Gene description for HDAC3
Gene name	histone deacetylase 3
Gene symbol	HDAC3
Other names/aliases	HD3 RPD3 RPD3-2
Species	Homo sapiens
Database cross references - HDAC3
ExoCarta	ExoCarta_8841
Vesiclepedia	VP_8841
Entrez Gene	8841
HGNC	4854
MIM	605166
UniProt	O15379
HDAC3 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for HDAC3

Molecular Function     transcription corepressor binding GO:0001222 IPI     chromatin binding GO:0003682 IDA     transcription corepressor activity GO:0003714 IDA     transcription corepressor activity GO:0003714 IMP     transcription corepressor activity GO:0003714 ISS     histone deacetylase activity GO:0004407 IBA     histone deacetylase activity GO:0004407 IDA     histone deacetylase activity GO:0004407 IMP     histone deacetylase activity GO:0004407 TAS     protein binding GO:0005515 IPI     enzyme binding GO:0019899 IPI     cyclin binding GO:0030332 IPI     histone H3K14 deacetylase activity, hydrolytic mechanism GO:0031078 IEA     chromatin DNA binding GO:0031490 IEA     histone H3K9 deacetylase activity, hydrolytic mechanism GO:0032129 IEA     protein lysine deacetylase activity GO:0033558 IDA     protein lysine deacetylase activity GO:0033558 TAS     histone H4K16 deacetylase activity, hydrolytic mechanism GO:0034739 IEA     histone deacetylase binding GO:0042826 IPI     tubulin deacetylase activity GO:0042903 IEA     NF-kappaB binding GO:0051059 IPI     DNA-binding transcription factor binding GO:0140297 TAS     histone H4K12 deacetylase activity, hydrolytic mechanism GO:0140937 IEA     protein decrotonylase activity GO:0160008 IDA     histone decrotonylase activity GO:0160009 IDA     protein de-2-hydroxyisobutyrylase activity GO:0160010 IDA     protein lysine delactylase activity GO:0160216 IDA     histone H4K5 deacetylase activity, hydrolytic mechanism GO:0180032 IEA     histone H4K8 deacetylase activity, hydrolytic mechanism GO:0180033 IEA     histone H3K4 deacetylase activity, hydrolytic mechanism GO:1990162 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     establishment of mitotic spindle orientation GO:0000132 IDA     in utero embryonic development GO:0001701 IEA     positive regulation of protein phosphorylation GO:0001934 IDA     chromatin organization GO:0006325 TAS     transcription by RNA polymerase II GO:0006366 IEA     protein deacetylation GO:0006476 IDA     regulation of mitotic cell cycle GO:0007346 IEA     negative regulation of myotube differentiation GO:0010832 IMP     positive regulation of protein ubiquitination GO:0031398 ISS     regulation of protein stability GO:0031647 IDA     positive regulation of TOR signaling GO:0032008 IMP     circadian regulation of gene expression GO:0032922 ISS     regulation of multicellular organism growth GO:0040014 IEA     epigenetic regulation of gene expression GO:0040029 IBA     positive regulation of protein import into nucleus GO:0042307 IDA     regulation of circadian rhythm GO:0042752 ISS     negative regulation of apoptotic process GO:0043066 TAS     negative regulation of DNA-templated transcription GO:0045892 IEA     negative regulation of DNA-templated transcription GO:0045892 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     negative regulation of JNK cascade GO:0046329 IMP     spindle assembly GO:0051225 IMP     random inactivation of X chromosome GO:0060816 IEA     neural precursor cell proliferation GO:0061351 IEA     establishment of skin barrier GO:0061436 IEA     cellular response to fluid shear stress GO:0071498 IDA     positive regulation of cold-induced thermogenesis GO:0120162 ISS     DNA repair-dependent chromatin remodeling GO:0140861 IDA     cornified envelope assembly GO:1903575 IEA     negative regulation of cardiac muscle cell differentiation GO:2000726 IEA Subcellular Localization     histone deacetylase complex GO:0000118 IDA     histone deacetylase complex GO:0000118 TAS     chromatin GO:0000785 IEA     nucleus GO:0005634 IDA     nucleus GO:0005634 TAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 TAS     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 IDA     plasma membrane GO:0005886 IDA     transcription repressor complex GO:0017053 IDA     mitotic spindle GO:0072686 IDA