Experiment description of studies that identified ERBB3 in exosomes

1 Experiment ID 1203 MISEV standards ✔ EM EV Biophysical techniques ✔ SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A EV Enriched markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 34887515     Organism Homo sapiens Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Journal name Nat Cell Biol Publication year 2021 Sample Colorectal cancer cells Sample name DiFi Isolation/purification methods Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Western blotting Mass spectrometry RNA sequencing

2 Experiment ID 224 MISEV standards ✔ EM|AFM EV Biophysical techniques ✔ Alix|TSG101|CD63|CD81 EV Enriched markers ✔ GOLGA2 EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25944692     Organism Homo sapiens Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S Journal name Oncotarget Publication year 2015 Sample Neuroblastoma cells Sample name SH-SY5Y Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.10 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting

Protein-protein interactions for ERBB3

Protein Interactor ExoCarta ID Identification method PubMed Species 1 PA2G4 5036 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 2 EGF 1950 Reconstituted Complex Homo sapiens 3 NRG1 3084 Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens 4 ERBB2 2064 Invivo Homo sapiens 5 GRB2 2885 Affinity Capture-MS Homo sapiens 6 SHC1 6464 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 7 CSK 1445 Affinity Capture-MS Homo sapiens 8 RGS4   Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 9 RNF41   Reconstituted Complex Homo sapiens 10 NRG2 9542 Invivo Homo sapiens Invitro Homo sapiens 11 SOS1 6654 Invivo Homo sapiens Invitro Homo sapiens 12 EGFR 1956 Invivo Homo sapiens 13 Shc1   Affinity Capture-Western Mus musculus 14 PTK2 5747 Invivo Homo sapiens Affinity Capture-MS Homo sapiens 15 ERBB3 2065 Invitro Homo sapiens Affinity Capture-MS Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens 16 ZNF207 7756 Two-hybrid Homo sapiens 17 GRB7 2886 Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 18 PTK6   Invivo Homo sapiens 19 IL6ST 3572 Invivo Homo sapiens 20 KIAA1229   Two-hybrid Homo sapiens 21 EGR1   Two-hybrid Homo sapiens 22 PIK3R2 5296 Affinity Capture-MS Homo sapiens 23 PTGES3 10728 Invitro Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 24 MUC1 4582 Invivo Homo sapiens 25 RPN1 6184 Two-hybrid Homo sapiens 26 PIK3R1 5295 Invivo Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 27 CD82 3732 Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens View the network

Pathways in which ERBB3 is involved

No pathways found