Gene description for BIRC3
Gene name baculoviral IAP repeat containing 3
Gene symbol BIRC3
Other names/aliases AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
Species Homo sapiens
 Database cross references - BIRC3
ExoCarta ExoCarta_330
Vesiclepedia VP_330
Entrez Gene 330
HGNC 591
MIM 601721
UniProt Q13489  
 BIRC3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BIRC3
Molecular Function
    zinc ion binding GO:0008270 IEA
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IBA
    ligase activity GO:0016874 IEA
Biological Process
    negative regulation of reactive oxygen species metabolic process GO:2000378 IEA
    regulation of innate immune response GO:0045088 TAS
    negative regulation of apoptotic process GO:0043066 TAS
    regulation of necroptotic process GO:0060544 IMP
    positive regulation of protein ubiquitination GO:0031398 IDA
    inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:1990001 IBA
    innate immune response GO:0045087 TAS
    negative regulation of necroptotic process GO:0060546 IBA
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    protein heterooligomerization GO:0051291 IEA
    necroptotic process GO:0070266 TAS
    negative regulation of phosphorylation GO:0042326 IEA
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070424 TAS
    programmed cell death GO:0012501 TAS
    spermatogenesis GO:0007283 IEA
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    programmed necrotic cell death GO:0097300 TAS
    regulation of toll-like receptor signaling pathway GO:0034121 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    toll-like receptor signaling pathway GO:0002224 TAS
    protein ubiquitination GO:0016567 IDA
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    mitotic spindle assembly GO:0090307 IBA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS
    regulation of inflammatory response GO:0050727 TAS
    NIK/NF-kappaB signaling GO:0038061 TAS
    regulation of RIG-I signaling pathway GO:0039535 TAS
    regulation of apoptotic process GO:0042981 IMP
    regulation of necrotic cell death GO:0010939 TAS
    regulation of cysteine-type endopeptidase activity GO:2000116 TAS
Subcellular Localization
    membrane raft GO:0045121 IEA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    spindle microtubule GO:0005876 IBA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified BIRC3 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BIRC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CASP9 842
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 DIABLO 56616
Affinity Capture-Western Homo sapiens
3 TRAF2 7186
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 HTRA2 27429
Reconstituted Complex Homo sapiens
5 CASP7  
Invitro Homo sapiens
6 CASP3 836
Invitro Homo sapiens
7 RIPK2  
Affinity Capture-Western Homo sapiens
8 TRAF1 7185
Invitro Homo sapiens
View the network image/svg+xml



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