Gene description for RHBDD1
Gene name rhomboid domain containing 1
Gene symbol RHBDD1
Other names/aliases RRP4
Species Homo sapiens
 Database cross references - RHBDD1
ExoCarta ExoCarta_84236
Vesiclepedia VP_84236
Entrez Gene 84236
HGNC 23081
UniProt Q8TEB9  
 RHBDD1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RHBDD1
Molecular Function
    endopeptidase activity GO:0004175 IDA
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IDA
    protein binding GO:0005515 IPI
Biological Process
    apoptotic process GO:0006915 IEA
    positive regulation of protein processing GO:0010954 ISS
    membrane protein intracellular domain proteolysis GO:0031293 ISS
    membrane protein proteolysis GO:0033619 IDA
    cellular response to unfolded protein GO:0034620 IBA
    cellular response to unfolded protein GO:0034620 IEP
    cellular response to unfolded protein GO:0034620 ISS
    cellular response to UV GO:0034644 ISS
    ERAD pathway GO:0036503 ISS
    negative regulation of apoptotic process GO:0043066 IBA
    negative regulation of apoptotic process GO:0043066 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of apoptotic process GO:0043066 ISS
    post-translational protein modification GO:0043687 ISS
    positive regulation of protein catabolic process GO:0045732 IDA
    positive regulation of protein catabolic process GO:0045732 IMP
    spermatid differentiation GO:0048515 ISS
    positive regulation of secretion GO:0051047 IMP
    membrane protein proteolysis involved in retrograde protein transport, ER to cytosol GO:1904211 ISS
    regulation of male germ cell proliferation GO:2000254 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 ISS
    mitochondrial membrane GO:0031966 IEA
    endoplasmic reticulum quality control compartment GO:0044322 ISS
 Experiment description of studies that identified RHBDD1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for RHBDD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 SEC22B 9554
Two-hybrid Homo sapiens
3 A1BG 1
Affinity Capture-MS Homo sapiens
4 IGHG3 3502
Affinity Capture-MS Homo sapiens
5 IGLC2 3538
Affinity Capture-MS Homo sapiens
6 SERPINB4 6318
Affinity Capture-MS Homo sapiens
7 CEACAM8 1088
Affinity Capture-MS Homo sapiens
8 CHRNA4  
Affinity Capture-MS Homo sapiens
9 RXFP1  
Affinity Capture-MS Homo sapiens
10 AZU1 566
Affinity Capture-MS Homo sapiens
11 OR10H2  
Affinity Capture-MS Homo sapiens
12 PQLC1  
Two-hybrid Homo sapiens
13 IVL 3713
Affinity Capture-MS Homo sapiens
14 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
15 NRSN1  
Affinity Capture-MS Homo sapiens
16 ABCB5  
Affinity Capture-MS Homo sapiens
17 TPTE2  
Affinity Capture-MS Homo sapiens
18 MYO1F 4542
Affinity Capture-MS Homo sapiens
19 GC 2638
Affinity Capture-MS Homo sapiens
20 FBXO25  
Biochemical Activity Homo sapiens
21 HK3  
Affinity Capture-MS Homo sapiens
22 ARSE 415
Affinity Capture-MS Homo sapiens
23 IGHM 3507
Affinity Capture-MS Homo sapiens
24 BSCL2  
Affinity Capture-MS Homo sapiens
25 OR6M1  
Affinity Capture-MS Homo sapiens
26 ITIH2 3698
Affinity Capture-MS Homo sapiens
27 AHSG 197
Affinity Capture-MS Homo sapiens
28 PLG 5340
Affinity Capture-MS Homo sapiens
29 NCF1  
Affinity Capture-MS Homo sapiens
30 S100P 6286
Affinity Capture-MS Homo sapiens
31 KDELR1 10945
Affinity Capture-MS Homo sapiens
32 HPX 3263
Affinity Capture-MS Homo sapiens
33 GABRG2  
Affinity Capture-MS Homo sapiens
34 PIGN 23556
Affinity Capture-MS Homo sapiens
35 ITIH1 3697
Affinity Capture-MS Homo sapiens
36 GSDMA 284110
Affinity Capture-MS Homo sapiens
37 RNF5  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
38 CTLA4  
Affinity Capture-MS Homo sapiens
39 ORM1 5004
Affinity Capture-MS Homo sapiens
40 C3 718
Affinity Capture-MS Homo sapiens
41 FAM8A1 51439
Affinity Capture-MS Homo sapiens
42 ACPP 55
Affinity Capture-MS Homo sapiens
43 S100A9 6280
Affinity Capture-MS Homo sapiens
44 YIPF3 25844
Affinity Capture-MS Homo sapiens
45 TMED9 54732
Affinity Capture-MS Homo sapiens
46 C1QC 714
Affinity Capture-MS Homo sapiens
47 BTNL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CHI3L1 1116
Affinity Capture-MS Homo sapiens
49 CPA4 51200
Affinity Capture-MS Homo sapiens
50 CCDC47 57003
Affinity Capture-MS Homo sapiens
51 SERPINA1 5265
Affinity Capture-MS Homo sapiens
52 PRTN3 5657
Affinity Capture-MS Homo sapiens
53 TMEM63C  
Affinity Capture-MS Homo sapiens
54 TMEM136  
Affinity Capture-MS Homo sapiens
55 ITGAM 3684
Affinity Capture-MS Homo sapiens
56 GCA 25801
Affinity Capture-MS Homo sapiens
57 RNF185  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CBR1 873
Affinity Capture-MS Homo sapiens
59 VTN 7448
Affinity Capture-MS Homo sapiens
60 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MANSC1 54682
Affinity Capture-MS Homo sapiens
62 POF1B 79983
Affinity Capture-MS Homo sapiens
63 HRG 3273
Affinity Capture-MS Homo sapiens
64 OR5H1  
Affinity Capture-MS Homo sapiens
65 PLBD1 79887
Affinity Capture-MS Homo sapiens
66 IGHA2 3494
Affinity Capture-MS Homo sapiens
67 FGA 2243
Affinity Capture-MS Homo sapiens
68 STOM 2040
Affinity Capture-MS Homo sapiens
69 OR4N2  
Affinity Capture-MS Homo sapiens
70 A2M 2
Affinity Capture-MS Homo sapiens
71 ORM2  
Affinity Capture-MS Homo sapiens
72 PLEKHB2 55041
Two-hybrid Homo sapiens
73 OR2W3  
Affinity Capture-MS Homo sapiens
74 CTSG 1511
Affinity Capture-MS Homo sapiens
75 FGG 2266
Affinity Capture-MS Homo sapiens
76 VCP 7415
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
77 KCNA6  
Affinity Capture-MS Homo sapiens
78 S100A8 6279
Affinity Capture-MS Homo sapiens
79 TTR 7276
Affinity Capture-MS Homo sapiens
80 TACSTD2 4070
Affinity Capture-MS Homo sapiens
81 ELANE 1991
Affinity Capture-MS Homo sapiens
82 ALB 213
Affinity Capture-MS Homo sapiens
83 SERPINB7 8710
Affinity Capture-MS Homo sapiens
84 ITGB2 3689
Affinity Capture-MS Homo sapiens
85 SERPINA3 12
Affinity Capture-MS Homo sapiens
86 GYPC 2995
Two-hybrid Homo sapiens
87 IGKC 3514
Affinity Capture-MS Homo sapiens
88 COX4I1 1327
Affinity Capture-MS Homo sapiens
89 CALML3 810
Affinity Capture-MS Homo sapiens
90 C9 735
Affinity Capture-MS Homo sapiens
91 FAM189B  
Affinity Capture-MS Homo sapiens
92 MPO 4353
Affinity Capture-MS Homo sapiens
93 SERPINB3 6317
Affinity Capture-MS Homo sapiens
94 MMP8  
Affinity Capture-MS Homo sapiens
95 TYMP 1890
Affinity Capture-MS Homo sapiens
96 TMIE  
Two-hybrid Homo sapiens
97 SERPIND1 3053
Affinity Capture-MS Homo sapiens
98 APOB 338
Affinity Capture-MS Homo sapiens
99 CARTPT  
Affinity Capture-MS Homo sapiens
100 S100A7 6278
Affinity Capture-MS Homo sapiens
101 CP 1356
Affinity Capture-MS Homo sapiens
102 TMEM42  
Two-hybrid Homo sapiens
103 S100A7A 338324
Affinity Capture-MS Homo sapiens
104 PI4K2A 55361
Affinity Capture-MS Homo sapiens
105 CREB3L1  
Two-hybrid Homo sapiens
106 FN1 2335
Affinity Capture-MS Homo sapiens
107 APCS 325
Affinity Capture-MS Homo sapiens
108 FUT3 2525
Affinity Capture-MS Homo sapiens
109 NOX1  
Affinity Capture-MS Homo sapiens
110 TMEM86B  
Two-hybrid Homo sapiens
111 CHRNB4  
Affinity Capture-MS Homo sapiens
112 PCDH10 57575
Affinity Capture-MS Homo sapiens
113 CMTM5  
Two-hybrid Homo sapiens
114 IGHG4 3503
Affinity Capture-MS Homo sapiens
115 LGALS7B 653499
Affinity Capture-MS Homo sapiens
116 KNG1 3827
Affinity Capture-MS Homo sapiens
117 IGHG1 3500
Affinity Capture-MS Homo sapiens
118 C8G 733
Affinity Capture-MS Homo sapiens
119 MMP9 4318
Affinity Capture-MS Homo sapiens
120 SERPING1 710
Affinity Capture-MS Homo sapiens
121 SLC17A8  
Affinity Capture-MS Homo sapiens
122 ITIH4 3700
Affinity Capture-MS Homo sapiens
123 KCNA5  
Affinity Capture-MS Homo sapiens
124 LCN2 3934
Affinity Capture-MS Homo sapiens
125 PEF1 553115
Affinity Capture-MS Homo sapiens
126 KCNA2  
Affinity Capture-MS Homo sapiens
127 A2ML1 144568
Affinity Capture-MS Homo sapiens
128 LDLRAD1  
Affinity Capture-MS Homo sapiens
129 MNDA 4332
Affinity Capture-MS Homo sapiens
130 IGLL5 100423062
Affinity Capture-MS Homo sapiens
131 CFH 3075
Affinity Capture-MS Homo sapiens
132 KCNC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 EDEM1  
Affinity Capture-MS Homo sapiens
134 FGB 2244
Affinity Capture-MS Homo sapiens
135 NSDHL 50814
Two-hybrid Homo sapiens
136 IGHG2 3501
Affinity Capture-MS Homo sapiens
137 OR2G6  
Affinity Capture-MS Homo sapiens
138 OLFM4 10562
Affinity Capture-MS Homo sapiens
139 TF 7018
Affinity Capture-MS Homo sapiens
140 TGM3 7053
Affinity Capture-MS Homo sapiens
141 CALML5 51806
Affinity Capture-MS Homo sapiens
142 GM2A 2760
Affinity Capture-MS Homo sapiens
143 TGM1 7051
Affinity Capture-MS Homo sapiens
144 BPI 671
Affinity Capture-MS Homo sapiens
145 PLA2G4D  
Affinity Capture-MS Homo sapiens
146 TMC4  
Affinity Capture-MS Homo sapiens
147 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 MARCH4  
Affinity Capture-MS Homo sapiens
149 TMEM31  
Affinity Capture-MS Homo sapiens
150 LTF 4057
Affinity Capture-MS Homo sapiens
151 VIM 7431
Affinity Capture-MS Homo sapiens
152 CHRNB1  
Affinity Capture-MS Homo sapiens
153 LCP1 3936
Affinity Capture-MS Homo sapiens
154 B3GNT8  
Affinity Capture-MS Homo sapiens
155 MCOLN2  
Affinity Capture-MS Homo sapiens
156 CTSH 1512
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RHBDD1 is involved
No pathways found





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