Gene description for DNMT1
Gene name	DNA (cytosine-5-)-methyltransferase 1
Gene symbol	DNMT1
Other names/aliases	ADCADN AIM CXXC9 DNMT HSN1E MCMT
Species	Homo sapiens
Database cross references - DNMT1
ExoCarta	ExoCarta_1786
Entrez Gene	1786
HGNC	2976
MIM	126375
UniProt	P26358
DNMT1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513

Gene ontology annotations for DNMT1

Molecular Function     DNA (cytosine-5-)-methyltransferase activity GO:0003886 IDA     DNA binding GO:0003677 IDA     zinc ion binding GO:0008270 IEA     protein binding GO:0005515 IPI     methyl-CpG binding GO:0008327 IEA     DNA-methyltransferase activity GO:0009008 TAS     RNA binding GO:0003723 IEA     transcription factor binding GO:0008134 IEA     chromatin binding GO:0003682 IEA Biological Process     C-5 methylation of cytosine GO:0090116 IEA     positive regulation of histone H3-K4 methylation GO:0051571 IMP     positive regulation of gene expression GO:0010628 IMP     gene silencing GO:0016458 IEA     chromatin modification GO:0016568 IEA     negative regulation of histone H3-K9 methylation GO:0051573 IMP     regulation of gene expression, epigenetic GO:0040029 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     negative regulation of gene expression, epigenetic GO:0045814 TAS     cellular response to amino acid stimulus GO:0071230 IEA     maintenance of DNA methylation GO:0010216 IDA     DNA methylation GO:0006306 TAS     transcription, DNA-templated GO:0006351 IEA     regulation of cell proliferation GO:0042127 IEA     gene expression GO:0010467 TAS     DNA methylation on cytosine GO:0032776 TAS Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     pericentric heterochromatin GO:0005721 IEA     replication fork GO:0005657 IEA