Gene description for ERBB3
Gene name erb-b2 receptor tyrosine kinase 3
Gene symbol ERBB3
Other names/aliases ErbB-3
HER3
LCCS2
MDA-BF-1
c-erbB-3
c-erbB3
erbB3-S
p180-ErbB3
p45-sErbB3
p85-sErbB3
Species Homo sapiens
 Database cross references - ERBB3
ExoCarta ExoCarta_2065
Entrez Gene 2065
HGNC 3431
MIM 190151
UniProt P21860  
 ERBB3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ERBB3
Molecular Function
    growth factor binding GO:0019838 ISS
    ATP binding GO:0005524 IEA
    protein heterodimerization activity GO:0046982 IPI
    protein homodimerization activity GO:0042803 NAS
    protein binding GO:0005515 IPI
    transmembrane signaling receptor activity GO:0004888 ISS
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activator activity GO:0030296 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    endocardial cushion development GO:0003197 IEA
    heart development GO:0007507 ISS
    neuron apoptotic process GO:0051402 IMP
    regulation of cell proliferation GO:0042127 IDA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    negative regulation of secretion GO:0051048 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IMP
    wound healing GO:0042060 NAS
    positive regulation of protein tyrosine kinase activity GO:0061098 IMP
    phosphatidylinositol 3-kinase signaling GO:0014065 IDA
    signal transduction GO:0007165 IDA
    peripheral nervous system development GO:0007422 ISS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 TAS
    Schwann cell differentiation GO:0014037 ISS
    negative regulation of signal transduction GO:0009968 IDA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    protein phosphorylation GO:0006468 IEA
    innate immune response GO:0045087 TAS
    negative regulation of cell adhesion GO:0007162 IDA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 ISS
    cranial nerve development GO:0021545 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IEA
    basolateral plasma membrane GO:0016323 IDA
    extracellular space GO:0005615 IDA
    integral component of plasma membrane GO:0005887 TAS
    intracellular GO:0005622 TAS
    lateral plasma membrane GO:0016328 IEA
    receptor complex GO:0043235 ISS
 Experiment description of studies that identified ERBB3 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ERBB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PA2G4 5036
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 EGF 1950
Reconstituted Complex Homo sapiens
3 ERBB2 2064
Invivo Homo sapiens
4 GRB2 2885
Affinity Capture-MS Homo sapiens
5 SHC1 6464
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CSK 1445
Affinity Capture-MS Homo sapiens
7 RGS4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 RNF41  
Reconstituted Complex Homo sapiens
9 NRG2 9542
Invivo Homo sapiens
Invitro Homo sapiens
10 EGFR 1956
Invivo Homo sapiens
11 Shc1  
Affinity Capture-Western Mus musculus
12 PTK2 5747
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
13 ERBB3 2065
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
14 ZNF207 7756
Two-hybrid Homo sapiens
15 GRB7 2886
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
16 PTK6  
Invivo Homo sapiens
17 IL6ST 3572
Invivo Homo sapiens
18 KIAA1229  
Two-hybrid Homo sapiens
19 NRG1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
20 EGR1  
Two-hybrid Homo sapiens
21 PIK3R2  
Affinity Capture-MS Homo sapiens
22 PTGES3 10728
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
23 MUC1 4582
Invivo Homo sapiens
24 RPN1 6184
Two-hybrid Homo sapiens
25 PIK3R1 5295
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
26 SOS1  
Invivo Homo sapiens
Invitro Homo sapiens
27 CD82 3732
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ERBB3 is involved
No pathways found





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