Gene description for LIPG
Gene name lipase, endothelial
Gene symbol LIPG
Other names/aliases EDL
EL
PRO719
Species Homo sapiens
 Database cross references - LIPG
ExoCarta ExoCarta_9388
Vesiclepedia VP_9388
Entrez Gene 9388
HGNC 6623
MIM 603684
UniProt Q9Y5X9  
 LIPG identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for LIPG
Molecular Function
    lipoprotein lipase activity GO:0004465 IBA
    phospholipase activity GO:0004620 IDA
    triacylglycerol lipase activity GO:0004806 IDA
    heparin binding GO:0008201 IEA
    phospholipase A1 activity GO:0008970 IBA
    phospholipase A1 activity GO:0008970 IDA
    phosphatidylserine 1-acylhydrolase activity GO:0052739 IEA
Biological Process
    lipid metabolic process GO:0006629 TAS
    fatty acid biosynthetic process GO:0006633 IBA
    response to nutrient GO:0007584 IEA
    phospholipid catabolic process GO:0009395 NAS
    positive regulation of high-density lipoprotein particle clearance GO:0010983 IMP
    triglyceride catabolic process GO:0019433 IBA
    positive regulation of cholesterol transport GO:0032376 IDA
    high-density lipoprotein particle remodeling GO:0034375 IBA
    high-density lipoprotein particle remodeling GO:0034375 IMP
    cholesterol homeostasis GO:0042632 IBA
    cholesterol homeostasis GO:0042632 IMP
    reverse cholesterol transport GO:0043691 IMP
    regulation of lipoprotein metabolic process GO:0050746 IEA
    phospholipid homeostasis GO:0055091 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    early endosome GO:0005769 IDA
    Golgi apparatus GO:0005794 IDA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified LIPG in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for LIPG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRMT1 55621
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 NOMO1 23420
Affinity Capture-MS Homo sapiens
3 TOR3A 64222
Affinity Capture-MS Homo sapiens
4 NRP1 8829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 HS3ST1  
Affinity Capture-MS Homo sapiens
6 PLS1 5357
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TMED10 10972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NAAA  
Affinity Capture-MS Homo sapiens
9 EDEM2  
Affinity Capture-MS Homo sapiens
10 TMED9 54732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 P3H4 10609
Affinity Capture-MS Homo sapiens
12 LOXL2 4017
Affinity Capture-MS Homo sapiens
13 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MAN2B2 23324
Affinity Capture-MS Homo sapiens
15 CHST12 55501
Affinity Capture-MS Homo sapiens
16 PDIA4 9601
Affinity Capture-MS Homo sapiens
17 TMED4 222068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TMED5 50999
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 P4HTM  
Affinity Capture-MS Homo sapiens
20 Lipg  
Affinity Capture-Western Mus musculus
21 METRNL 284207
Affinity Capture-MS Homo sapiens
22 HSPA13 6782
Affinity Capture-MS Homo sapiens
23 ARL8A 127829
Affinity Capture-MS Homo sapiens
24 ERLEC1 27248
Affinity Capture-MS Homo sapiens
25 TOR1B 27348
Affinity Capture-MS Homo sapiens
26 ITIH2 3698
Affinity Capture-MS Homo sapiens
27 ETNPPL  
Affinity Capture-MS Homo sapiens
28 CLSTN1 22883
Affinity Capture-MS Homo sapiens
29 TUBB1 81027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SDC2 6383
Affinity Capture-MS Homo sapiens
31 FGFR3 2261
Affinity Capture-MS Homo sapiens
32 GPX8 493869
Affinity Capture-MS Homo sapiens
33 FANCA  
Two-hybrid Homo sapiens
34 UXS1 80146
Affinity Capture-MS Homo sapiens
35 GALNT18  
Affinity Capture-MS Homo sapiens
36 ARSG 22901
Affinity Capture-MS Homo sapiens
37 PTPRS 5802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 LRP5 4041
Affinity Capture-MS Homo sapiens
39 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
40 HYAL2 8692
Affinity Capture-MS Homo sapiens
41 ADGRG1 9289
Affinity Capture-MS Homo sapiens
42 LAMB2 3913
Affinity Capture-MS Homo sapiens
43 GPC3 2719
Affinity Capture-MS Homo sapiens
44 EXOSC5 56915
Two-hybrid Homo sapiens
45 DGCR2 9993
Affinity Capture-MS Homo sapiens
46 JAG2  
Affinity Capture-MS Homo sapiens
47 LDLR 3949
Affinity Capture-MS Homo sapiens
48 TMED2 10959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 P3H3 10536
Affinity Capture-MS Homo sapiens
50 SUMF1 285362
Affinity Capture-MS Homo sapiens
51 FGFR4 2264
Affinity Capture-MS Homo sapiens
52 MFI2 4241
Affinity Capture-MS Homo sapiens
53 MAPK14 1432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 POGLUT1 56983
Affinity Capture-MS Homo sapiens
55 ABHD14A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ARSK  
Affinity Capture-MS Homo sapiens
57 NMU  
Affinity Capture-MS Homo sapiens
58 BMP4 652
Affinity Capture-MS Homo sapiens
59 DNAJC13 23317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SUN2 25777
Affinity Capture-MS Homo sapiens
61 TMED1 11018
Affinity Capture-MS Homo sapiens
62 CERCAM 51148
Affinity Capture-MS Homo sapiens
63 HLA-C 3107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 LIPG 9388
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here