Gene description for TRAF1
Gene name TNF receptor-associated factor 1
Gene symbol TRAF1
Other names/aliases EBI6
MGC:10353
Species Homo sapiens
 Database cross references - TRAF1
ExoCarta ExoCarta_7185
Vesiclepedia VP_7185
Entrez Gene 7185
HGNC 12031
MIM 601711
UniProt Q13077  
 TRAF1 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Thymus 23844026    
 Gene ontology annotations for TRAF1
Molecular Function
    thioesterase binding GO:0031996 IPI
    tumor necrosis factor receptor binding GO:0005164 IPI
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    signal transduction GO:0007165 IEA
    regulation of extrinsic apoptotic signaling pathway GO:2001236 IDA
    protein complex assembly GO:0006461 TAS
    apoptotic process GO:0006915 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
Subcellular Localization
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified TRAF1 in exosomes
1
Experiment ID 259
MISEV standards
EM
EV Biophysical techniques
TSG101|FLOT1
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 217
MISEV standards
EM
EV Biophysical techniques
TSG101|CD81|CD9|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRAF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFAIP3 7128
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 BIRC2  
Invitro Homo sapiens
Invitro Homo sapiens
3 CD40 958
Invivo Homo sapiens
Invitro Homo sapiens
4 CASP8 841
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
5 MAP3K14  
Invitro Homo sapiens
6 TANK 10010
Two-hybrid Homo sapiens
7 USP7 7874
Invitro Homo sapiens
8 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
9 TNFRSF1B  
Invitro Homo sapiens
Two-hybrid Homo sapiens
10 CFLAR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 CASP6 839
Biochemical Activity Homo sapiens
12 TNFRSF8 943
Invivo Homo sapiens
13 TNFRSF17  
Invivo Homo sapiens
14 TNFRSF1A 7132
Invivo Homo sapiens
15 TNFRSF7  
Affinity Capture-Western Homo sapiens
16 CASP10  
Biochemical Activity Homo sapiens
17 TNFRSF18  
Affinity Capture-Western Homo sapiens
18 RIPK1 8737
Invivo Homo sapiens
Invitro Homo sapiens
19 TRIP  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
20 MAP3K5 4217
Affinity Capture-Western Homo sapiens
21 TNFRSF11A  
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
22 TRIM37  
Invitro Homo sapiens
23 NGFR 4804
Affinity Capture-Western Homo sapiens
24 HIVEP3 59269
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
25 RIPK2  
Affinity Capture-Western Homo sapiens
26 TNFRSF9  
Reconstituted Complex Homo sapiens
27 MAP6 4135
Invitro Homo sapiens
28 SRC 6714
Affinity Capture-Western Homo sapiens
29 TRADD 8717
Invivo Homo sapiens
30 TNFRSF19  
Invivo Homo sapiens
31 TNFRSF14  
Invivo Homo sapiens
32 TNFRSF12A 51330
Reconstituted Complex Homo sapiens
33 TNFSF9  
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
34 BIRC3 330
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TRAF1 is involved
No pathways found





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