Gene description for RIPK1
Gene name receptor (TNFRSF)-interacting serine-threonine kinase 1
Gene symbol RIPK1
Other names/aliases RIP
RIP1
Species Homo sapiens
 Database cross references - RIPK1
ExoCarta ExoCarta_8737
Vesiclepedia VP_8737
Entrez Gene 8737
HGNC 10019
MIM 603453
UniProt Q13546  
 RIPK1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RIPK1
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein kinase activity GO:0004672 IMP
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 IMP
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    JUN kinase kinase kinase activity GO:0004706 IBA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    death receptor binding GO:0005123 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    signaling adaptor activity GO:0035591 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    protein-containing complex binding GO:0044877 IDA
    death domain binding GO:0070513 IPI
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    MAPK cascade GO:0000165 IEA
    positive regulation of protein phosphorylation GO:0001934 IMP
    chromatin remodeling GO:0006338 IEA
    apoptotic process GO:0006915 IMP
    inflammatory response GO:0006954 IEA
    response to oxidative stress GO:0006979 IMP
    positive regulation of gene expression GO:0010628 IDA
    protein catabolic process GO:0030163 IDA
    positive regulation of interleukin-8 production GO:0032757 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IC
    response to tumor necrosis factor GO:0034612 IMP
    intracellular signal transduction GO:0035556 IDA
    peptidyl-serine autophosphorylation GO:0036289 IDA
    peptidyl-serine autophosphorylation GO:0036289 IMP
    positive regulation of apoptotic process GO:0043065 IDA
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of apoptotic process GO:0043066 ISS
    positive regulation of programmed cell death GO:0043068 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    positive regulation of neuron apoptotic process GO:0043525 IEA
    positive regulation of macrophage differentiation GO:0045651 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of JNK cascade GO:0046330 IDA
    protein autophosphorylation GO:0046777 IDA
    protein autophosphorylation GO:0046777 IMP
    positive regulation of inflammatory response GO:0050729 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    positive regulation of necroptotic process GO:0060545 IMP
    negative regulation of necroptotic process GO:0060546 ISS
    positive regulation of programmed necrotic cell death GO:0062100 IMP
    positive regulation of interleukin-6-mediated signaling pathway GO:0070105 IMP
    T cell apoptotic process GO:0070231 ISS
    necroptotic process GO:0070266 IMP
    necroptotic process GO:0070266 ISS
    necroptotic process GO:0070266 TAS
    cellular response to hydrogen peroxide GO:0070301 ISS
    regulation of ATP:ADP antiporter activity GO:0070926 IMP
    cellular response to tumor necrosis factor GO:0071356 IDA
    cellular response to growth factor stimulus GO:0071363 IEA
    extrinsic apoptotic signaling pathway GO:0097191 IDA
    extrinsic apoptotic signaling pathway GO:0097191 IMP
    programmed necrotic cell death GO:0097300 ISS
    ripoptosome assembly GO:0097343 IMP
    necroptotic signaling pathway GO:0097527 IBA
    necroptotic signaling pathway GO:0097527 IMP
    necroptotic signaling pathway GO:0097527 ISS
    positive regulation of execution phase of apoptosis GO:1900119 IEA
    ripoptosome assembly involved in necroptotic process GO:1901026 IEA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IEA
    positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 IEA
    positive regulation of miRNA processing GO:1903800 IDA
    amyloid fibril formation GO:1990000 IMP
    positive regulation of reactive oxygen species metabolic process GO:2000379 TAS
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 TAS
    death-inducing signaling complex GO:0031264 IDA
    protein-containing complex GO:0032991 IDA
    receptor complex GO:0043235 IDA
    ripoptosome GO:0097342 IDA
 Experiment description of studies that identified RIPK1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RIPK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Co-fractionation Homo sapiens
2 TNFAIP3 7128
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 XAF1  
Affinity Capture-Western Homo sapiens
4 ERN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 XIAP  
Reconstituted Complex Homo sapiens
6 NPRL2  
Affinity Capture-MS Homo sapiens
7 BRDT  
Affinity Capture-MS Homo sapiens
8 TNFSF10 8743
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 S100A6 6277
Affinity Capture-MS Homo sapiens
10 SERPINB6 5269
Affinity Capture-MS Homo sapiens
11 TRADD 8717
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 RNMT 8731
Co-fractionation Homo sapiens
13 UBC 7316
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 RIPK1 8737
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
15 THSD4 79875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PPDPF  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 RFFL 117584
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 RIPK3 11035
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
19 WDR48 57599
Affinity Capture-Western Homo sapiens
20 TRIM28 10155
Affinity Capture-Western Homo sapiens
21 CNOT10 25904
Affinity Capture-MS Homo sapiens
22 PELI1 57162
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 MAP3K7  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 TLR3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 D2HGDH 728294
Affinity Capture-MS Homo sapiens
26 NUMBL 9253
Two-hybrid Homo sapiens
27 CDC42BPB 9578
Two-hybrid Homo sapiens
28 CRADD  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
29 MAP3K3 4215
Affinity Capture-Western Homo sapiens
30 HERC2 8924
Affinity Capture-MS Homo sapiens
31 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 ATG7 10533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 BIRC3 330
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 OPTN 10133
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 RIPK2  
Affinity Capture-Western Homo sapiens
36 USP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
37 TNFRSF1B  
Affinity Capture-Western Homo sapiens
38 CFLAR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 RNF11 26994
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 FAS 355
Two-hybrid Homo sapiens
41 TNF  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 USP21  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
43 B4GALT2  
Affinity Capture-MS Homo sapiens
44 NOD2 64127
Affinity Capture-Western Homo sapiens
45 RCCD1  
Affinity Capture-MS Homo sapiens
46 TRIM21 6737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 TGM5  
Affinity Capture-MS Homo sapiens
49 ZFP91 80829
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 KRT2 3849
Affinity Capture-MS Homo sapiens
51 ITCH 83737
Affinity Capture-Western Homo sapiens
52 HSPB8 26353
Affinity Capture-MS Homo sapiens
53 CYLD  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 USP27X  
Affinity Capture-Western Homo sapiens
55 YOD1  
Biochemical Activity Homo sapiens
56 PSG11  
Affinity Capture-MS Homo sapiens
57 BIRC2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 PRKCZ 5590
Affinity Capture-Western Homo sapiens
59 UBE2N 7334
Biochemical Activity Homo sapiens
60 DCTN3 11258
Affinity Capture-MS Homo sapiens
61 RXRA 6256
Co-fractionation Homo sapiens
62 USP4 7375
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 TAX1BP1 8887
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 OTUD1 220213
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
65 XPO1 7514
Affinity Capture-MS Homo sapiens
66 EGLN3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 HERC2P9  
Affinity Capture-MS Homo sapiens
68 ANXA1 301
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 NTAN1 123803
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
71 TRAF6 7189
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
72 DAB2IP 153090
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 EGFR 1956
Affinity Capture-Western Homo sapiens
74 METTL21B  
Affinity Capture-MS Homo sapiens
75 DUSP16  
Affinity Capture-MS Homo sapiens
76 TRAF3 7187
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
77 CCDC50 152137
Affinity Capture-Western Homo sapiens
78 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 ABTB2 25841
Affinity Capture-MS Homo sapiens
80 C22orf29  
Affinity Capture-MS Homo sapiens
81 TRAF5  
Affinity Capture-Western Homo sapiens
82 TRIM27  
Affinity Capture-Western Homo sapiens
83 ITGB4 3691
Co-fractionation Homo sapiens
84 HSPA1A 3303
Affinity Capture-MS Homo sapiens
85 AP1M2 10053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 PARP1 142
Proximity Label-MS Homo sapiens
87 RNF216  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
88 CHUK 1147
Co-fractionation Homo sapiens
89 TICAM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 MLKL 197259
Affinity Capture-Western Homo sapiens
91 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 MAP3K14  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 FADD 8772
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
94 RARA 5914
Affinity Capture-Western Homo sapiens
95 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 PRKY  
Affinity Capture-MS Homo sapiens
97 TNFRSF25  
Affinity Capture-Western Homo sapiens
98 USP1 7398
Affinity Capture-Western Homo sapiens
99 PYCARD 29108
Affinity Capture-Western Homo sapiens
100 RNF31 55072
Affinity Capture-Western Homo sapiens
101 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
102 CASP8 841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
103 PIDD1  
Affinity Capture-Western Homo sapiens
104 SQSTM1 8878
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
105 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
106 CASP10  
Affinity Capture-Western Homo sapiens
107 TNFRSF10B 8795
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
108 DHFR 1719
Affinity Capture-MS Homo sapiens
109 ANKRD13A 88455
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
110 INF2 64423
Affinity Capture-MS Homo sapiens
111 LRRK2 120892
Affinity Capture-Western Homo sapiens
112 RAPGEF5  
Affinity Capture-MS Homo sapiens
113 MIB2 142678
Affinity Capture-Western Homo sapiens
114 UBXN6 80700
Affinity Capture-MS Homo sapiens
115 CCDC96  
Affinity Capture-MS Homo sapiens
116 GPX7 2882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 IKBKB 3551
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
118 RBCK1  
Affinity Capture-Western Homo sapiens
119 CLIP3  
Affinity Capture-Western Homo sapiens
120 C19orf80  
Affinity Capture-Western Homo sapiens
121 TRPC4AP  
Affinity Capture-Western Homo sapiens
122 TRAF1 7185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RIPK1 is involved
PathwayEvidenceSource
Apoptosis TAS Reactome
CASP8 activity is inhibited TAS Reactome
Caspase activation via Death Receptors in the presence of ligand TAS Reactome
Caspase activation via extrinsic apoptotic signalling pathway TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Defective RIPK1-mediated regulated necrosis TAS Reactome
Deubiquitination TAS Reactome
Dimerization of procaspase-8 TAS Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Ion channel transport TAS Reactome
Metabolism of proteins TAS Reactome
Microbial modulation of RIPK1-mediated regulated necrosis TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TAS Reactome
Ovarian tumor domain proteases TAS Reactome
Post-translational protein modification TAS Reactome
Potential therapeutics for SARS TAS Reactome
Programmed Cell Death TAS Reactome
Regulated Necrosis TAS Reactome
Regulation by c-FLIP TAS Reactome
Regulation of necroptotic cell death TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
RIP-mediated NFkB activation via ZBP1 TAS Reactome
RIPK1-mediated regulated necrosis TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
SARS-CoV-1-mediated effects on programmed cell death TAS Reactome
Signal Transduction TAS Reactome
Stimuli-sensing channels TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TLR3-mediated TICAM1-dependent programmed cell death TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
TNFR1-induced proapoptotic signaling TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
Transport of small molecules TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
TRIF-mediated programmed cell death TAS Reactome
TRP channels TAS Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs TAS Reactome





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