Gene description for USP4
Gene name ubiquitin specific peptidase 4 (proto-oncogene)
Gene symbol USP4
Other names/aliases UNP
Species Homo sapiens
 Database cross references - USP4
ExoCarta ExoCarta_7375
Entrez Gene 7375
HGNC 12627
MIM 603486
UniProt Q13107  
 USP4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for USP4
Molecular Function
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    adenosine receptor binding GO:0031685 IPI
    cysteine-type endopeptidase activity GO:0004197 IBA
    metal ion binding GO:0046872 IEA
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    spliceosomal tri-snRNP complex assembly GO:0000244 IMP
    protein deubiquitination GO:0016579 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    negative regulation of protein ubiquitination GO:0031397 IMP
    regulation of protein stability GO:0031647 IDA
    protein localization to cell surface GO:0034394 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    lysosome GO:0005764 TAS
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified USP4 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOLC1 9221
Invivo Homo sapiens
2 RBL1  
Invitro Homo sapiens
Invivo Homo sapiens
3 TP53BP2  
Two-hybrid Homo sapiens
4 TRIM21 6737
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which USP4 is involved
TNFR1-mediated proapoptotic signaling TAS Reactome

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