Gene description for SIAH2
Gene name	siah E3 ubiquitin protein ligase 2
Gene symbol	SIAH2
Other names/aliases	hSiah2
Species	Homo sapiens
Database cross references - SIAH2
ExoCarta	ExoCarta_6478
Vesiclepedia	VP_6478
Entrez Gene	6478
HGNC	10858
MIM	602213
UniProt	O43255
SIAH2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for SIAH2

Molecular Function     transcription corepressor activity GO:0003714 TAS     ubiquitin-protein transferase activity GO:0004842 ISS     ubiquitin-protein transferase activity GO:0004842 TAS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     ubiquitin conjugating enzyme binding GO:0031624 IBA     ubiquitin protein ligase activity GO:0061630 IBA     ubiquitin protein ligase activity GO:0061630 ISS Biological Process     ubiquitin-dependent protein catabolic process GO:0006511 IMP     ubiquitin-dependent protein catabolic process GO:0006511 ISS     apoptotic process GO:0006915 IEA     small GTPase-mediated signal transduction GO:0007264 TAS     protein ubiquitination GO:0016567 IEA     regulation of protein ubiquitination GO:0031396 IEA     regulation of circadian rhythm GO:0042752 IMP     negative regulation of apoptotic process GO:0043066 IMP     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA     negative regulation of DNA-templated transcription GO:0045892 IEA     rhythmic process GO:0048511 IEA     canonical Wnt signaling pathway GO:0060070 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 IGI     amyloid fibril formation GO:1990000 TAS     negative regulation of cysteine-type endopeptidase activity GO:2000117 IMP     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP Subcellular Localization     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IBA     early endosome GO:0005769 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     neuronal cell body GO:0043025 IEA     intracellular membrane-bounded organelle GO:0043231 IDA