Gene description for RHBDD1
Gene name rhomboid domain containing 1
Gene symbol RHBDD1
Other names/aliases RRP4
Species Homo sapiens
 Database cross references - RHBDD1
ExoCarta ExoCarta_84236
Entrez Gene 84236
HGNC 23081
UniProt Q8TEB9  
 RHBDD1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RHBDD1
Molecular Function
    protein binding GO:0005515 IPI
    endopeptidase activity GO:0004175 IDA
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    regulation of male germ cell proliferation GO:2000254 ISS
    membrane protein proteolysis GO:0033619 IDA
    positive regulation of protein catabolic process GO:0045732 IMP
    apoptotic process GO:0006915 IEA
    cellular response to UV GO:0034644 ISS
    negative regulation of apoptotic process GO:0043066 ISS
    cellular response to unfolded protein GO:0034620 ISS
    positive regulation of secretion GO:0051047 IMP
    membrane protein intracellular domain proteolysis GO:0031293 ISS
    spermatid differentiation GO:0048515 ISS
    positive regulation of protein processing GO:0010954 ISS
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 ISS
    post-translational protein modification GO:0043687 ISS
Subcellular Localization
    endoplasmic reticulum quality control compartment GO:0044322 ISS
    mitochondrion GO:0005739 IEA
    integral component of endoplasmic reticulum membrane GO:0030176 ISS
    endoplasmic reticulum membrane GO:0005789 ISS
 Experiment description of studies that identified RHBDD1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for RHBDD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RHBDD1 is involved
No pathways found





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