Gene description for ABHD17A
Gene name abhydrolase domain containing 17A
Gene symbol ABHD17A
Other names/aliases C19orf27
FAM108A1
Species Homo sapiens
 Database cross references - ABHD17A
ExoCarta ExoCarta_81926
Vesiclepedia VP_81926
Entrez Gene 81926
HGNC 28756
UniProt Q96GS6  
 ABHD17A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ABHD17A
Molecular Function
    protein binding GO:0005515 IPI
    palmitoyl-(protein) hydrolase activity GO:0008474 IBA
    palmitoyl-(protein) hydrolase activity GO:0008474 IDA
    palmitoyl-(protein) hydrolase activity GO:0008474 IMP
Biological Process
    protein depalmitoylation GO:0002084 IGI
    protein depalmitoylation GO:0002084 IMP
    protein localization to membrane GO:0072657 IMP
    regulation of postsynapse organization GO:0099175 IBA
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 IDA
    negative regulation of protein localization to microtubule GO:1902817 IEA
    positive regulation of protein localization to endosome GO:1905668 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 IBA
    endosome membrane GO:0010008 IDA
    membrane GO:0016020 HDA
    nuclear speck GO:0016607 IDA
    dendritic spine GO:0043197 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    recycling endosome membrane GO:0055038 IEA
    postsynaptic density membrane GO:0098839 IEA
    postsynaptic recycling endosome membrane GO:0098944 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified ABHD17A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ABHD17A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLEKHH3  
Affinity Capture-MS Homo sapiens
2 BIRC2  
Two-hybrid Homo sapiens
3 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TNIP1 10318
Two-hybrid Homo sapiens
5 GPC4 2239
Two-hybrid Homo sapiens
6 CCT3 7203
Affinity Capture-MS Homo sapiens
7 ABHD17C 58489
Affinity Capture-MS Homo sapiens
8 MDFI  
Two-hybrid Homo sapiens
9 VPS28 51160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 HSPA8 3312
Affinity Capture-MS Homo sapiens
11 CCT2 10576
Affinity Capture-MS Homo sapiens
12 DDX19B 11269
Affinity Capture-MS Homo sapiens
13 LPAR6  
Affinity Capture-MS Homo sapiens
14 CCT6A 908
Affinity Capture-MS Homo sapiens
15 PLSCR4  
Two-hybrid Homo sapiens
16 ACVR2A  
Affinity Capture-MS Homo sapiens
17 GPR12  
Affinity Capture-MS Homo sapiens
18 HPGDS  
Two-hybrid Homo sapiens
19 KRTAP5-9  
Two-hybrid Homo sapiens
20 PNMA1 9240
Two-hybrid Homo sapiens
21 DDX58 23586
Affinity Capture-RNA Homo sapiens
22 TUBA1A 7846
Affinity Capture-MS Homo sapiens
23 Hoxa1  
Two-hybrid Mus musculus
PCA Mus musculus
Affinity Capture-Western Mus musculus
24 GOLGA2 2801
Two-hybrid Homo sapiens
25 PLEKHG4  
Affinity Capture-MS Homo sapiens
26 TCTEX1D2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 EGFR 1956
Negative Genetic Homo sapiens
28 TRIM27  
Two-hybrid Homo sapiens
29 EHMT2 10919
Two-hybrid Homo sapiens
30 SPAG9 9043
Affinity Capture-MS Homo sapiens
31 APLNR  
Affinity Capture-MS Homo sapiens
32 SRC 6714
Affinity Capture-MS Homo sapiens
33 CCZ1 51622
Affinity Capture-MS Homo sapiens
34 RGS20 8601
Two-hybrid Homo sapiens
35 TCP1 6950
Affinity Capture-MS Homo sapiens
36 TRAF1 7185
Two-hybrid Homo sapiens
37 CHMP4A 29082
Affinity Capture-MS Homo sapiens
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