Gene description for DDX19B
Gene name DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Gene symbol DDX19B
Other names/aliases DBP5
DDX19
RNAh
Species Homo sapiens
 Database cross references - DDX19B
ExoCarta ExoCarta_11269
Vesiclepedia VP_11269
Entrez Gene 11269
HGNC 2742
MIM 605812
UniProt Q9UMR2  
 DDX19B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for DDX19B
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 TAS
    RNA helicase activity GO:0003724 IBA
    mRNA binding GO:0003729 IBA
    helicase activity GO:0004386 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    mRNA export from nucleus GO:0006406 TAS
    poly(A)+ mRNA export from nucleus GO:0016973 IBA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nuclear envelope GO:0005635 IDA
    nuclear pore GO:0005643 TAS
    nucleoplasm GO:0005654 IEA
    cytoplasm GO:0005737 TAS
    cytoplasmic stress granule GO:0010494 IBA
    membrane GO:0016020 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified DDX19B in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DDX19B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MVP 9961
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 AKR1B10 57016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HMOX1 3162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RAMP3  
Affinity Capture-MS Homo sapiens
5 RHOF 54509
Affinity Capture-MS Homo sapiens
6 HDAC4  
Affinity Capture-MS Homo sapiens
7 ZNF174  
Affinity Capture-MS Homo sapiens
8 SERPINB4 6318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ALOX15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 KLK8 11202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 COIL  
Proximity Label-MS Homo sapiens
12 SHC1 6464
Affinity Capture-MS Homo sapiens
13 POT1  
Two-hybrid Homo sapiens
14 PAEP  
Affinity Capture-MS Homo sapiens
15 KLK5 25818
Affinity Capture-MS Homo sapiens
16 ORM1 5004
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CTBP2 1488
Co-fractionation Homo sapiens
18 CCDC132 55610
Affinity Capture-MS Homo sapiens
19 GADD45A  
Affinity Capture-MS Homo sapiens
20 ANXA8 653145
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 APBA3  
Affinity Capture-MS Homo sapiens
22 CD300LB  
Affinity Capture-MS Homo sapiens
23 S100A7 6278
Affinity Capture-MS Homo sapiens
24 UBC 7316
Reconstituted Complex Homo sapiens
25 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ARL11  
Affinity Capture-MS Homo sapiens
27 IL22RA2  
Affinity Capture-MS Homo sapiens
28 CD79A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SNX21  
Affinity Capture-MS Homo sapiens
30 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
31 APP 351
Reconstituted Complex Homo sapiens
32 HAL 3034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TREX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LRP1 4035
Affinity Capture-MS Homo sapiens
35 SLC18A2  
Affinity Capture-MS Homo sapiens
36 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
37 SERPINA1 5265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 HP 3240
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 BTLA  
Affinity Capture-MS Homo sapiens
40 CAPG 822
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TMEM183A  
Affinity Capture-MS Homo sapiens
42 LGALS1 3956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CARKD 55739
Affinity Capture-MS Homo sapiens
44 C3 718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 FAM174A 345757
Affinity Capture-MS Homo sapiens
46 NDRG2 57447
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 COPS5 10987
Affinity Capture-MS Homo sapiens
48 ACPP 55
Affinity Capture-MS Homo sapiens
49 IQGAP1 8826
Affinity Capture-MS Homo sapiens
50 GLMP 112770
Affinity Capture-MS Homo sapiens
51 GCAT  
Affinity Capture-MS Homo sapiens
52 KLRC1  
Affinity Capture-MS Homo sapiens
53 NARS 4677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PSME1 5720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SULT2B1 6820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MIF4GD 57409
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
57 MALSU1  
Affinity Capture-MS Homo sapiens
58 CLPB 81570
Affinity Capture-MS Homo sapiens
59 ABHD17A 81926
Affinity Capture-MS Homo sapiens
60 FAM196A  
Affinity Capture-MS Homo sapiens
61 GNAZ 2781
Affinity Capture-MS Homo sapiens
62 TRIM25 7706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 KLRC2  
Affinity Capture-MS Homo sapiens
64 SERBP1 26135
Affinity Capture-MS Homo sapiens
65 C1QTNF9B  
Affinity Capture-MS Homo sapiens
66 FBXW5  
Affinity Capture-MS Homo sapiens
67 ACOT6  
Affinity Capture-MS Homo sapiens
68 DVL2 1856
Affinity Capture-MS Homo sapiens
69 IL36RN  
Affinity Capture-MS Homo sapiens
70 FOXP1 27086
Protein-RNA Homo sapiens
71 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 NUP155 9631
Proximity Label-MS Homo sapiens
73 TMEM25  
Affinity Capture-MS Homo sapiens
74 RAB5A 5868
Affinity Capture-MS Homo sapiens
75 ALPI  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 GNG8  
Affinity Capture-MS Homo sapiens
77 POF1B 79983
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ENSA 2029
Affinity Capture-MS Homo sapiens
79 PKM 5315
Affinity Capture-MS Homo sapiens
80 PRPH 5630
Proximity Label-MS Homo sapiens
81 USP11 8237
Affinity Capture-MS Homo sapiens
82 KLHDC2  
Affinity Capture-MS Homo sapiens
83 FGA 2243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 XPO7 23039
Two-hybrid Homo sapiens
85 FCN3 8547
Affinity Capture-MS Homo sapiens
86 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
87 CSTF2 1478
Co-fractionation Homo sapiens
88 SLC39A9 55334
Affinity Capture-MS Homo sapiens
89 SERPINB1 1992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 KLK1 3816
Affinity Capture-MS Homo sapiens
91 CROT 54677
Affinity Capture-MS Homo sapiens
92 MSMB  
Affinity Capture-MS Homo sapiens
93 CALML3 810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 FGG 2266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 IGHG1 3500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 GPR182  
Affinity Capture-MS Homo sapiens
97 F12  
Affinity Capture-MS Homo sapiens
98 GML  
Affinity Capture-MS Homo sapiens
99 EVPL 2125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
101 GPBP1L1  
Affinity Capture-MS Homo sapiens
102 TGM1 7051
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SERPINB7 8710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 DLC1 10395
Affinity Capture-MS Homo sapiens
105 CALML5 51806
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 LYPD4  
Affinity Capture-MS Homo sapiens
107 ARL4C 10123
Affinity Capture-MS Homo sapiens
108 DNM1L 10059
Proximity Label-MS Homo sapiens
109 LY86  
Affinity Capture-MS Homo sapiens
110 LY6H  
Affinity Capture-MS Homo sapiens
111 DDX25  
Affinity Capture-MS Homo sapiens
112 RAB33A 9363
Affinity Capture-MS Homo sapiens
113 CCL22 6367
Affinity Capture-MS Homo sapiens
114 ITLN1 55600
Affinity Capture-MS Homo sapiens
115 SERPINB3 6317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 CCM2 83605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 IRF9 10379
Affinity Capture-MS Homo sapiens
118 IVL 3713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 CXCR4 7852
Affinity Capture-MS Homo sapiens
120 DCK 1633
Two-hybrid Homo sapiens
121 RHOT2 89941
Affinity Capture-MS Homo sapiens
122 TYMP 1890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 APOBEC3A 200315
Affinity Capture-MS Homo sapiens
124 XPO1 7514
Co-fractionation Homo sapiens
125 NPRL3  
Affinity Capture-MS Homo sapiens
126 NAGK 55577
Affinity Capture-MS Homo sapiens
127 C1QA 712
Affinity Capture-MS Homo sapiens
128 NPTN 27020
Affinity Capture-MS Homo sapiens
129 ANXA1 301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 CST8  
Affinity Capture-MS Homo sapiens
131 IGKC 3514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 EPPK1 83481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 MGARP  
Affinity Capture-MS Homo sapiens
134 NR3C1 2908
Proximity Label-MS Homo sapiens
135 LY9 4063
Affinity Capture-MS Homo sapiens
136 GRIN2C 2905
Affinity Capture-MS Homo sapiens
137 TRIM11  
Affinity Capture-MS Homo sapiens
138 CTAG2  
Affinity Capture-MS Homo sapiens
139 LGALS7 3963
Affinity Capture-MS Homo sapiens
140 SERPINB5 5268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 ADAM7  
Affinity Capture-MS Homo sapiens
142 Vps4b 20479
Affinity Capture-MS Mus musculus
143 RRM2 6241
Co-fractionation Homo sapiens
144 ARMC6 93436
Affinity Capture-MS Homo sapiens
145 NRBP1 29959
Affinity Capture-MS Homo sapiens
146 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 NDUFA4 4697
Affinity Capture-MS Homo sapiens
148 RAB2B 84932
Affinity Capture-MS Homo sapiens
149 IL12RB1  
Affinity Capture-MS Homo sapiens
150 ATP2A1 487
Affinity Capture-MS Homo sapiens
151 CTIF  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
152 GPR45  
Affinity Capture-MS Homo sapiens
153 SLC22A2 6582
Affinity Capture-MS Homo sapiens
154 RNASE7 84659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 LGALS7B 653499
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 TNS2 23371
Affinity Capture-MS Homo sapiens
157 ACOX1 51
Affinity Capture-MS Homo sapiens
158 CST9L  
Affinity Capture-MS Homo sapiens
159 ISLR 3671
Affinity Capture-MS Homo sapiens
160 TMPRSS5  
Affinity Capture-MS Homo sapiens
161 KIF25  
Affinity Capture-MS Homo sapiens
162 GNB2L1 10399
Two-hybrid Homo sapiens
163 RAE1 8480
Affinity Capture-MS Homo sapiens
164 PRSS22 64063
Affinity Capture-MS Homo sapiens
165 CFB 629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 LYZL2  
Affinity Capture-MS Homo sapiens
167 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
168 CA6 765
Affinity Capture-MS Homo sapiens
169 ART3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 NSUN5P1  
Affinity Capture-MS Homo sapiens
171 PLEC 5339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 NUBP2 10101
Affinity Capture-MS Homo sapiens
173 L3HYPDH 112849
Affinity Capture-MS Homo sapiens
174 EHD4 30844
Affinity Capture-MS Homo sapiens
175 CTSV 1515
Affinity Capture-MS Homo sapiens
176 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 MFSD4  
Affinity Capture-MS Homo sapiens
178 IGLL5 100423062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 OSTM1 28962
Affinity Capture-MS Homo sapiens
180 CRABP2 1382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 PTCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 LTA  
Affinity Capture-MS Homo sapiens
183 UPK3B  
Affinity Capture-MS Homo sapiens
184 IKBKG 8517
Reconstituted Complex Homo sapiens
185 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 IGHG2 3501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 SFTPA2  
Affinity Capture-MS Homo sapiens
188 SERPINA3 12
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 S100A9 6280
Affinity Capture-MS Homo sapiens
190 DDX19A 55308
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 PPL 5493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 TF 7018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 HOXB1  
Affinity Capture-MS Homo sapiens
194 CEBPA  
Protein-peptide Homo sapiens
195 TERF1 7013
Two-hybrid Homo sapiens
196 CTAG1B  
Affinity Capture-MS Homo sapiens
197 GM2A 2760
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 VWA2 340706
Affinity Capture-MS Homo sapiens
199 C17orf82  
Affinity Capture-MS Homo sapiens
200 STAT3 6774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 GSDMA 284110
Affinity Capture-MS Homo sapiens
202 RTBDN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
204 GSN 2934
Affinity Capture-MS Homo sapiens
205 CST11  
Affinity Capture-MS Homo sapiens
206 SNW1 22938
Affinity Capture-MS Homo sapiens
207 OXCT2  
Affinity Capture-MS Homo sapiens
208 C9orf72  
Affinity Capture-MS Homo sapiens
209 LCN2 3934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 GPHA2  
Affinity Capture-MS Homo sapiens
211 LTF 4057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 TRIM29 23650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
213 FCGBP 8857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
214 ARHGEF10L 55160
Affinity Capture-MS Homo sapiens
215 CLEC4E  
Affinity Capture-MS Homo sapiens
216 LCP1 3936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
217