Gene description for SFN
Gene name stratifin
Gene symbol SFN
Other names/aliases YWHAS
Species Homo sapiens
 Database cross references - SFN
ExoCarta ExoCarta_2810
Vesiclepedia VP_2810
Entrez Gene 2810
HGNC 10773
MIM 601290
UniProt P31947  
 SFN identified in sEVs derived from the following tissue/cell type
Bladder cancer cells 20224111    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 19837982    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Keratinocytes 18452139    
Keratinocytes 19530224    
Keratinocytes 19530224    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells Unpublished / Not applicable
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
Urine 15326289    
Urine 19056867    
Urine 21595033    
Urine 21595033    
Urine 21595033    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SFN
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase C inhibitor activity GO:0008426 TAS
    protein kinase binding GO:0019901 IBA
    identical protein binding GO:0042802 IPI
    cadherin binding GO:0045296 HDA
    phosphoserine residue binding GO:0050815 IDA
    protein sequestering activity GO:0140311 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    release of cytochrome c from mitochondria GO:0001836 IDA
    keratinocyte development GO:0003334 IEA
    negative regulation of protein kinase activity GO:0006469 TAS
    protein export from nucleus GO:0006611 IEA
    signal transduction GO:0007165 IBA
    protein localization GO:0008104 IBA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IDA
    regulation of epidermal cell division GO:0010482 ISS
    negative regulation of keratinocyte proliferation GO:0010839 IEA
    regulation of cell-cell adhesion GO:0022407 IMP
    positive regulation of cell growth GO:0030307 IEA
    keratinization GO:0031424 IEA
    regulation of protein localization GO:0032880 IMP
    keratinocyte proliferation GO:0043616 IEA
    positive regulation of epidermal cell differentiation GO:0045606 ISS
    positive regulation of cell adhesion GO:0045785 IMP
    negative regulation of innate immune response GO:0045824 IDA
    positive regulation of protein export from nucleus GO:0046827 IEA
    regulation of cell cycle GO:0051726 IEA
    establishment of skin barrier GO:0061436 ISS
    stem cell proliferation GO:0072089 IEA
    cAMP/PKA signal transduction GO:0141156 IEA
    negative regulation of protein localization to plasma membrane GO:1903077 IMP
    positive regulation of protein localization GO:1903829 IMP
    negative regulation of stem cell proliferation GO:2000647 IEA
Subcellular Localization
    extracellular space GO:0005615 TAS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SFN in sEVs
1
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
4
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
7
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
11
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 32
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70|LAMP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 18452139    
Organism Homo sapiens
Experiment description Primary human keratinocytes externalize stratifin protein via exosomes.
Authors "RChavez-Muñoz C, Morse J, Kilani R, Ghahary A"
Journal name JCB
Publication year 2008
Sample Keratinocytes
Sample name Keratinocytes
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
21
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
22
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
23
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
26
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
28
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
35
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
38
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
42
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
43
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
44
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
45
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
46
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
47
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
48
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
49
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
50
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
51
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
52
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
53
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
54
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SFN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ISG15 9636
Affinity Capture-Western Homo sapiens
2 KRT1 3848
Affinity Capture-MS Homo sapiens
3 RALGPS2 55103
Affinity Capture-MS Homo sapiens
4 NFIB  
Reconstituted Complex Homo sapiens
5 EIF3C 8663
Affinity Capture-MS Homo sapiens
6 SH3BP4 23677
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 PPP1R3D  
Affinity Capture-MS Homo sapiens
8 CRK 1398
Affinity Capture-MS Homo sapiens
9 PLEKHF2 79666
Two-hybrid Homo sapiens
10 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
11 HDAC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SOX2  
Affinity Capture-MS Homo sapiens
13 GRB7 2886
Affinity Capture-MS Homo sapiens
14 ABLIM1 3983
Affinity Capture-MS Homo sapiens
15 RHPN2 85415
Affinity Capture-MS Homo sapiens
16 HSPH1 10808
Co-fractionation Homo sapiens
17 RPS9 6203
Affinity Capture-MS Homo sapiens
18 FAM86C1  
Affinity Capture-MS Homo sapiens
19 SFN 2810
FRET Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
20 NSFL1C 55968
Co-fractionation Homo sapiens
21 RNF126  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
22 RPS11 6205
Affinity Capture-MS Homo sapiens
23 EEF1A1 1915
Far Western Homo sapiens
24 FAM163A  
Affinity Capture-MS Homo sapiens
25 RBMX 27316
Co-fractionation Homo sapiens
26 CHMP4C 92421
Affinity Capture-MS Homo sapiens
27 DPP8 54878
Co-fractionation Homo sapiens
28 MAP3K2 10746
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PKP2 5318
Affinity Capture-MS Homo sapiens
30 MAP1B 4131
Affinity Capture-MS Homo sapiens
31 HDAC7  
Affinity Capture-MS Homo sapiens
32 PABPC1 26986
Co-fractionation Homo sapiens
33 SMTNL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 YAP1 10413
Affinity Capture-MS Homo sapiens
35 TRIM21 6737
Affinity Capture-MS Homo sapiens
36 PIGT 51604
Affinity Capture-MS Homo sapiens
37 ARHGAP11A  
Affinity Capture-MS Homo sapiens
38 DTX2 113878
Affinity Capture-MS Homo sapiens
39 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
40 SHCBP1 79801
Affinity Capture-MS Homo sapiens
41 MAGEB2 4113
Affinity Capture-MS Homo sapiens
42 DDX39B 7919
Affinity Capture-MS Homo sapiens
43 ST5 6764
Affinity Capture-MS Homo sapiens
44 WDYHV1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
45 IGBP1 3476
Co-fractionation Homo sapiens
46 YWHAE 7531
Co-fractionation Homo sapiens
47 EIF3G 8666
Affinity Capture-MS Homo sapiens
48 HSPA5 3309
Co-fractionation Homo sapiens
49 ARHGAP32  
Affinity Capture-MS Homo sapiens
50 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
51 AGPAT1 10554
Affinity Capture-MS Homo sapiens
52 LRRC59 55379
Affinity Capture-MS Homo sapiens
53 SRSF4 6429
Affinity Capture-MS Homo sapiens
54 LMO7 4008
Affinity Capture-MS Homo sapiens
55 YWHAZ 7534
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
56 PIK3C2B 5287
Affinity Capture-MS Homo sapiens
57 FAM122B  
Affinity Capture-MS Homo sapiens
58 TJP2 9414
Affinity Capture-MS Homo sapiens
59 RPA3 6119
Proximity Label-MS Homo sapiens
60 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 SUPT16H 11198
Affinity Capture-MS Homo sapiens
62 RRAGC 64121
Co-fractionation Homo sapiens
63 SRSF8 10929
Affinity Capture-MS Homo sapiens
64 RPS16 6217
Affinity Capture-MS Homo sapiens
65 CDC25A  
Affinity Capture-MS Homo sapiens
66 BAD  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
67 CHTOP  
Affinity Capture-MS Homo sapiens
68 PLEC 5339
Affinity Capture-MS Homo sapiens
69 RBM25 58517
Affinity Capture-MS Homo sapiens
70 EIF3I 8668
Affinity Capture-MS Homo sapiens
71 RUVBL2 10856
Co-fractionation Homo sapiens
72 IRS2 8660
Affinity Capture-MS Homo sapiens
73 RBM39 9584
Affinity Capture-MS Homo sapiens
74 PTPN2 5771
Affinity Capture-MS Homo sapiens
75 TKT 7086
Cross-Linking-MS (XL-MS) Homo sapiens
76 TBL3 10607
Two-hybrid Homo sapiens
77 G3BP2 9908
Affinity Capture-MS Homo sapiens
78 PPP1R2 5504
Co-fractionation Homo sapiens
79 EIF4B 1975
Co-fractionation Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
80 MARK1 4139
Affinity Capture-MS Homo sapiens
81 RPL23A 6147
Affinity Capture-MS Homo sapiens
82 NFIC 4782
Reconstituted Complex Homo sapiens
83 PLD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 KIF23 9493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 KLC2 64837
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
86 EXO1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
87 TARDBP 23435
Affinity Capture-MS Homo sapiens
88 RPA2 6118
Proximity Label-MS Homo sapiens
89 MKRN3  
Two-hybrid Homo sapiens
90 APC  
Affinity Capture-MS Homo sapiens
91 SRSF2 6427
Affinity Capture-MS Homo sapiens
92 SNRPF 6636
Co-fractionation Homo sapiens
93 CCDC102B  
Two-hybrid Homo sapiens
94 RPS3 6188
Affinity Capture-MS Homo sapiens
95 RPS18 6222
Affinity Capture-MS Homo sapiens
96 PGK1 5230
Co-fractionation Homo sapiens
97 TNK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 FAM53B  
Affinity Capture-MS Homo sapiens
99 COPS6 10980
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
100 OSBP 5007
Co-fractionation Homo sapiens
101 IPO5 3843
Co-fractionation Homo sapiens
102 SRRM2 23524
Affinity Capture-MS Homo sapiens
103 RECQL4  
Affinity Capture-MS Homo sapiens
104 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
105 TRIM25 7706
Affinity Capture-Western Homo sapiens
106 USP7 7874
Co-fractionation Homo sapiens
107 YWHAB 7529
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
108 PTPN3  
Affinity Capture-MS Homo sapiens
109 CDCA7  
Affinity Capture-MS Homo sapiens
110 ACTA2 59
Affinity Capture-MS Homo sapiens
111 ISCU 23479
Affinity Capture-MS Homo sapiens
112 KLHDC2  
Affinity Capture-MS Homo sapiens
113 RPL4 6124
Affinity Capture-MS Homo sapiens
114 KLC1 3831
Affinity Capture-MS Homo sapiens
115 DRG1 4733
Affinity Capture-MS Homo sapiens
116 CDR2L  
Affinity Capture-MS Homo sapiens
117 RNF115  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
118 NFIA 4774
Reconstituted Complex Homo sapiens
119 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
120 DCAF7 10238
Affinity Capture-MS Homo sapiens
121 LUC7L2 51631
Affinity Capture-MS Homo sapiens
122 CHST1 8534
Two-hybrid Homo sapiens
123 HNRNPD 3184
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
124 CASP14 23581
Affinity Capture-MS Homo sapiens
125 PTOV1  
Affinity Capture-MS Homo sapiens
126 USP4 7375
Affinity Capture-Western Homo sapiens
127 SYNJ2 8871
Affinity Capture-MS Homo sapiens
128 RPS2 6187
Affinity Capture-MS Homo sapiens
129 JADE1  
Affinity Capture-MS Homo sapiens
130 POLD1 5424
Affinity Capture-MS Homo sapiens
131 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
132 KIAA0930  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 LGALS7 3963
Affinity Capture-MS Homo sapiens
134 WEE1 7465
Affinity Capture-MS Homo sapiens
135 SPTBN1 6711
Co-fractionation Homo sapiens
136 G6PD 2539
Co-fractionation Homo sapiens
137 ARHGEF5  
Affinity Capture-MS Homo sapiens
138 BLMH 642
Affinity Capture-MS Homo sapiens
139 MET 4233
Affinity Capture-Western Homo sapiens
140 MPRIP 23164
Affinity Capture-MS Homo sapiens
141 RPL26 6154
Affinity Capture-MS Homo sapiens
142 RAE1 8480
Affinity Capture-MS Homo sapiens
143 EIF3H 8667
Affinity Capture-MS Homo sapiens
144 RPL13 6137
Affinity Capture-MS Homo sapiens
145 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
146 SLK 9748
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
147 RFWD2  
Biochemical Activity Homo sapiens
148 SH2D3A  
Affinity Capture-MS Homo sapiens
149 SPIRE1 56907
Affinity Capture-MS Homo sapiens
150 SIPA1L3  
Affinity Capture-MS Homo sapiens
151 AJUBA  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
152 OXSR1 9943
Affinity Capture-MS Homo sapiens
153 CDK1 983
Affinity Capture-Western Homo sapiens
154 Herc2  
Affinity Capture-MS Mus musculus
155 TRIP12 9320
Co-fractionation Homo sapiens
156 OSBPL3 26031
Affinity Capture-MS Homo sapiens
157 DHFR 1719
Affinity Capture-MS Homo sapiens
158 CALML5 51806
Affinity Capture-MS Homo sapiens
159 ERRFI1 54206
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
160 RPL7A 6130
Affinity Capture-MS Homo sapiens
161 GOT1 2805
Affinity Capture-MS Homo sapiens
162 BANP  
Affinity Capture-MS Homo sapiens
163 KRAS 3845
Affinity Capture-MS Homo sapiens
164 MAGI1  
Affinity Capture-MS Homo sapiens
165 RPSA 3921
Affinity Capture-MS Homo sapiens
166 KIF1B 23095
Co-fractionation Homo sapiens
167 CTPS2 56474
Co-fractionation Homo sapiens
168 PARD3 56288
Affinity Capture-MS Homo sapiens
169 FAM9B  
Two-hybrid Homo sapiens
170 PAK2 5062
Co-fractionation Homo sapiens
171 MAGEA1  
Two-hybrid Homo sapiens
172 RPS19 6223
Affinity Capture-MS Homo sapiens
173 LAD1 3898
Affinity Capture-MS Homo sapiens
174 RANBP3 8498
Affinity Capture-MS Homo sapiens
175 CBY1  
Affinity Capture-Western Homo sapiens
176 ANKS1A 23294
Affinity Capture-MS Homo sapiens
177 FOXO4  
Two-hybrid Homo sapiens
178 SORBS2  
Affinity Capture-MS Homo sapiens
179 KAT7  
Affinity Capture-MS Homo sapiens
180 TRIM28 10155
Co-fractionation Homo sapiens
181 PAK4 10298
Affinity Capture-MS Homo sapiens
182 MCM2 4171
Affinity Capture-MS Homo sapiens
183 ZNF638 27332
Affinity Capture-MS Homo sapiens
184 RAB3IP  
Two-hybrid Homo sapiens
185 CYR61 3491
Affinity Capture-MS Homo sapiens
186 PRDX4 10549
Co-fractionation Homo sapiens
187 TNS4 84951
Affinity Capture-MS Homo sapiens
188 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
189 EEA1 8411
Co-localization Homo sapiens
190 PSME3 10197
Co-fractionation Homo sapiens
191 UBE2V1 7335
Co-fractionation Homo sapiens
192 LONRF1  
Two-hybrid Homo sapiens
193 BCAR1 9564
Affinity Capture-MS Homo sapiens
194 RPS10 6204
Co-fractionation Homo sapiens
195 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
196 USP8 9101
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
197 DEK 7913
Affinity Capture-MS Homo sapiens
198 NTRK1 4914
Affinity Capture-MS Homo sapiens
199 ARNT 405
Affinity Capture-MS Homo sapiens
200 CDH1 999
Proximity Label-MS Homo sapiens
201 SNRPN 6638
Affinity Capture-MS Homo sapiens
202 ACTG1 71
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
203 IPO9 55705
Co-fractionation Homo sapiens
204 LARP1 23367
Co-fractionation Homo sapiens
205 ZAK 51776
Affinity Capture-MS Homo sapiens
206 SIK3 23387
Affinity Capture-MS Homo sapiens
207 MYCBP2 23077
Affinity Capture-MS Homo sapiens
208 CDC73  
Affinity Capture-MS Homo sapiens
209 MARK3 4140
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
210 SHROOM3 57619
Affinity Capture-MS Homo sapiens
211 HDAC9  
Affinity Capture-Western Homo sapiens
212 NR3C1 2908
Two-hybrid Homo sapiens
213 H1F0 3005
Affinity Capture-MS Homo sapiens
214 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
215 CYFIP2 26999
Co-fractionation Homo sapiens
216 ZFYVE19 84936
Co-fractionation Homo sapiens
217 SERPINB5 5268
Affinity Capture-MS Homo sapiens
218 DMTN  
Affinity Capture-MS Homo sapiens
219 NRBP1 29959
Co-fractionation Homo sapiens
220 RPS13 6207
Affinity Capture-MS Homo sapiens
221 SAV1  
Affinity Capture-MS Homo sapiens
222 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
223 TP63  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
224 CGN  
Affinity Capture-MS Homo sapiens
225 RAF1 5894
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
226 RPL18 6141
Affinity Capture-MS Homo sapiens
227 ARAF 369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 NEDD4L 23327
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
229 EIF2S1 1965
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
230 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
231 RPS25 6230
Affinity Capture-MS Homo sapiens
232 IMPDH2 3615
Affinity Capture-MS Homo sapiens
233 RPS21 6227
Affinity Capture-MS Homo sapiens
234 LSR 51599
Affinity Capture-MS Homo sapiens
235 KRT10 3858
Affinity Capture-MS Homo sapiens
236 SNRPA 6626
Affinity Capture-MS Homo sapiens
237 HNRNPM 4670
Affinity Capture-MS Homo sapiens
238 G3BP1 10146
Affinity Capture-MS Homo sapiens
239 CYTH2 9266
Affinity Capture-MS Homo sapiens
240 PPFIBP2 8495
Affinity Capture-MS Homo sapiens
241 RPL34 6164
Affinity Capture-MS Homo sapiens
242 ACTA1 58
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
243 RPL38 6169
Affinity Capture-MS Homo sapiens
244 LRRK2 120892
Reconstituted Complex Homo sapiens
245 PMVK 10654
Affinity Capture-MS Homo sapiens
246 RPL8 6132
Affinity Capture-MS Homo sapiens
247 SERBP1 26135
Affinity Capture-MS Homo sapiens
248 CCR1  
Affinity Capture-MS Homo sapiens
249 UBE2H 7328
Affinity Capture-MS Homo sapiens
250 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
251 PARD3B 117583
Affinity Capture-MS Homo sapiens
252 CCNH  
Two-hybrid Homo sapiens
253 RPS3A 6189
Affinity Capture-MS Homo sapiens
254 PPIE 10450
Affinity Capture-MS Homo sapiens
255 RACGAP1 29127
Affinity Capture-MS Homo sapiens
256 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
257 SUB1 10923
Affinity Capture-MS Homo sapiens
258 RPL10 6134
Affinity Capture-MS Homo sapiens
259 HIST1H2BB 3018
Affinity Capture-MS Homo sapiens
260 SASH1 23328
Affinity Capture-MS Homo sapiens
261 TRIM62  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
262 PRR5  
Affinity Capture-MS Homo sapiens
263 DTL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
264 GSK3A 2931
Affinity Capture-MS Homo sapiens
265 CTSD 1509
Affinity Capture-MS Homo sapiens
266 RNH1 6050
Co-fractionation Homo sapiens
267 RPS20 6224
Affinity Capture-MS Homo sapiens
268 MARK2 2011
Affinity Capture-MS Homo sapiens
269 RPL24 6152
Affinity Capture-MS Homo sapiens
270 DYRK1A 1859
Affinity Capture-MS Homo sapiens
271 KIF5B 3799
Affinity Capture-MS Homo sapiens
272 PLK4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
273 FBXW7  
Affinity Capture-MS Homo sapiens
274 COL4A3BP 10087
Affinity Capture-MS Homo sapiens
275 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
276 EIF5B 9669
Affinity Capture-MS Homo sapiens
277 ESR1  
Affinity Capture-MS Homo sapiens
278 PPP1CA 5499
Co-fractionation Homo sapiens
279 PPIB 5479
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
280 HSP90B1 7184
Co-fractionation Homo sapiens
281 NONO 4841
Affinity Capture-MS Homo sapiens
282 ATF2  
Affinity Capture-MS Homo sapiens
283 APLP2 334
Affinity Capture-MS Homo sapiens
284 VCL 7414
Co-fractionation Homo sapiens
285 VCP 7415
Affinity Capture-MS Homo sapiens
286 DDX5 1655
Affinity Capture-MS Homo sapiens
287 GPRIN2  
Two-hybrid Homo sapiens
288 CHEK1  
Affinity Capture-Western Homo sapiens
289 PI4KB 5298
Affinity Capture-MS Homo sapiens
290 TRIM32 22954
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
291 RPL27A 6157
Affinity Capture-MS Homo sapiens
292 KRT2 3849
Affinity Capture-MS Homo sapiens
293 MYH11 4629
Affinity Capture-MS Homo sapiens
294 BRAF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
295 ITCH 83737
Affinity Capture-MS Homo sapiens
296 RPS15A 6210
Affinity Capture-MS Homo sapiens
297 CAMKK2 10645
Affinity Capture-MS Homo sapiens
298 ST13 6767
Co-fractionation Homo sapiens
299 DNAJC7 7266
Co-fractionation Homo sapiens
300 ACTN1 87
Co-fractionation Homo sapiens
301 GAN 8139
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
302 SFPQ 6421
Affinity Capture-MS Homo sapiens
303 SERPINB3 6317
Affinity Capture-MS Homo sapiens
304 TAF15 8148
Affinity Capture-MS Homo sapiens
305 IVL 3713
Affinity Capture-MS Homo sapiens
306 FANCD2  
Affinity Capture-MS Homo sapiens
307 EIF4G1 1981
Co-fractionation Homo sapiens
308 RPL35 11224
Affinity Capture-MS Homo sapiens
309 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
310 SRSF1 6426
Affinity Capture-MS Homo sapiens
311 RPS6 6194
Affinity Capture-MS Homo sapiens
312 RND3 390
Affinity Capture-MS Homo sapiens
313 DKC1 1736
Affinity Capture-MS Homo sapiens
314 TXNL1 9352
Co-fractionation Homo sapiens
315 RPAP3 79657
Co-fractionation Homo sapiens
316 PPFIBP1 8496
Affinity Capture-MS Homo sapiens
317 SRSF10 10772
Affinity Capture-MS Homo sapiens
318 CLTC 1213
Co-fractionation Homo sapiens
319 MDM4  
Affinity Capture-Western Homo sapiens
320 ZC2HC1C  
Two-hybrid Homo sapiens
321 PPFIA1 8500
Co-fractionation Homo sapiens
322 CCDC125 202243
Two-hybrid Homo sapiens
323 C9orf72  
Affinity Capture-MS Homo sapiens
324 MDM2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
325 UBE2R2 54926
Co-fractionation Homo sapiens
326 PKP3 11187
Affinity Capture-MS Homo sapiens
327 DHX15 1665
Affinity Capture-MS Homo sapiens
328 SPTAN1 6709
Co-fractionation Homo sapiens
329 FAM53C 51307
Two-hybrid Homo sapiens
330 SAP130  
Co-fractionation Homo sapiens
331 SAP18 10284
Affinity Capture-MS Homo sapiens
332 DUXAP9  
Protein-RNA Homo sapiens
333 MAPRE2 10982
Affinity Capture-MS Homo sapiens
334 SAMSN1  
Reconstituted Complex Homo sapiens
335 PAX9  
Two-hybrid Homo sapiens
336 ING1  
Reconstituted Complex Homo sapiens
337 RPS8 6202
Affinity Capture-MS Homo sapiens
338 FAM189A2  
Two-hybrid Homo sapiens
339 HNRNPU 3192
Affinity Capture-MS Homo sapiens
340 GNB2L1 10399
Affinity Capture-MS Homo sapiens
341 IRS1 3667
Affinity Capture-MS Homo sapiens
342 KIAA0408  
Two-hybrid Homo sapiens
343 RPL17 6139
Affinity Capture-MS Homo sapiens
344 POF1B 79983
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SFN is involved
PathwayEvidenceSource
Activation of BAD and translocation to mitochondria TAS Reactome
Activation of BH3-only proteins TAS Reactome
Apoptosis TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex TAS Reactome
Disease TAS Reactome
FOXO-mediated transcription TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Infectious disease TAS Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
Membrane Trafficking IEA Reactome
Programmed Cell Death TAS Reactome
Regulation of localization of FOXO transcription factors TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase II Transcription TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1 targets host intracellular signalling and regulatory pathways TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2 targets host intracellular signalling and regulatory pathways TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
TP53 Regulates Metabolic Genes TAS Reactome
TP53 Regulates Transcription of Cell Cycle Genes TAS Reactome
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane IEA Reactome
Vesicle-mediated transport IEA Reactome
Viral Infection Pathways TAS Reactome





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