Gene description for VAV1
Gene name vav 1 guanine nucleotide exchange factor
Gene symbol VAV1
Other names/aliases VAV
Species Homo sapiens
 Database cross references - VAV1
ExoCarta ExoCarta_7409
Vesiclepedia VP_7409
Entrez Gene 7409
HGNC 12657
MIM 164875
UniProt P15498  
 VAV1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for VAV1
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    guanyl-nucleotide exchange factor activity GO:0005085 EXP
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    phosphorylation-dependent protein binding GO:0140031 IEA
Biological Process
    immune response-regulating cell surface receptor signaling pathway GO:0002768 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    integrin-mediated signaling pathway GO:0007229 IEA
    small GTPase-mediated signal transduction GO:0007264 IBA
    regulation of cell size GO:0008361 IGI
    regulation of cell size GO:0008361 IGI
    cell migration GO:0016477 IBA
    natural killer cell activation GO:0030101 IDA
    platelet activation GO:0030168 TAS
    T cell differentiation GO:0030217 IEA
    neutrophil chemotaxis GO:0030593 IEA
    T cell costimulation GO:0031295 IDA
    T cell costimulation GO:0031295 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    natural killer cell mediated cytotoxicity GO:0042267 IDA
    regulation of GTPase activity GO:0043087 IGI
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IEA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA
    cellular response to xenobiotic stimulus GO:0071466 TAS
    reactive oxygen species metabolic process GO:0072593 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
 Experiment description of studies that identified VAV1 in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VAV1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
2 HACD3 51495
Affinity Capture-MS Homo sapiens
3 ABLIM1 3983
Affinity Capture-MS Homo sapiens
4 PTPN22  
Affinity Capture-MS Homo sapiens
5 LDHB 3945
Affinity Capture-MS Homo sapiens
6 CHP1 11261
Affinity Capture-MS Homo sapiens
7 SRPRB 58477
Affinity Capture-MS Homo sapiens
8 RACGAP1 29127
Reconstituted Complex Homo sapiens
9 TARDBP 23435
Affinity Capture-MS Homo sapiens
10 PIP5K1C  
Affinity Capture-MS Homo sapiens
11 SOCS1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 COPE 11316
Affinity Capture-MS Homo sapiens
13 CFL1 1072
Affinity Capture-MS Homo sapiens
14 ALOX12B  
Affinity Capture-MS Homo sapiens
15 MSI1  
Affinity Capture-MS Homo sapiens
16 TOMM22 56993
Affinity Capture-MS Homo sapiens
17 POTEE 445582
Affinity Capture-MS Homo sapiens
18 IL6ST 3572
Reconstituted Complex Homo sapiens
19 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
20 PLCG2 5336
Affinity Capture-Western Homo sapiens
21 SPECC1L 23384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RAF1 5894
Affinity Capture-Western Homo sapiens
23 APBB2  
Affinity Capture-MS Homo sapiens
24 ZAP70 7535
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
25 KHDRBS1 10657
Protein-peptide Homo sapiens
26 SYK 6850
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 RHOA 387
FRET Homo sapiens
28 PLCG1 5335
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
29 NUB1 51667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ATP5O 539
Affinity Capture-MS Homo sapiens
31 SERPINH1 871
Affinity Capture-MS Homo sapiens
32 TUBB4A 10382
Affinity Capture-MS Homo sapiens
33 EED  
Affinity Capture-Western Homo sapiens
34 ATG16L1 55054
Affinity Capture-MS Homo sapiens
35 Mbp 17196
Protein-peptide Mus musculus
36 CD28  
Affinity Capture-Western Homo sapiens
37 SIAH2 6478
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
38 CBLB 868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
39 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
40 FGFR1 2260
Protein-peptide Homo sapiens
41 WDR1 9948
Affinity Capture-MS Homo sapiens
42 MAPK1 5594
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 XPO1 7514
Affinity Capture-MS Homo sapiens
44 ACTA2 59
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RPL22L1 200916
Affinity Capture-MS Homo sapiens
46 PPIB 5479
Affinity Capture-MS Homo sapiens
47 DSG1 1828
Affinity Capture-MS Homo sapiens
48 PLBD1 79887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 EMD 2010
Two-hybrid Homo sapiens
50 PDGFRB 5159
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
51 ERBB3 2065
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
52 SBSN 374897
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TMOD1  
Affinity Capture-MS Homo sapiens
54 TUBA1A 7846
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
55 CBL 867
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 TEC 7006
Affinity Capture-Western Homo sapiens
57 APLP2 334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 PAG1 55824
Reconstituted Complex Homo sapiens
59 SP110  
Affinity Capture-MS Homo sapiens
60 TYK2 7297
Affinity Capture-Western Homo sapiens
61 FLOT1 10211
Affinity Capture-MS Homo sapiens
62 LIN7C 55327
Affinity Capture-MS Homo sapiens
63 PTK2B 2185
Reconstituted Complex Homo sapiens
64 CHEK1  
Affinity Capture-MS Homo sapiens
65 S100B 6285
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
66 PRLR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
68 BTK 695
Affinity Capture-Western Homo sapiens
69 SH3BP2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
70 TECR 9524
Affinity Capture-MS Homo sapiens
71 EPOR  
Affinity Capture-Western Homo sapiens
72 FLOT2 2319
Affinity Capture-MS Homo sapiens
73 CCDC115 84317
Affinity Capture-MS Homo sapiens
74 LAT 27040
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
75 TUBB 203068
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 PRDX4 10549
Affinity Capture-MS Homo sapiens
77 SLA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
78 PTPN6 5777
Reconstituted Complex Homo sapiens
79 NME1-NME2 654364
Affinity Capture-MS Homo sapiens
80 SLC25A22  
Affinity Capture-MS Homo sapiens
81 SHB 6461
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
82 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 ERBB4 2066
Reconstituted Complex Homo sapiens
84 EGFR 1956
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
85 FARP2 9855
Affinity Capture-MS Homo sapiens
86 SUZ12  
Affinity Capture-Western Homo sapiens
87 GAB1  
Reconstituted Complex Homo sapiens
88 CDC42 998
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
89 JUN 3725
Biochemical Activity Homo sapiens
90 PRKCQ 5588
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
91 CD5 921
Co-fractionation Homo sapiens
92 TMOD2 29767
Affinity Capture-MS Homo sapiens
93 PALM2-AKAP2 445815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 FYN 2534
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
95 CST6  
Affinity Capture-MS Homo sapiens
96 VDAC1 7416
Affinity Capture-MS Homo sapiens
97 KIAA0368 23392
Affinity Capture-MS Homo sapiens
98 SDR9C7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ABCD3 5825
Affinity Capture-MS Homo sapiens
100 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
101 XRCC5 7520
Affinity Capture-Western Homo sapiens
102 SF3B5 83443
Affinity Capture-MS Homo sapiens
103 ANKFY1 51479
Affinity Capture-MS Homo sapiens
104 DOCK2 1794
Affinity Capture-Western Homo sapiens
105 SERPINA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 CD19 930
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 BLOC1S2 282991
Affinity Capture-MS Homo sapiens
108 PLEC 5339
Affinity Capture-MS Homo sapiens
109 PHAX  
Two-hybrid Homo sapiens
110 PDIA4 9601
Affinity Capture-MS Homo sapiens
111 NUP93 9688
Affinity Capture-MS Homo sapiens
112 RIF1  
Affinity Capture-MS Homo sapiens
113 CDSN 1041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 ABL1 25
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
115 INSR 3643
Reconstituted Complex Homo sapiens
116 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
117 KLK7 5650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 ARF4 378
Affinity Capture-MS Homo sapiens
119 MAP2K1 5604
Affinity Capture-Western Homo sapiens
120 HNRNPK 3190
Affinity Capture-Western Homo sapiens
121 ARHGDIB 397
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
122 DDX39A 10212
Affinity Capture-MS Homo sapiens
123 DOK1 1796
Protein-peptide Homo sapiens
124 RUVBL1 8607
Affinity Capture-MS Homo sapiens
125 EZH2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
126 FARSA 2193
Affinity Capture-MS Homo sapiens
127 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 LCP2 3937
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
129 SERPINB2 5055
Affinity Capture-MS Homo sapiens
130 C14orf166 51637
Affinity Capture-MS Homo sapiens
131 XRCC6 2547
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
132 DNAJC1 64215
Affinity Capture-MS Homo sapiens
133 ATP5C1 509
Affinity Capture-MS Homo sapiens
134 AR 367
Reconstituted Complex Homo sapiens
135 BLNK  
Affinity Capture-Western Homo sapiens
136 RAC1 5879
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
137 SPI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
138 JAK2 3717
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
139 NOTCH1 4851
Affinity Capture-MS Homo sapiens
140 SEC61A1 29927
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which VAV1 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Azathioprine ADME TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent Vav1 pathway TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Costimulation by the CD28 family TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Death Receptor Signaling TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Drug ADME TAS Reactome
Erythropoietin activates RAS IEA Reactome
Erythropoietin activates RAS TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis IEA Reactome
G alpha (12/13) signalling events TAS Reactome
GPCR downstream signalling TAS Reactome
GPVI-mediated activation cascade IEA Reactome
GPVI-mediated activation cascade TAS Reactome
Hemostasis IEA Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Leishmania infection TAS Reactome
Leishmania infection IEA Reactome
Leishmania phagocytosis TAS Reactome
Leishmania phagocytosis IEA Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
NRAGE signals death through JNK TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
Parasite infection TAS Reactome
Parasite infection IEA Reactome
Parasitic Infection Pathways TAS Reactome
Parasitic Infection Pathways IEA Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation IEA Reactome
Platelet activation, signaling and aggregation TAS Reactome
Potential therapeutics for SARS TAS Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Regulation of signaling by CBL TAS Reactome
RHO GTPase cycle TAS Reactome
RHOA GTPase cycle TAS Reactome
RHOG GTPase cycle TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by VEGF TAS Reactome
Signaling by VEGF IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated vascular permeability TAS Reactome
Viral Infection Pathways TAS Reactome





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