Gene description for CHMP4BP1
Gene name charged multivesicular body protein 4B pseudogene 1
Gene symbol CHMP4BP1
Other names/aliases -
Species Homo sapiens
 Database cross references - CHMP4BP1
ExoCarta ExoCarta_100307126
Vesiclepedia VP_100307126
Entrez Gene 100307126
HGNC 43616
 CHMP4BP1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CHMP4BP1
Biological Process
    plasma membrane repair GO:0001778 IEA
    vesicle budding from membrane GO:0006900 IBA
    mitotic metaphase chromosome alignment GO:0007080 IEA
    nuclear membrane reassembly GO:0031468 IEA
    late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511 IBA
    viral budding via host ESCRT complex GO:0039702 IEA
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IEA
    viral budding from plasma membrane GO:0046761 IEA
    midbody abscission GO:0061952 IEA
    autophagosome maturation GO:0097352 IEA
    regulation of mitotic spindle assembly GO:1901673 IEA
    late endosome to lysosome transport GO:1902774 IEA
Subcellular Localization
    kinetochore GO:0000776 IEA
    ESCRT III complex GO:0000815 IBA
    nuclear pore GO:0005643 IEA
    lysosomal membrane GO:0005765 IEA
    multivesicular body GO:0005771 IBA
    kinetochore microtubule GO:0005828 IEA
    cytoplasmic side of plasma membrane GO:0009898 IBA
    midbody GO:0030496 IEA
    multivesicular body membrane GO:0032585 IEA
    amphisome membrane GO:1904930 IEA
 Experiment description of studies that identified CHMP4BP1 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CHMP4BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP4B 128866
Cross-Linking-MS (XL-MS) Homo sapiens
2 PTEN 5728
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CHMP4BP1 is involved
No pathways found





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