Gene description for PTEN
Gene name phosphatase and tensin homolog
Gene symbol PTEN
Other names/aliases 10q23del
BZS
CWS1
DEC
GLM2
MHAM
MMAC1
PTEN1
TEP1
Species Homo sapiens
 Database cross references - PTEN
ExoCarta ExoCarta_5728
Vesiclepedia VP_5728
Entrez Gene 5728
HGNC 9588
MIM 601728
UniProt P60484  
 PTEN identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTEN
Molecular Function
    phosphatidylinositol-3-phosphatase activity GO:0004438 IDA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IEA
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0016314 TAS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    platelet-derived growth factor receptor binding GO:0005161 IEA
    PDZ domain binding GO:0030165 IPI
    protein kinase binding GO:0019901 IEA
    protein tyrosine phosphatase activity GO:0004725 IDA
    anaphase-promoting complex binding GO:0010997 IPI
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity GO:0051800 TAS
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 TAS
    protein serine/threonine phosphatase activity GO:0004722 IDA
    phosphoprotein phosphatase activity GO:0004721 IDA
    magnesium ion binding GO:0000287 IEA
    lipid binding GO:0008289 IEA
Biological Process
    negative regulation of focal adhesion assembly GO:0051895 IMP
    central nervous system development GO:0007417 ISS
    negative regulation of synaptic vesicle clustering GO:2000808 ISS
    response to estradiol GO:0032355 IEA
    negative regulation of cell aging GO:0090344 IEA
    rhythmic synaptic transmission GO:0060024 ISS
    negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 IDA
    postsynaptic density assembly GO:0097107 ISS
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS
    inositol phosphate metabolic process GO:0043647 TAS
    synapse maturation GO:0060074 ISS
    endothelial cell migration GO:0043542 IEA
    multicellular organismal response to stress GO:0033555 ISS
    response to arsenic-containing substance GO:0046685 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    forebrain morphogenesis GO:0048853 ISS
    maternal behavior GO:0042711 IEA
    negative regulation of cell size GO:0045792 ISS
    regulation of cellular component size GO:0032535 ISS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    response to glucose GO:0009749 IEA
    central nervous system myelin maintenance GO:0032286 ISS
    prepulse inhibition GO:0060134 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    dentate gyrus development GO:0021542 ISS
    response to ATP GO:0033198 IEA
    heart development GO:0007507 ISS
    long term synaptic depression GO:0060292 IEA
    apoptotic process GO:0006915 ISS
    dendritic spine morphogenesis GO:0060997 ISS
    protein kinase B signaling GO:0043491 ISS
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IDA
    learning or memory GO:0007611 ISS
    negative regulation of protein phosphorylation GO:0001933 IDA
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    locomotory behavior GO:0007626 ISS
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP
    cell proliferation GO:0008283 TAS
    prostate gland growth GO:0060736 IEA
    negative regulation of dendritic spine morphogenesis GO:0061002 ISS
    innate immune response GO:0045087 TAS
    negative regulation of axonogenesis GO:0050771 ISS
    synapse assembly GO:0007416 ISS
    memory GO:0007613 IEA
    regulation of neuron projection development GO:0010975 ISS
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    protein dephosphorylation GO:0006470 TAS
    negative regulation of organ growth GO:0046621 ISS
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    neuron-neuron synaptic transmission GO:0007270 ISS
    positive regulation of cell proliferation GO:0008284 ISS
    T cell receptor signaling pathway GO:0050852 TAS
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    activation of APC-Cdc20 complex activity GO:0007092 IDA
    negative regulation of phagocytosis GO:0050765 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    angiogenesis GO:0001525 IEA
    negative regulation of ribosome biogenesis GO:0090071 IEA
    small molecule metabolic process GO:0044281 TAS
    response to zinc ion GO:0010043 IEA
    negative regulation of cell proliferation GO:0008285 IMP
    presynaptic membrane assembly GO:0097105 ISS
    central nervous system neuron axonogenesis GO:0021955 ISS
    regulation of protein stability GO:0031647 IMP
    negative regulation of excitatory postsynaptic membrane potential GO:0090394 ISS
    phosphatidylinositol dephosphorylation GO:0046856 IMP
    cardiac muscle tissue development GO:0048738 IEA
    inositol phosphate dephosphorylation GO:0046855 IDA
    negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IDA
    negative regulation of protein kinase B signaling GO:0051898 IMP
    negative regulation of cell migration GO:0030336 IMP
    cell migration GO:0016477 ISS
    phospholipid metabolic process GO:0006644 TAS
    regulation of myeloid cell apoptotic process GO:0033032 IEA
    negative regulation of myelination GO:0031642 IEA
    canonical Wnt signaling pathway GO:0060070 IDA
    brain morphogenesis GO:0048854 ISS
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
    male mating behavior GO:0060179 IEA
    response to ethanol GO:0045471 IEA
    gene expression GO:0010467 TAS
    regulation of B cell apoptotic process GO:0002902 IEA
    response to nutrient GO:0007584 IEA
    aging GO:0007568 IEA
    protein stabilization GO:0050821 IDA
    positive regulation of apoptotic signaling pathway GO:2001235 IEA
    long-term synaptic potentiation GO:0060291 IEA
    social behavior GO:0035176 ISS
    locomotor rhythm GO:0045475 ISS
    response to drug GO:0042493 IEA
Subcellular Localization
    cell projection GO:0042995 IDA
    plasma membrane GO:0005886 IDA
    mitochondrion GO:0005739 IEA
    extracellular region GO:0005576 IEA
    neuron projection GO:0043005 ISS
    nucleus GO:0005634 IDA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    myelin sheath adaxonal region GO:0035749 ISS
    Schmidt-Lanterman incisure GO:0043220 ISS
    PML body GO:0016605 IEA
    dendritic spine GO:0043197 IEA
    cytosol GO:0005829 TAS
    postsynaptic membrane GO:0045211 IEA
    cytoplasm GO:0005737 TAS
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified PTEN in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTEN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COPS6 10980
Two-hybrid Homo sapiens
2 MVP 9961
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 ESR1  
Reconstituted Complex Homo sapiens
4 ANG 283
Two-hybrid Homo sapiens
5 AR 367
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 UBE2I 7329
Affinity Capture-Western Homo sapiens
7 UTP14A 10813
Two-hybrid Homo sapiens
8 MAGI3 260425
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 PTK2 5747
Affinity Capture-Western Homo sapiens
10 CSNK2A1 1457
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
11 CAV1 857
Affinity Capture-Western Homo sapiens
12 HBA1 3039
Two-hybrid Homo sapiens
13 PXN  
Invivo Homo sapiens
14 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 UBE2L3 7332
Affinity Capture-Western Homo sapiens
16 CSNK2A2 1459
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
17 CHGB 1114
Two-hybrid Homo sapiens
View the network image/svg+xml



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