Gene description for BIRC3
Gene name baculoviral IAP repeat containing 3
Gene symbol BIRC3
Other names/aliases AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
Species Homo sapiens
 Database cross references - BIRC3
ExoCarta ExoCarta_330
Vesiclepedia VP_330
Entrez Gene 330
HGNC 591
MIM 601721
UniProt Q13489  
 BIRC3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BIRC3
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 EXP
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    transferase activity GO:0016740 EXP
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IBA
    protein-containing complex binding GO:0044877 IEA
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    apoptotic process GO:0006915 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    canonical NF-kappaB signal transduction GO:0007249 TAS
    spermatogenesis GO:0007283 IEA
    positive regulation of protein ubiquitination GO:0031398 IBA
    positive regulation of protein ubiquitination GO:0031398 IDA
    tumor necrosis factor-mediated signaling pathway GO:0033209 TAS
    regulation of toll-like receptor signaling pathway GO:0034121 TAS
    non-canonical NF-kappaB signal transduction GO:0038061 TAS
    regulation of RIG-I signaling pathway GO:0039535 TAS
    regulation of apoptotic process GO:0042981 IMP
    negative regulation of apoptotic process GO:0043066 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 TAS
    regulation of innate immune response GO:0045088 TAS
    regulation of inflammatory response GO:0050727 TAS
    regulation of cell cycle GO:0051726 IBA
    regulation of necroptotic process GO:0060544 IMP
    regulation of necroptotic process GO:0060544 TAS
    negative regulation of necroptotic process GO:0060546 IBA
    regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0070424 TAS
    regulation of cysteine-type endopeptidase activity GO:2000116 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    protein-containing complex GO:0032991 IEA
 Experiment description of studies that identified BIRC3 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BIRC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEPT4  
Affinity Capture-Western Homo sapiens
2 DZIP3  
Two-hybrid Homo sapiens
3 RIPK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
4 MBTPS1 8720
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
5 BIRC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 ZFAND2A  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 MAVS 57506
Affinity Capture-Western Homo sapiens
8 UBE2N 7334
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 CASP7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 XAF1  
Affinity Capture-Western Homo sapiens
11 XIAP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
13 TNFRSF1B  
Affinity Capture-Western Homo sapiens
14 CFLAR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 HTRA2 27429
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 GSK3B 2932
Affinity Capture-Western Homo sapiens
17 SPHK1 8877
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
18 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
19 EGLN3  
Affinity Capture-Western Homo sapiens
20 LTBR 4055
Affinity Capture-MS Homo sapiens
21 CTBP2 1488
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
22 USP35  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 REL 5966
Affinity Capture-Western Homo sapiens
24 E2F1 1869
Affinity Capture-Western Homo sapiens
25 TNF  
Affinity Capture-Western Homo sapiens
26 IKBKG 8517
Reconstituted Complex Homo sapiens
27 LIMA1 51474
Affinity Capture-Western Homo sapiens
28 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 SNX7 51375
Two-hybrid Homo sapiens
31 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
32 EGFR 1956
Affinity Capture-Western Homo sapiens
33 RCHY1  
Two-hybrid Homo sapiens
34 BCL10  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
35 RIPK1 8737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
36 CYFIP2 26999
Two-hybrid Homo sapiens
37 TRAF3 7187
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 NOD2 64127
Affinity Capture-Western Homo sapiens
39 PACS2 23241
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
40 RIPK3 11035
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
41 DIABLO 56616
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
42 UBE2D2 7322
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 UBE2I 7329
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 UBE2V1 7335
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
45 CASP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 CASP9 842
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
47 IRF5  
Affinity Capture-Western Homo sapiens
48 PELI1 57162
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
49 UBE2L3 7332
Affinity Capture-Western Homo sapiens
50 TLR3  
Affinity Capture-Western Homo sapiens
51 CASP3 836
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
52 CASP8 841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 CASP10  
Affinity Capture-Western Homo sapiens
54 USP19 10869
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
55 CD40LG 959
Affinity Capture-Western Homo sapiens
56 NFKB1 4790
Co-localization Homo sapiens
57 TRIM32 22954
Affinity Capture-Western Homo sapiens
58 RIPK4  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
59 RAF1 5894
Reconstituted Complex Homo sapiens
60 UBE2Q2 92912
Two-hybrid Homo sapiens
61 UBE2D3 7323
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
62 HAX1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
63 SUMO1 7341
Two-hybrid Homo sapiens
64 IKBKB 3551
Co-localization Homo sapiens
65 IRF1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
66 UBE2D1 7321
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
67 IKBKE 9641
Biochemical Activity Homo sapiens
68 UBXN1 51035
Affinity Capture-MS Homo sapiens
69 BIRC5  
Reconstituted Complex Homo sapiens
70 COMMD1 150684
Affinity Capture-Western Homo sapiens
71 TRAF1 7185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
72 BIRC3 330
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
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