GO:0051019 IBA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     MAPK cascade GO:0000165 IEA     chromatin remodeling GO:0006338 IEA     regulation of translation GO:0006417 IDA     signal transduction GO:0007165 TAS     Ras protein signal transduction GO:0007265 IBA     Ras protein signal transduction GO:0007265 IDA     negative regulation of TOR signaling GO:0032007 IBA     negative regulation of TOR signaling GO:0032007 ISS     positive regulation of telomere maintenance GO:0032206 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     protein autophosphorylation GO:0046777 IDA     positive regulation of dendritic spine development GO:0060999 IEA     cellular senescence GO:0090398 TAS     stress-induced premature senescence GO:0090400 IDA     regulation of signal transduction by p53 class mediator GO:1901796 TAS Subcellular Localization     nucleus GO:0005634 IBA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     septin cytoskeleton GO:0032156 IEA     protein-containing complex GO:0032991 IEA