Gene description for CLPB
Gene name ClpB homolog, mitochondrial AAA ATPase chaperonin
Gene symbol CLPB
Other names/aliases ANKCLB
HSP78
MEGCANN
MGCA7
SKD3
Species Homo sapiens
 Database cross references - CLPB
ExoCarta ExoCarta_81570
Vesiclepedia VP_81570
Entrez Gene 81570
HGNC 30664
MIM 616254
UniProt Q9H078  
 CLPB identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CLPB
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IMP
    cohesin loader activity GO:0061775 IEA
    ATP-dependent protein disaggregase activity GO:0140545 IDA
    ATP-dependent protein disaggregase activity GO:0140545 IMP
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    granulocyte differentiation GO:0030851 IMP
    cellular response to heat GO:0034605 IBA
    cellular response to heat GO:0034605 IDA
    RIG-I signaling pathway GO:0039529 IDA
    antiviral innate immune response GO:0140374 IDA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial intermembrane space GO:0005758 IMP
 Experiment description of studies that identified CLPB in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CLPB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REC8  
Affinity Capture-MS Homo sapiens
2 MRPS27 23107
Proximity Label-MS Homo sapiens
3 AFG3L2 10939
Proximity Label-MS Homo sapiens
4 MTFP1  
Affinity Capture-MS Homo sapiens
5 IARS2 55699
Proximity Label-MS Homo sapiens
6 OSBPL10  
Affinity Capture-MS Homo sapiens
7 Hax1  
Affinity Capture-MS Mus musculus
8 COQ9  
Affinity Capture-MS Homo sapiens
9 ADCK3  
Affinity Capture-MS Homo sapiens
10 NDUFS1 4719
Proximity Label-MS Homo sapiens
11 SAMM50 25813
Proximity Label-MS Homo sapiens
12 GTPBP10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PTPMT1 114971
Affinity Capture-MS Homo sapiens
14 TRUB2  
Affinity Capture-MS Homo sapiens
15 SLC25A48  
Affinity Capture-MS Homo sapiens
16 NDUFA4 4697
Affinity Capture-MS Homo sapiens
17 SETDB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PSMB8 5696
Affinity Capture-MS Homo sapiens
19 APEX1 328
Affinity Capture-RNA Homo sapiens
20 PPTC7 160760
Affinity Capture-MS Homo sapiens
21 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
22 TRMU  
Affinity Capture-MS Homo sapiens
23 CEP70  
Two-hybrid Homo sapiens
24 HSPA2 3306
Affinity Capture-MS Homo sapiens
25 CEMIP 57214
Affinity Capture-MS Homo sapiens
26 MCM2 4171
Affinity Capture-MS Homo sapiens
27 TRAPPC2L 51693
Affinity Capture-MS Homo sapiens
28 COPS6 10980
Affinity Capture-MS Homo sapiens
29 MRPS5 64969
Proximity Label-MS Homo sapiens
30 NDUFA5 4698
Proximity Label-MS Homo sapiens
31 MRPS24 64951
Proximity Label-MS Homo sapiens
32 CHCHD10  
Affinity Capture-MS Homo sapiens
33 ZFYVE1 53349
Affinity Capture-MS Homo sapiens
34 KIAA1191  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SURF1  
Proximity Label-MS Homo sapiens
36 FAM136A 84908
Affinity Capture-MS Homo sapiens
37 NDUFV3 4731
Proximity Label-MS Homo sapiens
38 MRPS7 51081
Proximity Label-MS Homo sapiens
39 ADCK4 79934
Affinity Capture-MS Homo sapiens
40 RBM14 10432
Affinity Capture-MS Homo sapiens
41 ERCC6L 54821
Affinity Capture-MS Homo sapiens
42 HSPA8 3312
Affinity Capture-MS Homo sapiens
43 CBWD1 55871
Affinity Capture-MS Homo sapiens
44 ARFIP1 27236
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 AMBRA1  
Affinity Capture-MS Homo sapiens
46 DDX19B 11269
Affinity Capture-MS Homo sapiens
47 APOO 79135
Proximity Label-MS Homo sapiens
48 E2F4  
Affinity Capture-MS Homo sapiens
49 MRPS35 60488
Proximity Label-MS Homo sapiens
50 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
51 COX15 1355
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
52 FASTKD5  
Proximity Label-MS Homo sapiens
53 MRPS26 64949
Proximity Label-MS Homo sapiens
54 EXOG 9941
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PARK2  
Affinity Capture-MS Homo sapiens
56 MRPS34 65993
Proximity Label-MS Homo sapiens
57 CHCHD3 54927
Proximity Label-MS Homo sapiens
58 ACOT2 10965
Proximity Label-MS Homo sapiens
59 NDUFA8 4702
Proximity Label-MS Homo sapiens
60 DIABLO 56616
Proximity Label-MS Homo sapiens
61 PAG1 55824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 PTCD3 55037
Proximity Label-MS Homo sapiens
63 ANGPTL7 10218
Affinity Capture-MS Homo sapiens
64 C12orf49  
Negative Genetic Homo sapiens
65 SREBF2 6721
Negative Genetic Homo sapiens
66 NTRK1 4914
Affinity Capture-MS Homo sapiens
67 CDKN3 1033
Affinity Capture-MS Homo sapiens
68 CCDC109B 55013
Proximity Label-MS Homo sapiens
69 OPA1 4976
Proximity Label-MS Homo sapiens
70 CHEK1  
Proximity Label-MS Homo sapiens
71 YWHAQ 10971
Co-fractionation Homo sapiens
72 COA7  
Proximity Label-MS Homo sapiens
73 COQ10B  
Affinity Capture-MS Homo sapiens
74 PAK7  
Affinity Capture-MS Homo sapiens
75 AQP12B  
Affinity Capture-MS Homo sapiens
76 CKMT1B 1159
Proximity Label-MS Homo sapiens
77 COX4I1 1327
Proximity Label-MS Homo sapiens
78 CISD3 284106
Affinity Capture-MS Homo sapiens
79 C15orf48  
Affinity Capture-MS Homo sapiens
80 OGT 8473
Reconstituted Complex Homo sapiens
81 WBSCR16  
Affinity Capture-MS Homo sapiens
82 SLC25A12 8604
Proximity Label-MS Homo sapiens
83 AIFM1 9131
Proximity Label-MS Homo sapiens
84 MTIF2 4528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 NDUFA13 51079
Affinity Capture-MS Homo sapiens
86 XPO1 7514
Affinity Capture-MS Homo sapiens
87 MTX2 10651
Proximity Label-MS Homo sapiens
88 C2orf47  
Affinity Capture-MS Homo sapiens
89 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PDE4D  
Affinity Capture-MS Homo sapiens
91 RMND1 55005
Proximity Label-MS Homo sapiens
92 TRIM11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 DHX30 22907
Proximity Label-MS Homo sapiens
94 TTF2 8458
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RIPK4  
Affinity Capture-MS Homo sapiens
96 PUS7 54517
Affinity Capture-MS Homo sapiens
97 AURKB 9212
Affinity Capture-MS Homo sapiens
98 BIRC6 57448
Proximity Label-MS Homo sapiens
99 C12orf74  
Affinity Capture-MS Homo sapiens
100 ODF3L1  
Affinity Capture-MS Homo sapiens
101 SMAD9  
Two-hybrid Homo sapiens
102 COX6B1 1340
Proximity Label-MS Homo sapiens
103 SEC16A 9919
Affinity Capture-MS Homo sapiens
104 DLST 1743
Proximity Label-MS Homo sapiens
105 DAP3 7818
Proximity Label-MS Homo sapiens
106 HAX1  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
107 PEX3 8504
Proximity Label-MS Homo sapiens
108 MDM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MGEA5 10724
Affinity Capture-MS Homo sapiens
110 HUWE1 10075
Affinity Capture-MS Homo sapiens
111 ICA1  
Affinity Capture-MS Homo sapiens
112 IMMT 10989
Proximity Label-MS Homo sapiens
113 DNAJC4  
Proximity Label-MS Homo sapiens
114 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
115 PHB2 11331
Proximity Label-MS Homo sapiens
116 OCIAD1 54940
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
117 TERF2  
Affinity Capture-MS Homo sapiens
118 SIRT6  
Affinity Capture-MS Homo sapiens
119 PARP1 142
Affinity Capture-MS Homo sapiens
120 FOXRED2  
Affinity Capture-MS Homo sapiens
121 MRPS2 51116
Proximity Label-MS Homo sapiens
122 PPIP5K1 9677
Affinity Capture-MS Homo sapiens
123 C15orf53  
Affinity Capture-MS Homo sapiens
124 DNAJC30  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
125 LONP1 9361
Proximity Label-MS Homo sapiens
126 LRPPRC 10128
Co-fractionation Homo sapiens
127 MRPS31  
Proximity Label-MS Homo sapiens
128 ADCK2  
Affinity Capture-MS Homo sapiens
129 SQSTM1 8878
Proximity Label-MS Homo sapiens
130 C17orf89  
Affinity Capture-MS Homo sapiens
131 TSEN2  
Affinity Capture-MS Homo sapiens
132 CLUH 23277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 OPA3 80207
Affinity Capture-MS Homo sapiens
134 CAPZB 832
Affinity Capture-MS Homo sapiens
135 UCHL3 7347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 SFXN1 94081
Proximity Label-MS Homo sapiens
137 HOXB1  
Affinity Capture-MS Homo sapiens
138 USP30  
Affinity Capture-MS Homo sapiens
139 NDUFS8 4728
Proximity Label-MS Homo sapiens
140 C9orf173  
Affinity Capture-MS Homo sapiens
141 C16orf72 29035
Affinity Capture-MS Homo sapiens
142 TIMM13 26517
Proximity Label-MS Homo sapiens
143 C19orf52  
Proximity Label-MS Homo sapiens
144 SLC25A51  
Proximity Label-MS Homo sapiens
145 CIT 11113
Affinity Capture-MS Homo sapiens
146 DHRS4 10901
Affinity Capture-MS Homo sapiens
147 NAP1L5  
Affinity Capture-MS Homo sapiens
148 SRMS  
Affinity Capture-MS Homo sapiens
149 C9orf72  
Affinity Capture-MS Homo sapiens
150 MOCS3 27304
Affinity Capture-MS Homo sapiens
151 MRPS22 56945
Proximity Label-MS Homo sapiens
152 DNMT1 1786
Cross-Linking-MS (XL-MS) Homo sapiens
153 TIMP3 7078
Affinity Capture-MS Homo sapiens
154 MRPS9 64965
Proximity Label-MS Homo sapiens
155 EP300 2033
Affinity Capture-MS Homo sapiens
156 EIF5 1983
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CLPB is involved
No pathways found





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