Gene description for IVL
Gene name involucrin
Gene symbol IVL
Other names/aliases -
Species Homo sapiens
 Database cross references - IVL
ExoCarta ExoCarta_3713
Vesiclepedia VP_3713
Entrez Gene 3713
HGNC 6187
MIM 147360
UniProt P07476  
 IVL identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Saliva 19199708    
 Gene ontology annotations for IVL
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    response to UV-B GO:0010224 IDA
    peptide cross-linking GO:0018149 IDA
    isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine GO:0018153 TAS
    keratinocyte differentiation GO:0030216 IDA
    keratinization GO:0031424 IEA
Subcellular Localization
    cornified envelope GO:0001533 IDA
    cornified envelope GO:0001533 TAS
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear body GO:0016604 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified IVL in exosomes
1
Experiment ID 189
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
MISEV standards
EM
Biophysical techniques
HSC70
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for IVL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 BPHL 670
Affinity Capture-MS Homo sapiens
3 KRT1 3848
Reconstituted Complex Homo sapiens
4 POT1  
Two-hybrid Homo sapiens
5 NRSN1  
Affinity Capture-MS Homo sapiens
6 RNF25 64320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CSTA 1475
Reconstituted Complex Homo sapiens
9 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPS2P32  
Affinity Capture-MS Homo sapiens
11 ST7  
Affinity Capture-MS Homo sapiens
12 FNDC5  
Affinity Capture-MS Homo sapiens
13 PI4KA 5297
Affinity Capture-MS Homo sapiens
14 HSF2  
Affinity Capture-MS Homo sapiens
15 KAT7  
Affinity Capture-MS Homo sapiens
16 DPPA4  
Affinity Capture-MS Homo sapiens
17 L2HGDH  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ZDHHC6  
Affinity Capture-MS Homo sapiens
19 ZDHHC19  
Affinity Capture-MS Homo sapiens
20 NUDT3 11165
Affinity Capture-MS Homo sapiens
21 POU3F3  
Affinity Capture-MS Homo sapiens
22 OR13C3  
Affinity Capture-MS Homo sapiens
23 UGT1A10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 LIAS  
Affinity Capture-MS Homo sapiens
25 UCHL5 51377
Reconstituted Complex Homo sapiens
26 PHF11 51131
Affinity Capture-MS Homo sapiens
27 FNDC1 84624
Affinity Capture-MS Homo sapiens
28 SFN 2810
Affinity Capture-MS Homo sapiens
29 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 C18orf21  
Affinity Capture-MS Homo sapiens
31 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ACTA2 59
Affinity Capture-MS Homo sapiens
34 ZNF550  
Affinity Capture-MS Homo sapiens
35 FMNL2 114793
Affinity Capture-MS Homo sapiens
36 POF1B 79983
Affinity Capture-MS Homo sapiens
37 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
38 LRRC10  
Affinity Capture-MS Homo sapiens
39 EIF2B5 8893
Affinity Capture-MS Homo sapiens
40 CERS3  
Affinity Capture-MS Homo sapiens
41 RNF115  
Affinity Capture-MS Homo sapiens
42 SRRT 51593
Affinity Capture-MS Homo sapiens
43 GID8 54994
Affinity Capture-MS Homo sapiens
44 SLC37A4 2542
Affinity Capture-MS Homo sapiens
45 CDH1 999
Proximity Label-MS Homo sapiens
46 TRIM21 6737
Affinity Capture-MS Homo sapiens
47 SARAF  
Affinity Capture-MS Homo sapiens
48 PIGT 51604
Affinity Capture-MS Homo sapiens
49 SSUH2  
Affinity Capture-MS Homo sapiens
50 MBD4  
Affinity Capture-MS Homo sapiens
51 HCN1  
Affinity Capture-MS Homo sapiens
52 UPK1A 11045
Affinity Capture-MS Homo sapiens
53 DKK2  
Affinity Capture-MS Homo sapiens
54 FSTL1 11167
Affinity Capture-MS Homo sapiens
55 ACD  
Two-hybrid Homo sapiens
56 CHMP3 51652
Affinity Capture-MS Homo sapiens
57 CASP14 23581
Affinity Capture-MS Homo sapiens
58 RHBDD1 84236
Affinity Capture-MS Homo sapiens
59 SERPINB3 6317
Affinity Capture-MS Homo sapiens
60 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
61 IVL 3713
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
62 FANCD2  
Affinity Capture-MS Homo sapiens
63 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
64 AGPAT1 10554
Affinity Capture-MS Homo sapiens
65 ZFPL1 7542
Affinity Capture-MS Homo sapiens
66 NT5C1A  
Affinity Capture-MS Homo sapiens
67 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 FAM60A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 JADE1  
Affinity Capture-MS Homo sapiens
71 SLC35F2 54733
Affinity Capture-MS Homo sapiens
72 HDAC9  
Affinity Capture-MS Homo sapiens
73 PCP4  
Affinity Capture-MS Homo sapiens
74 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 ZC3HC1  
Affinity Capture-MS Homo sapiens
77 ELAC2 60528
Affinity Capture-MS Homo sapiens
78 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
79 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 LOR  
Reconstituted Complex Homo sapiens
81 LGALS7 3963
Affinity Capture-MS Homo sapiens
82 CORO1C 23603
Affinity Capture-MS Homo sapiens
83 SERPINB5 5268
Affinity Capture-MS Homo sapiens
84 SUSD3 203328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 PI4KAP1  
Affinity Capture-MS Homo sapiens
87 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 BLMH 642
Affinity Capture-MS Homo sapiens
89 EEF1A2 1917
Affinity Capture-MS Homo sapiens
90 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 ANKRD36B  
Affinity Capture-MS Homo sapiens
92 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 MPI 4351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 FAM213A 84293
Affinity Capture-MS Homo sapiens
95 STX17 55014
Affinity Capture-MS Homo sapiens
96 RIPPLY3  
Affinity Capture-MS Homo sapiens
97 DSP 1832
Reconstituted Complex Homo sapiens
98 RANBP3 8498
Affinity Capture-MS Homo sapiens
99 SLC25A6 293
Affinity Capture-MS Homo sapiens
100 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 WWOX 51741
Affinity Capture-MS Homo sapiens
102 SH2D3A  
Affinity Capture-MS Homo sapiens
103 CTSD 1509
Affinity Capture-MS Homo sapiens
104 CCR1  
Affinity Capture-MS Homo sapiens
105 NHLRC2 374354
Affinity Capture-MS Homo sapiens
106 C1orf35  
Affinity Capture-MS Homo sapiens
107 SSBP2  
Affinity Capture-MS Homo sapiens
108 PTDSS1 9791
Affinity Capture-MS Homo sapiens
109 PKP1 5317
Affinity Capture-MS Homo sapiens
110 KLHL11  
Affinity Capture-MS Homo sapiens
111 ERCC3  
Affinity Capture-MS Homo sapiens
112 MBNL1 4154
Affinity Capture-MS Homo sapiens
113 KIR3DS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 CALML5 51806
Affinity Capture-MS Homo sapiens
115 TEFM  
Affinity Capture-MS Homo sapiens
116 TSPAN6 7105
Affinity Capture-MS Homo sapiens
117 PINK1  
Affinity Capture-MS Homo sapiens
118 GOT1 2805
Affinity Capture-MS Homo sapiens
119 STK11 6794
Affinity Capture-MS Homo sapiens
120 ITGA9 3680
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 OR2A4 79541
Affinity Capture-MS Homo sapiens
122 GABPA 2551
Affinity Capture-MS Homo sapiens
123 PHF8  
Affinity Capture-MS Homo sapiens
124 GUCY1A3  
Affinity Capture-MS Homo sapiens
125 P2RX6  
Affinity Capture-MS Homo sapiens
126 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here