Gene description for IVL
Gene name involucrin
Gene symbol IVL
Other names/aliases -
Species Homo sapiens
 Database cross references - IVL
ExoCarta ExoCarta_3713
Entrez Gene 3713
HGNC 6187
MIM 147360
UniProt P07476  
 IVL identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Saliva 19199708    
 Gene ontology annotations for IVL
Molecular Function
    structural molecule activity GO:0005198 IDA
    protein binding, bridging GO:0030674 IDA
Biological Process
    response to UV-B GO:0010224 IDA
    keratinization GO:0031424 IEA
    peptide cross-linking GO:0018149 IDA
    isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine GO:0018153 TAS
    keratinocyte differentiation GO:0030216 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cornified envelope GO:0001533 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified IVL in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for IVL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LOR  
Reconstituted Complex Homo sapiens
2 IVL 3713
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 KRT1 3848
Reconstituted Complex Homo sapiens
4 CSTA 1475
Reconstituted Complex Homo sapiens
5 DSP 1832
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IVL is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here