Gene description for HDAC3
Gene name	histone deacetylase 3
Gene symbol	HDAC3
Other names/aliases	HD3 RPD3 RPD3-2
Species	Homo sapiens
Database cross references - HDAC3
ExoCarta	ExoCarta_8841
Entrez Gene	8841
HGNC	4854
MIM	605166
UniProt	O15379
HDAC3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for HDAC3

Molecular Function     NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372 IEA     chromatin binding GO:0003682 IDA     histone deacetylase binding GO:0042826 IPI     transcription corepressor activity GO:0003714 ISS     cyclin binding GO:0030332 IPI     NF-kappaB binding GO:0051059 IPI     NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 IEA     enzyme binding GO:0019899 IPI     transcription factor binding GO:0008134 TAS     histone deacetylase activity GO:0004407 TAS     protein deacetylase activity GO:0033558 IDA     protein binding GO:0005515 IPI     chromatin DNA binding GO:0031490 IEA     NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IEA     NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 IEA Biological Process     histone H3-K9 modification GO:0061647 IEA     circadian regulation of gene expression GO:0032922 IEA     negative regulation of transcription, DNA-templated GO:0045892 IMP     negative regulation of apoptotic process GO:0043066 TAS     protein deacetylation GO:0006476 IDA     cellular response to fluid shear stress GO:0071498 IDA     histone H3-K9 deacetylation GO:1990619 IEA     spindle assembly GO:0051225 IMP     positive regulation of transcription factor import into nucleus GO:0042993 IDA     transcription, DNA-templated GO:0006351 IEA     small molecule metabolic process GO:0044281 TAS     negative regulation of myotube differentiation GO:0010832 IMP     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     negative regulation of JNK cascade GO:0046329 IMP     Notch signaling pathway GO:0007219 TAS     regulation of mitotic cell cycle GO:0007346 IEA     chromatin modification GO:0016568 TAS     negative regulation of cell cycle GO:0045786 TAS     circadian rhythm GO:0007623 TAS     positive regulation of protein phosphorylation GO:0001934 IDA     histone H4 deacetylation GO:0070933 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     cellular lipid metabolic process GO:0044255 TAS     chromatin organization GO:0006325 TAS     regulation of multicellular organism growth GO:0040014 IEA     regulation of protein stability GO:0031647 IDA     positive regulation of TOR signaling GO:0032008 IMP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     negative regulation of nucleic acid-templated transcription GO:1903507 ISS Subcellular Localization     cytoplasm GO:0005737 TAS     nucleus GO:0005634 TAS     transcriptional repressor complex GO:0017053 IDA     histone deacetylase complex GO:0000118 TAS     nucleoplasm GO:0005654 TAS     spindle microtubule GO:0005876 IDA     plasma membrane GO:0005886 IDA     Golgi apparatus GO:0005794 IDA