Gene description for ELANE
Gene name	elastase, neutrophil expressed
Gene symbol	ELANE
Other names/aliases	ELA2 GE HLE HNE NE PMN-E SCN1
Species	Homo sapiens
Database cross references - ELANE
ExoCarta	ExoCarta_1991
Entrez Gene	1991
HGNC	3309
MIM	130130
UniProt	P08246
ELANE identified in exosomes derived from the following tissue/cell type
Thymus	23844026
Urine	19056867

Gene ontology annotations for ELANE

Molecular Function     endopeptidase activity GO:0004175 IDA     protein binding GO:0005515 IPI     peptidase activity GO:0008233 IDA     heparin binding GO:0008201 IDA     cytokine binding GO:0019955 IPI     RNA polymerase II transcription corepressor activity GO:0001106 IMP     serine-type endopeptidase activity GO:0004252 IEA     protease binding GO:0002020 IPI Biological Process     response to yeast GO:0001878 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     negative regulation of chemokine biosynthetic process GO:0045079 IDA     proteolysis GO:0006508 IDA     negative regulation of growth of symbiont in host GO:0044130 IEA     negative regulation of interleukin-8 biosynthetic process GO:0045415 IDA     negative regulation of chemotaxis GO:0050922 NAS     positive regulation of MAP kinase activity GO:0043406 NAS     defense response to bacterium GO:0042742 IDA     positive regulation of interleukin-8 biosynthetic process GO:0045416 IDA     negative regulation of inflammatory response GO:0050728 NAS     neutrophil mediated killing of fungus GO:0070947 IEA     phagocytosis GO:0006909 IEA     response to lipopolysaccharide GO:0032496 IEA     cellular calcium ion homeostasis GO:0006874 NAS     positive regulation of smooth muscle cell proliferation GO:0048661 IDA     extracellular matrix disassembly GO:0022617 TAS     protein catabolic process GO:0030163 NAS     positive regulation of immune response GO:0050778 IEA     collagen catabolic process GO:0030574 TAS     extracellular matrix organization GO:0030198 TAS     leukocyte migration GO:0050900 IEA     acute inflammatory response to antigenic stimulus GO:0002438 IEA     response to UV GO:0009411 IDA Subcellular Localization     cytoplasm GO:0005737 IDA     secretory granule GO:0030141 IDA     extracellular region GO:0005576 TAS     extracellular exosome GO:0070062 IDA     transcriptional repressor complex GO:0017053 IDA     cell surface GO:0009986 IDA